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Probiotics and Fecal Transplant: An Intervention in Delaying Chronic Kidney Disease Progression?

Chronic kidney disease (CKD) is a global health challenge affecting nearly 700 million people worldwide. In the United States alone, the Medicare costs for CKD management has reached nearly USD 80 billion per year. While reversing CKD may be possible in the future, current strategies aim to slow its...

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Autores principales: Sanekommu, Harshavardhan, Taj, Sobaan, Mah Noor, Rida, Umair Akmal, Muhammad, Akhtar, Reza, Hossain, Mohammad, Asif, Arif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453439/
https://www.ncbi.nlm.nih.gov/pubmed/37623261
http://dx.doi.org/10.3390/clinpract13040080
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author Sanekommu, Harshavardhan
Taj, Sobaan
Mah Noor, Rida
Umair Akmal, Muhammad
Akhtar, Reza
Hossain, Mohammad
Asif, Arif
author_facet Sanekommu, Harshavardhan
Taj, Sobaan
Mah Noor, Rida
Umair Akmal, Muhammad
Akhtar, Reza
Hossain, Mohammad
Asif, Arif
author_sort Sanekommu, Harshavardhan
collection PubMed
description Chronic kidney disease (CKD) is a global health challenge affecting nearly 700 million people worldwide. In the United States alone, the Medicare costs for CKD management has reached nearly USD 80 billion per year. While reversing CKD may be possible in the future, current strategies aim to slow its progression. For the most part, current management strategies have focused on employing Renin Angiotensin Aldosterone (RAS) inhibitors and optimizing blood pressure and diabetes mellitus control. Emerging data are showing that a disruption of the gut–kidney axis has a significant impact on delaying CKD progression. Recent investigations have documented promising results in using microbiota-based interventions to better manage CKD. This review will summarize the current evidence and explore future possibilities on the use of probiotics, prebiotics, synbiotics, and fecal microbial transplant to reduce CKD progression.
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spelling pubmed-104534392023-08-26 Probiotics and Fecal Transplant: An Intervention in Delaying Chronic Kidney Disease Progression? Sanekommu, Harshavardhan Taj, Sobaan Mah Noor, Rida Umair Akmal, Muhammad Akhtar, Reza Hossain, Mohammad Asif, Arif Clin Pract Opinion Chronic kidney disease (CKD) is a global health challenge affecting nearly 700 million people worldwide. In the United States alone, the Medicare costs for CKD management has reached nearly USD 80 billion per year. While reversing CKD may be possible in the future, current strategies aim to slow its progression. For the most part, current management strategies have focused on employing Renin Angiotensin Aldosterone (RAS) inhibitors and optimizing blood pressure and diabetes mellitus control. Emerging data are showing that a disruption of the gut–kidney axis has a significant impact on delaying CKD progression. Recent investigations have documented promising results in using microbiota-based interventions to better manage CKD. This review will summarize the current evidence and explore future possibilities on the use of probiotics, prebiotics, synbiotics, and fecal microbial transplant to reduce CKD progression. MDPI 2023-08-01 /pmc/articles/PMC10453439/ /pubmed/37623261 http://dx.doi.org/10.3390/clinpract13040080 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Sanekommu, Harshavardhan
Taj, Sobaan
Mah Noor, Rida
Umair Akmal, Muhammad
Akhtar, Reza
Hossain, Mohammad
Asif, Arif
Probiotics and Fecal Transplant: An Intervention in Delaying Chronic Kidney Disease Progression?
title Probiotics and Fecal Transplant: An Intervention in Delaying Chronic Kidney Disease Progression?
title_full Probiotics and Fecal Transplant: An Intervention in Delaying Chronic Kidney Disease Progression?
title_fullStr Probiotics and Fecal Transplant: An Intervention in Delaying Chronic Kidney Disease Progression?
title_full_unstemmed Probiotics and Fecal Transplant: An Intervention in Delaying Chronic Kidney Disease Progression?
title_short Probiotics and Fecal Transplant: An Intervention in Delaying Chronic Kidney Disease Progression?
title_sort probiotics and fecal transplant: an intervention in delaying chronic kidney disease progression?
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453439/
https://www.ncbi.nlm.nih.gov/pubmed/37623261
http://dx.doi.org/10.3390/clinpract13040080
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