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Ultra-High-Frequency Ultrasonography of Labial Glands in Pediatric Sjögren’s Disease: A Preliminary Study

Sjögren’s disease (SD) is a chronic autoimmune disease primarily affecting lacrimal and salivary glands. The diagnosis of pediatric SD mostly relies on clinical suspect, resulting in a significant diagnostic delay. Recently, ultrahigh-frequency ultrasound (UHFUS) of labial glands has been proposed a...

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Autores principales: Marrani, Edoardo, Fulvio, Giovanni, Virgili, Camilla, Izzetti, Rossana, Dini, Valentina, Oranges, Teresa, Baldini, Chiara, Simonini, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453647/
https://www.ncbi.nlm.nih.gov/pubmed/37627954
http://dx.doi.org/10.3390/diagnostics13162695
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author Marrani, Edoardo
Fulvio, Giovanni
Virgili, Camilla
Izzetti, Rossana
Dini, Valentina
Oranges, Teresa
Baldini, Chiara
Simonini, Gabriele
author_facet Marrani, Edoardo
Fulvio, Giovanni
Virgili, Camilla
Izzetti, Rossana
Dini, Valentina
Oranges, Teresa
Baldini, Chiara
Simonini, Gabriele
author_sort Marrani, Edoardo
collection PubMed
description Sjögren’s disease (SD) is a chronic autoimmune disease primarily affecting lacrimal and salivary glands. The diagnosis of pediatric SD mostly relies on clinical suspect, resulting in a significant diagnostic delay. Recently, ultrahigh-frequency ultrasound (UHFUS) of labial glands has been proposed as a diagnostic method in adults with suspected SD. Until now, there have been no studies about UHFUS in pediatric diagnostic work-up. The aim of the study was to evaluate the potential role of UHFUS of minor salivary glands in pediatric SD. Consecutive pediatric patients with a diagnosis of pediatric SD seen at AOU Meyer IRCSS were evaluated. Intraoral UHFUS scan of the lip mucosa was performed with Vevo MD equipment, using a 70 MHz probe with a standardized protocol and the images were independently reviewed by two operators. Lip salivary glands were assessed by using a four-grade semiquantitative scoring system for parenchymal alteration and vascularization. Twelve patients were included. When applying UHFUS to this cohort of patients, all patients showed a UHFUS grade of ≥1 with 8/12 showing a mild glandular alteration (i.e., grade 1), 2/12 a moderate glandular alteration (i.e., grade 2) and finally 2/12 a severe glandular alteration (i.e., grade 3). Moderate intraglandular vascularization was seen in 9/12, with only 3/12 showing mild intraglandular vascularization. Due to limited size of the sample, the relationship between histological findings, autoantibodies status and UHFUS grade could not be performed. This preliminary study seems to report UHFUS as feasibility technique to identify salivary gland alterations in children with a clinical suspect of SD.
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spelling pubmed-104536472023-08-26 Ultra-High-Frequency Ultrasonography of Labial Glands in Pediatric Sjögren’s Disease: A Preliminary Study Marrani, Edoardo Fulvio, Giovanni Virgili, Camilla Izzetti, Rossana Dini, Valentina Oranges, Teresa Baldini, Chiara Simonini, Gabriele Diagnostics (Basel) Article Sjögren’s disease (SD) is a chronic autoimmune disease primarily affecting lacrimal and salivary glands. The diagnosis of pediatric SD mostly relies on clinical suspect, resulting in a significant diagnostic delay. Recently, ultrahigh-frequency ultrasound (UHFUS) of labial glands has been proposed as a diagnostic method in adults with suspected SD. Until now, there have been no studies about UHFUS in pediatric diagnostic work-up. The aim of the study was to evaluate the potential role of UHFUS of minor salivary glands in pediatric SD. Consecutive pediatric patients with a diagnosis of pediatric SD seen at AOU Meyer IRCSS were evaluated. Intraoral UHFUS scan of the lip mucosa was performed with Vevo MD equipment, using a 70 MHz probe with a standardized protocol and the images were independently reviewed by two operators. Lip salivary glands were assessed by using a four-grade semiquantitative scoring system for parenchymal alteration and vascularization. Twelve patients were included. When applying UHFUS to this cohort of patients, all patients showed a UHFUS grade of ≥1 with 8/12 showing a mild glandular alteration (i.e., grade 1), 2/12 a moderate glandular alteration (i.e., grade 2) and finally 2/12 a severe glandular alteration (i.e., grade 3). Moderate intraglandular vascularization was seen in 9/12, with only 3/12 showing mild intraglandular vascularization. Due to limited size of the sample, the relationship between histological findings, autoantibodies status and UHFUS grade could not be performed. This preliminary study seems to report UHFUS as feasibility technique to identify salivary gland alterations in children with a clinical suspect of SD. MDPI 2023-08-16 /pmc/articles/PMC10453647/ /pubmed/37627954 http://dx.doi.org/10.3390/diagnostics13162695 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marrani, Edoardo
Fulvio, Giovanni
Virgili, Camilla
Izzetti, Rossana
Dini, Valentina
Oranges, Teresa
Baldini, Chiara
Simonini, Gabriele
Ultra-High-Frequency Ultrasonography of Labial Glands in Pediatric Sjögren’s Disease: A Preliminary Study
title Ultra-High-Frequency Ultrasonography of Labial Glands in Pediatric Sjögren’s Disease: A Preliminary Study
title_full Ultra-High-Frequency Ultrasonography of Labial Glands in Pediatric Sjögren’s Disease: A Preliminary Study
title_fullStr Ultra-High-Frequency Ultrasonography of Labial Glands in Pediatric Sjögren’s Disease: A Preliminary Study
title_full_unstemmed Ultra-High-Frequency Ultrasonography of Labial Glands in Pediatric Sjögren’s Disease: A Preliminary Study
title_short Ultra-High-Frequency Ultrasonography of Labial Glands in Pediatric Sjögren’s Disease: A Preliminary Study
title_sort ultra-high-frequency ultrasonography of labial glands in pediatric sjögren’s disease: a preliminary study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453647/
https://www.ncbi.nlm.nih.gov/pubmed/37627954
http://dx.doi.org/10.3390/diagnostics13162695
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