Cargando…
Xanthan-Gum/Pluronic-F-127-Based-Drug-Loaded Polymeric Hydrogels Synthesized by Free Radical Polymerization Technique for Management of Attention-Deficit/Hyperactivity Disorder
Smart and intelligent xanthan gum/pluronic F-127 hydrogels were fabricated for the controlled delivery of atomoxetine HCl. Different parameters such as DSC, TGA, FTIR, XRD, SEM, drug loading, porosity, swelling index, drug release, and kinetics modeling were appraised for the prepared matrices of hy...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453617/ https://www.ncbi.nlm.nih.gov/pubmed/37623095 http://dx.doi.org/10.3390/gels9080640 |
_version_ | 1785095981242515456 |
---|---|
author | Suhail, Muhammad Chiu, I-Hui Lai, Yi-Ru Khan, Arshad Al-Sowayan, Noorah Saleh Ullah, Hamid Wu, Pao-Chu |
author_facet | Suhail, Muhammad Chiu, I-Hui Lai, Yi-Ru Khan, Arshad Al-Sowayan, Noorah Saleh Ullah, Hamid Wu, Pao-Chu |
author_sort | Suhail, Muhammad |
collection | PubMed |
description | Smart and intelligent xanthan gum/pluronic F-127 hydrogels were fabricated for the controlled delivery of atomoxetine HCl. Different parameters such as DSC, TGA, FTIR, XRD, SEM, drug loading, porosity, swelling index, drug release, and kinetics modeling were appraised for the prepared matrices of hydrogels. FTIR confirmed the successful synthesis of the hydrogel, while TGA and DSC analysis indicated that the thermal stability of the reagents was improved after the polymerization technique. SEM revealed the hard surface of the hydrogel, while XRD indicated a reduction in crystallinity of the reagents. High gel fraction was achieved with high incorporated contents of the polymers and the monomer. An increase in porosity, drug loading, swelling, and drug release was observed with the increase in the concentrations of xanthan gum and acrylic acid, whereas Pluronic F-127 showed the opposite effect. A negligible swelling index was shown at pH 1.2 and 4.6 while greater swelling was observed at pH 7.4, indicating a pH-responsive nature of the designed hydrogels. Furthermore, a higher drug release was found at pH 7.4 compared to pH 1.2 and 4.6, respectively. The first kinetics order was followed by the prepared hydrogel formulations. Thus, it is signified from the discussion that smart xanthan gum/pluronic F-127 hydrogels have the potential to control the release of the atomoxetine HCl in the colon for an extended period of time. |
format | Online Article Text |
id | pubmed-10453617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104536172023-08-26 Xanthan-Gum/Pluronic-F-127-Based-Drug-Loaded Polymeric Hydrogels Synthesized by Free Radical Polymerization Technique for Management of Attention-Deficit/Hyperactivity Disorder Suhail, Muhammad Chiu, I-Hui Lai, Yi-Ru Khan, Arshad Al-Sowayan, Noorah Saleh Ullah, Hamid Wu, Pao-Chu Gels Article Smart and intelligent xanthan gum/pluronic F-127 hydrogels were fabricated for the controlled delivery of atomoxetine HCl. Different parameters such as DSC, TGA, FTIR, XRD, SEM, drug loading, porosity, swelling index, drug release, and kinetics modeling were appraised for the prepared matrices of hydrogels. FTIR confirmed the successful synthesis of the hydrogel, while TGA and DSC analysis indicated that the thermal stability of the reagents was improved after the polymerization technique. SEM revealed the hard surface of the hydrogel, while XRD indicated a reduction in crystallinity of the reagents. High gel fraction was achieved with high incorporated contents of the polymers and the monomer. An increase in porosity, drug loading, swelling, and drug release