The Microtubule-Targeting Agent Pretubulysin Impairs the Inflammatory Response in Endothelial Cells by a JNK-Dependent Deregulation of the Histone Acetyltransferase Brd4

The anti-inflammatory effects of depolymerizing microtubule-targeting agents on leukocytes are known for a long time, but the potential involvement of the vascular endothelium and the underlying mechanistic basis is still largely unclear. Using the recently synthesized depolymerizing microtubule-tar...

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Detalles Bibliográficos
Autores principales: Primke, Tobias F., Ingelfinger, Rebecca, Elewa, Mohammed A. F., Macinkovic, Igor, Weigert, Andreas, Fabritius, Matthias P., Reichel, Christoph A., Ullrich, Angelika, Kazmaier, Uli, Burgers, Luisa D., Fürst, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453553/
https://www.ncbi.nlm.nih.gov/pubmed/37626922
http://dx.doi.org/10.3390/cells12162112

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