Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings

Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinica...

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Autores principales: Nguyen, Khoa D., Amerio, Andrea, Aguglia, Andrea, Magnani, Luca, Parise, Alberto, Conio, Benedetta, Serafini, Gianluca, Amore, Mario, Costanza, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453550/
https://www.ncbi.nlm.nih.gov/pubmed/37626909
http://dx.doi.org/10.3390/cells12162099
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author Nguyen, Khoa D.
Amerio, Andrea
Aguglia, Andrea
Magnani, Luca
Parise, Alberto
Conio, Benedetta
Serafini, Gianluca
Amore, Mario
Costanza, Alessandra
author_facet Nguyen, Khoa D.
Amerio, Andrea
Aguglia, Andrea
Magnani, Luca
Parise, Alberto
Conio, Benedetta
Serafini, Gianluca
Amore, Mario
Costanza, Alessandra
author_sort Nguyen, Khoa D.
collection PubMed
description Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates to immune system dysfunction in this psychiatric disorder. We conclude this review by attempting to develop a unifying hypothesis regarding the relative contributions of microglia and various immune cell populations to the development of schizophrenia. This may provide important translational insights that can become useful for addressing the multifaceted clinical presentation of schizophrenia.
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spelling pubmed-104535502023-08-26 Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings Nguyen, Khoa D. Amerio, Andrea Aguglia, Andrea Magnani, Luca Parise, Alberto Conio, Benedetta Serafini, Gianluca Amore, Mario Costanza, Alessandra Cells Review Schizophrenia is a complex psychiatric condition that may involve immune system dysregulation. Since most putative disease mechanisms in schizophrenia have been derived from genetic association studies and fluid-based molecular analyses, this review aims to summarize the emerging evidence on clinical correlates to immune system dysfunction in this psychiatric disorder. We conclude this review by attempting to develop a unifying hypothesis regarding the relative contributions of microglia and various immune cell populations to the development of schizophrenia. This may provide important translational insights that can become useful for addressing the multifaceted clinical presentation of schizophrenia. MDPI 2023-08-19 /pmc/articles/PMC10453550/ /pubmed/37626909 http://dx.doi.org/10.3390/cells12162099 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nguyen, Khoa D.
Amerio, Andrea
Aguglia, Andrea
Magnani, Luca
Parise, Alberto
Conio, Benedetta
Serafini, Gianluca
Amore, Mario
Costanza, Alessandra
Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings
title Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings
title_full Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings
title_fullStr Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings
title_full_unstemmed Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings
title_short Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings
title_sort microglia and other cellular mediators of immunological dysfunction in schizophrenia: a narrative synthesis of clinical findings
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453550/
https://www.ncbi.nlm.nih.gov/pubmed/37626909
http://dx.doi.org/10.3390/cells12162099
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