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Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications

The growing impact of infections and the rapid emergence of antibiotic resistance represent a public health concern worldwide. The exponential development in the field of biomaterials and its multiple applications can offer a solution to the problems that derive from these situations. In this sense,...

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Autores principales: Ortega, Miguel A., De Leon-Oliva, Diego, Boaru, Diego Liviu, Fraile-Martinez, Oscar, García-Montero, Cielo, Diaz, Raul, Coca, Santiago, Barrena-Blázquez, Silvestra, Bujan, Julia, García-Honduvilla, Natalio, Saez, Miguel A., Álvarez-Mon, Melchor, Saz, Jose V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453485/
https://www.ncbi.nlm.nih.gov/pubmed/37623072
http://dx.doi.org/10.3390/gels9080617
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author Ortega, Miguel A.
De Leon-Oliva, Diego
Boaru, Diego Liviu
Fraile-Martinez, Oscar
García-Montero, Cielo
Diaz, Raul
Coca, Santiago
Barrena-Blázquez, Silvestra
Bujan, Julia
García-Honduvilla, Natalio
Saez, Miguel A.
Álvarez-Mon, Melchor
Saz, Jose V.
author_facet Ortega, Miguel A.
De Leon-Oliva, Diego
Boaru, Diego Liviu
Fraile-Martinez, Oscar
García-Montero, Cielo
Diaz, Raul
Coca, Santiago
Barrena-Blázquez, Silvestra
Bujan, Julia
García-Honduvilla, Natalio
Saez, Miguel A.
Álvarez-Mon, Melchor
Saz, Jose V.
author_sort Ortega, Miguel A.
collection PubMed
description The growing impact of infections and the rapid emergence of antibiotic resistance represent a public health concern worldwide. The exponential development in the field of biomaterials and its multiple applications can offer a solution to the problems that derive from these situations. In this sense, antimicrobial hydrogels represent a promising opportunity with multiple translational expectations in the medical management of infectious diseases due to their unique physicochemical and biological properties as well as for drug delivery in specific areas. Hydrogels are three-dimensional cross-linked networks of hydrophilic polymers that can absorb and retain large amounts of water or biological fluids. Moreover, antimicrobial hydrogels (AMH) present good biocompatibility, low toxicity, availability, viscoelasticity, biodegradability, and antimicrobial properties. In the present review, we collect and discuss the most promising strategies in the development of AMH, which are divided into hydrogels with inherent antimicrobial activity and antimicrobial agent-loaded hydrogels based on their composition. Then, we present an overview of the main translational applications: wound healing, tissue engineering and regeneration, drug delivery systems, contact lenses, 3D printing, biosensing, and water purification.
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spelling pubmed-104534852023-08-26 Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications Ortega, Miguel A. De Leon-Oliva, Diego Boaru, Diego Liviu Fraile-Martinez, Oscar García-Montero, Cielo Diaz, Raul Coca, Santiago Barrena-Blázquez, Silvestra Bujan, Julia García-Honduvilla, Natalio Saez, Miguel A. Álvarez-Mon, Melchor Saz, Jose V. Gels Review The growing impact of infections and the rapid emergence of antibiotic resistance represent a public health concern worldwide. The exponential development in the field of biomaterials and its multiple applications can offer a solution to the problems that derive from these situations. In this sense, antimicrobial hydrogels represent a promising opportunity with multiple translational expectations in the medical management of infectious diseases due to their unique physicochemical and biological properties as well as for drug delivery in specific areas. Hydrogels are three-dimensional cross-linked networks of hydrophilic polymers that can absorb and retain large amounts of water or biological fluids. Moreover, antimicrobial hydrogels (AMH) present good biocompatibility, low toxicity, availability, viscoelasticity, biodegradability, and antimicrobial properties. In the present review, we collect and discuss the most promising strategies in the development of AMH, which are divided into hydrogels with inherent antimicrobial activity and antimicrobial agent-loaded hydrogels based on their composition. Then, we present an overview of the main translational applications: wound healing, tissue engineering and regeneration, drug delivery systems, contact lenses, 3D printing, biosensing, and water purification. MDPI 2023-07-29 /pmc/articles/PMC10453485/ /pubmed/37623072 http://dx.doi.org/10.3390/gels9080617 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ortega, Miguel A.
De Leon-Oliva, Diego
Boaru, Diego Liviu
Fraile-Martinez, Oscar
García-Montero, Cielo
Diaz, Raul
Coca, Santiago
Barrena-Blázquez, Silvestra
Bujan, Julia
García-Honduvilla, Natalio
Saez, Miguel A.
Álvarez-Mon, Melchor
Saz, Jose V.
Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications
title Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications
title_full Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications
title_fullStr Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications
title_full_unstemmed Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications
title_short Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications
title_sort unraveling the new perspectives on antimicrobial hydrogels: state-of-the-art and translational applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453485/
https://www.ncbi.nlm.nih.gov/pubmed/37623072
http://dx.doi.org/10.3390/gels9080617
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