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Radio-Guided Lung Surgery: A Feasible Approach for a Cancer Precision Medicine

Background: Radio-guided surgery is a reliable approach used for localizing ground-glass opacities, lung nodules, and metastatic lymph nodes. Lung nodules, lymph node metastatic involvement, and ground-glass opacities often represent a challenge for surgical management and clinical work-up. Methods:...

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Autores principales: Conte, Miriam, De Feo, Maria Silvia, Frantellizzi, Viviana, Tomaciello, Miriam, Marampon, Francesco, Evangelista, Laura, Filippi, Luca, De Vincentis, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453216/
https://www.ncbi.nlm.nih.gov/pubmed/37627887
http://dx.doi.org/10.3390/diagnostics13162628
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author Conte, Miriam
De Feo, Maria Silvia
Frantellizzi, Viviana
Tomaciello, Miriam
Marampon, Francesco
Evangelista, Laura
Filippi, Luca
De Vincentis, Giuseppe
author_facet Conte, Miriam
De Feo, Maria Silvia
Frantellizzi, Viviana
Tomaciello, Miriam
Marampon, Francesco
Evangelista, Laura
Filippi, Luca
De Vincentis, Giuseppe
author_sort Conte, Miriam
collection PubMed
description Background: Radio-guided surgery is a reliable approach used for localizing ground-glass opacities, lung nodules, and metastatic lymph nodes. Lung nodules, lymph node metastatic involvement, and ground-glass opacities often represent a challenge for surgical management and clinical work-up. Methods: PubMed research was conducted from January 1997 to June 2023 using the keywords “radioguided surgery and lung cancer”. Results: Different studies were conducted with different tracers: technetium-99m-albumin macroaggregates, cyanoacrylate combined to technetium-99m-sulfur colloid, indium-111-pentetreotide, and fluorine-18-deoxyglucose. A study proposed naphthalocyanine radio-labeled with copper-64. Radio-guided surgery has been demonstrated to be a reliable approach in localizing a lesion, and has a low radiological burden for personnel exposure and low morbidity. The lack of necessity to conduct radio-guided surgery under fluoroscopy or echography makes this radio-guided surgery an easy way of performing precise surgical procedures. Conclusions: Radio-guided surgery is a feasible approach useful for the intraoperative localization of ground-glass opacities, lung nodules, and metastatic lymph nodes. It is a valid alternative to the existing approaches due to its low cost, associated low morbidity, the possibility to perform the procedure after several hours, the low radiation dose applied, and the small amount of time that is required to perform it.
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spelling pubmed-104532162023-08-26 Radio-Guided Lung Surgery: A Feasible Approach for a Cancer Precision Medicine Conte, Miriam De Feo, Maria Silvia Frantellizzi, Viviana Tomaciello, Miriam Marampon, Francesco Evangelista, Laura Filippi, Luca De Vincentis, Giuseppe Diagnostics (Basel) Review Background: Radio-guided surgery is a reliable approach used for localizing ground-glass opacities, lung nodules, and metastatic lymph nodes. Lung nodules, lymph node metastatic involvement, and ground-glass opacities often represent a challenge for surgical management and clinical work-up. Methods: PubMed research was conducted from January 1997 to June 2023 using the keywords “radioguided surgery and lung cancer”. Results: Different studies were conducted with different tracers: technetium-99m-albumin macroaggregates, cyanoacrylate combined to technetium-99m-sulfur colloid, indium-111-pentetreotide, and fluorine-18-deoxyglucose. A study proposed naphthalocyanine radio-labeled with copper-64. Radio-guided surgery has been demonstrated to be a reliable approach in localizing a lesion, and has a low radiological burden for personnel exposure and low morbidity. The lack of necessity to conduct radio-guided surgery under fluoroscopy or echography makes this radio-guided surgery an easy way of performing precise surgical procedures. Conclusions: Radio-guided surgery is a feasible approach useful for the intraoperative localization of ground-glass opacities, lung nodules, and metastatic lymph nodes. It is a valid alternative to the existing approaches due to its low cost, associated low morbidity, the possibility to perform the procedure after several hours, the low radiation dose applied, and the small amount of time that is required to perform it. MDPI 2023-08-09 /pmc/articles/PMC10453216/ /pubmed/37627887 http://dx.doi.org/10.3390/diagnostics13162628 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Conte, Miriam
De Feo, Maria Silvia
Frantellizzi, Viviana
Tomaciello, Miriam
Marampon, Francesco
Evangelista, Laura
Filippi, Luca
De Vincentis, Giuseppe
Radio-Guided Lung Surgery: A Feasible Approach for a Cancer Precision Medicine
title Radio-Guided Lung Surgery: A Feasible Approach for a Cancer Precision Medicine
title_full Radio-Guided Lung Surgery: A Feasible Approach for a Cancer Precision Medicine
title_fullStr Radio-Guided Lung Surgery: A Feasible Approach for a Cancer Precision Medicine
title_full_unstemmed Radio-Guided Lung Surgery: A Feasible Approach for a Cancer Precision Medicine
title_short Radio-Guided Lung Surgery: A Feasible Approach for a Cancer Precision Medicine
title_sort radio-guided lung surgery: a feasible approach for a cancer precision medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453216/
https://www.ncbi.nlm.nih.gov/pubmed/37627887
http://dx.doi.org/10.3390/diagnostics13162628
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