was observed with the increase in the concentrations of xanthan gum and acrylic acid, whereas Pluronic F-127 showed the opposite effect. A negligible swelling index was shown at pH 1.2 and 4.6 while greater swelling was observed at pH 7.4, indicating a pH-responsive nature of the designed hydrogels. Furthermore, a higher drug release was found at pH 7.4 compared to pH 1.2 and 4.6, respectively. The first kinetics order was followed by the prepared hydrogel formulations. Thus, it is signified from the discussion that smart xanthan gum/pluronic F-127 hydrogels have the potential to control the release of the atomoxetine HCl in the colon for an extended period of time. MDPI 2023-08-08 /pmc/articles/PMC10453617/ /pubmed/37623095 http://dx.doi.org/10.3390/gels9080640 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Suhail, Muhammad Chiu, I-Hui Lai, Yi-Ru Khan, Arshad Al-Sowayan, Noorah Saleh Ullah, Hamid Wu, Pao-Chu Xanthan-Gum/Pluronic-F-127-Based-Drug-Loaded Polymeric Hydrogels Synthesized by Free Radical Polymerization Technique for Management of Attention-Deficit/Hyperactivity Disorder |
title | Xanthan-Gum/Pluronic-F-127-Based-Drug-Loaded Polymeric Hydrogels Synthesized by Free Radical Polymerization Technique for Management of Attention-Deficit/Hyperactivity Disorder |
title_full | Xanthan-Gum/Pluronic-F-127-Based-Drug-Loaded Polymeric Hydrogels Synthesized by Free Radical Polymerization Technique for Management of Attention-Deficit/Hyperactivity Disorder |
title_fullStr | Xanthan-Gum/Pluronic-F-127-Based-Drug-Loaded Polymeric Hydrogels Synthesized by Free Radical Polymerization Technique for Management of Attention-Deficit/Hyperactivity Disorder |
title_full_unstemmed | Xanthan-Gum/Pluronic-F-127-Based-Drug-Loaded Polymeric Hydrogels Synthesized by Free Radical Polymerization Technique for Management of Attention-Deficit/Hyperactivity Disorder |
title_short | Xanthan-Gum/Pluronic-F-127-Based-Drug-Loaded Polymeric Hydrogels Synthesized by Free Radical Polymerization Technique for Management of Attention-Deficit/Hyperactivity Disorder |
title_sort | xanthan-gum/pluronic-f-127-based-drug-loaded polymeric hydrogels synthesized by free radical polymerization technique for management of attention-deficit/hyperactivity disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453617/ https://www.ncbi.nlm.nih.gov/pubmed/37623095 http://dx.doi.org/10.3390/gels9080640 |
work_keys_str_mv | AT suhailmuhammad xanthangumpluronicf127baseddrugloadedpolymerichydrogelssynthesizedbyfreeradicalpolymerizationtechniqueformanagementofattentiondeficithyperactivitydisorder AT chiuihui xanthangumpluronicf127baseddrugloadedpolymerichydrogelssynthesizedbyfreeradicalpolymerizationtechniqueformanagementofattentiondeficithyperactivitydisorder AT laiyiru xanthangumpluronicf127baseddrugloadedpolymerichydrogelssynthesizedbyfreeradicalpolymerizationtechniqueformanagementofattentiondeficithyperactivitydisorder AT khanarshad xanthangumpluronicf127baseddrugloadedpolymerichydrogelssynthesizedbyfreeradicalpolymerizationtechniqueformanagementofattentiondeficithyperactivitydisorder AT alsowayannoorahsaleh xanthangumpluronicf127baseddrugloadedpolymerichydrogelssynthesizedbyfreeradicalpolymerizationtechniqueformanagementofattentiondeficithyperactivitydisorder AT ullahhamid xanthangumpluronicf127baseddrugloadedpolymerichydrogelssynthesizedbyfreeradicalpolymerizationtechniqueformanagementofattentiondeficithyperactivitydisorder AT wupaochu xanthangumpluronicf127baseddrugloadedpolymerichydrogelssynthesizedbyfreeradicalpolymerizationtechniqueformanagementofattentiondeficithyperactivitydisorder |