Cargando…

Correlation of Different MRI Scoring Systems with Long-Term Cognitive Outcome in Cooled Asphyxiated Newborns

(1) Background: Cerebral MRI plays a significant role in assessing the extent of brain injury in neonates with neonatal encephalopathy after perinatal asphyxia. Over the last decades, several MRI scoring systems were developed to enhance the predictive accuracy of MRI. The aim of this study was to v...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Ok-Hap, Jahn, Peter, Eichhorn, Joachim G., Dresbach, Till, Müller, Andreas, Sabir, Hemmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453158/
https://www.ncbi.nlm.nih.gov/pubmed/37628294
http://dx.doi.org/10.3390/children10081295
_version_ 1785095862839410688
author Kang, Ok-Hap
Jahn, Peter
Eichhorn, Joachim G.
Dresbach, Till
Müller, Andreas
Sabir, Hemmen
author_facet Kang, Ok-Hap
Jahn, Peter
Eichhorn, Joachim G.
Dresbach, Till
Müller, Andreas
Sabir, Hemmen
author_sort Kang, Ok-Hap
collection PubMed
description (1) Background: Cerebral MRI plays a significant role in assessing the extent of brain injury in neonates with neonatal encephalopathy after perinatal asphyxia. Over the last decades, several MRI scoring systems were developed to enhance the predictive accuracy of MRI. The aim of this study was to validate the correlation of four established MRI scoring systems with cognitive long-term outcomes in cooled asphyxiated newborns. (2) Methods: Forty neonates with neonatal encephalopathy treated with therapeutic hypothermia were included in this retrospective study. The MRI scans from the second week of life were scored using four existing MRI scoring systems (Barkovich, NICHD, Rutherford, and Weeke). The patients’ outcome was assessed with the Bayley Scales of Infant Development (BSID-III) at the age of 2 years. To evaluate the correlation between the MRI scoring system with the cognitive scores of BSID-III, the correlation coefficient was calculated for each scoring system. (3) Results: All four MRI scoring systems showed a significant correlation with the cognitive scores of BSID-III. The strongest correlation was found between the Weeke Score (r(2) = 0.43), followed by the Rutherford score (r(2) = 0.39), the NICHD score (r(2) = 0.22), and the Barkovich score (r(2) = 0.17). (4) Conclusion: Our study confirms previously published results in an independent cohort and indicates that the Weeke and Rutherford scores have the strongest correlation with the cognitive score of BSID-III in cooled asphyxiated newborns.
format Online
Article
Text
id pubmed-10453158
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104531582023-08-26 Correlation of Different MRI Scoring Systems with Long-Term Cognitive Outcome in Cooled Asphyxiated Newborns Kang, Ok-Hap Jahn, Peter Eichhorn, Joachim G. Dresbach, Till Müller, Andreas Sabir, Hemmen Children (Basel) Article (1) Background: Cerebral MRI plays a significant role in assessing the extent of brain injury in neonates with neonatal encephalopathy after perinatal asphyxia. Over the last decades, several MRI scoring systems were developed to enhance the predictive accuracy of MRI. The aim of this study was to validate the correlation of four established MRI scoring systems with cognitive long-term outcomes in cooled asphyxiated newborns. (2) Methods: Forty neonates with neonatal encephalopathy treated with therapeutic hypothermia were included in this retrospective study. The MRI scans from the second week of life were scored using four existing MRI scoring systems (Barkovich, NICHD, Rutherford, and Weeke). The patients’ outcome was assessed with the Bayley Scales of Infant Development (BSID-III) at the age of 2 years. To evaluate the correlation between the MRI scoring system with the cognitive scores of BSID-III, the correlation coefficient was calculated for each scoring system. (3) Results: All four MRI scoring systems showed a significant correlation with the cognitive scores of BSID-III. The strongest correlation was found between the Weeke Score (r(2) = 0.43), followed by the Rutherford score (r(2) = 0.39), the NICHD score (r(2) = 0.22), and the Barkovich score (r(2) = 0.17). (4) Conclusion: Our study confirms previously published results in an independent cohort and indicates that the Weeke and Rutherford scores have the strongest correlation with the cognitive score of BSID-III in cooled asphyxiated newborns. MDPI 2023-07-27 /pmc/articles/PMC10453158/ /pubmed/37628294 http://dx.doi.org/10.3390/children10081295 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Ok-Hap
Jahn, Peter
Eichhorn, Joachim G.
Dresbach, Till
Müller, Andreas
Sabir, Hemmen
Correlation of Different MRI Scoring Systems with Long-Term Cognitive Outcome in Cooled Asphyxiated Newborns
title Correlation of Different MRI Scoring Systems with Long-Term Cognitive Outcome in Cooled Asphyxiated Newborns
title_full Correlation of Different MRI Scoring Systems with Long-Term Cognitive Outcome in Cooled Asphyxiated Newborns
title_fullStr Correlation of Different MRI Scoring Systems with Long-Term Cognitive Outcome in Cooled Asphyxiated Newborns
title_full_unstemmed Correlation of Different MRI Scoring Systems with Long-Term Cognitive Outcome in Cooled Asphyxiated Newborns
title_short Correlation of Different MRI Scoring Systems with Long-Term Cognitive Outcome in Cooled Asphyxiated Newborns
title_sort correlation of different mri scoring systems with long-term cognitive outcome in cooled asphyxiated newborns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453158/
https://www.ncbi.nlm.nih.gov/pubmed/37628294
http://dx.doi.org/10.3390/children10081295
work_keys_str_mv AT kangokhap correlationofdifferentmriscoringsystemswithlongtermcognitiveoutcomeincooledasphyxiatednewborns
AT jahnpeter correlationofdifferentmriscoringsystemswithlongtermcognitiveoutcomeincooledasphyxiatednewborns
AT eichhornjoachimg correlationofdifferentmriscoringsystemswithlongtermcognitiveoutcomeincooledasphyxiatednewborns
AT dresbachtill correlationofdifferentmriscoringsystemswithlongtermcognitiveoutcomeincooledasphyxiatednewborns
AT mullerandreas correlationofdifferentmriscoringsystemswithlongtermcognitiveoutcomeincooledasphyxiatednewborns
AT sabirhemmen correlationofdifferentmriscoringsystemswithlongtermcognitiveoutcomeincooledasphyxiatednewborns