Reduction of Ca(2+) Entry by a Specific Block of KCa3.1 Channels Optimizes Cytotoxic Activity of NK Cells against T-ALL Jurkat Cells

Degranulation mediated killing mechanism by NK cells is dependent on store-operated Ca(2+) entry (SOCE) and has optimum at moderate intracellular Ca(2+) elevations so that partial block of SOCE optimizes the killing process. In this study, we tested the effect of the selective blocker of KCa3.1 chan...

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Detalles Bibliográficos
Autores principales: Olivas-Aguirre, Miguel, Cruz-Aguilar, Laura Hadit, Pottosin, Igor, Dobrovinskaya, Oxana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453324/
https://www.ncbi.nlm.nih.gov/pubmed/37626875
http://dx.doi.org/10.3390/cells12162065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453324/
https://www.ncbi.nlm.nih.gov/pubmed/37626875
http://dx.doi.org/10.3390/cells12162065

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