Conventional DNA-Damaging Cancer Therapies and Emerging cGAS-STING Activation: A Review and Perspectives Regarding Immunotherapeutic Potential

SIMPLE SUMMARY: The cGAS-STING cellular signaling pathway is a key member of the DNA damage response, whose role is to repair the DNA damage that occurs naturally during the life of a cell. Interestingly, cGAS-STING is known to promote immune responses against tumors, and is being explored for its p...

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Detalles Bibliográficos
Autores principales: Lewicky, Jordan D., Martel, Alexandrine L., Gupta, Mukul Raj, Roy, René, Rodriguez, Galaxia M., Vanderhyden, Barbara C., Le, Hoang-Thanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453198/
https://www.ncbi.nlm.nih.gov/pubmed/37627155
http://dx.doi.org/10.3390/cancers15164127

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