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Human Lung Organoids—A Novel Experimental and Precision Medicine Approach
The global burden of respiratory diseases is very high and still on the rise, prompting the need for accurate models for basic and translational research. Several model systems are currently available ranging from simple airway cell cultures to complex tissue-engineered lungs. In recent years, human...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453737/ https://www.ncbi.nlm.nih.gov/pubmed/37626876 http://dx.doi.org/10.3390/cells12162067 |
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author | Kühl, Laura Graichen, Pauline von Daacke, Nele Mende, Anne Wygrecka, Malgorzata Potaczek, Daniel P. Miethe, Sarah Garn, Holger |
author_facet | Kühl, Laura Graichen, Pauline von Daacke, Nele Mende, Anne Wygrecka, Malgorzata Potaczek, Daniel P. Miethe, Sarah Garn, Holger |
author_sort | Kühl, Laura |
collection | PubMed |
description | The global burden of respiratory diseases is very high and still on the rise, prompting the need for accurate models for basic and translational research. Several model systems are currently available ranging from simple airway cell cultures to complex tissue-engineered lungs. In recent years, human lung organoids have been established as highly transferrable three-dimensional in vitro model systems for lung research. For acute infectious and chronic inflammatory diseases as well as lung cancer, human lung organoids have opened possibilities for precise in vitro research and a deeper understanding of mechanisms underlying lung injury and regeneration. Human lung organoids from induced pluripotent stem cells or from adult stem cells of patients’ samples introduce tools for understanding developmental processes and personalized medicine approaches. When further state-of-the-art technologies and protocols come into use, the full potential of human lung organoids can be harnessed. High-throughput assays in drug development, gene therapy, and organoid transplantation are current applications of organoids in translational research. In this review, we emphasize novel approaches in translational and personalized medicine in lung research focusing on the use of human lung organoids. |
format | Online Article Text |
id | pubmed-10453737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104537372023-08-26 Human Lung Organoids—A Novel Experimental and Precision Medicine Approach Kühl, Laura Graichen, Pauline von Daacke, Nele Mende, Anne Wygrecka, Malgorzata Potaczek, Daniel P. Miethe, Sarah Garn, Holger Cells Review The global burden of respiratory diseases is very high and still on the rise, prompting the need for accurate models for basic and translational research. Several model systems are currently available ranging from simple airway cell cultures to complex tissue-engineered lungs. In recent years, human lung organoids have been established as highly transferrable three-dimensional in vitro model systems for lung research. For acute infectious and chronic inflammatory diseases as well as lung cancer, human lung organoids have opened possibilities for precise in vitro research and a deeper understanding of mechanisms underlying lung injury and regeneration. Human lung organoids from induced pluripotent stem cells or from adult stem cells of patients’ samples introduce tools for understanding developmental processes and personalized medicine approaches. When further state-of-the-art technologies and protocols come into use, the full potential of human lung organoids can be harnessed. High-throughput assays in drug development, gene therapy, and organoid transplantation are current applications of organoids in translational research. In this review, we emphasize novel approaches in translational and personalized medicine in lung research focusing on the use of human lung organoids. MDPI 2023-08-15 /pmc/articles/PMC10453737/ /pubmed/37626876 http://dx.doi.org/10.3390/cells12162067 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kühl, Laura Graichen, Pauline von Daacke, Nele Mende, Anne Wygrecka, Malgorzata Potaczek, Daniel P. Miethe, Sarah Garn, Holger Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
title | Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
title_full | Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
title_fullStr | Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
title_full_unstemmed | Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
title_short | Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
title_sort | human lung organoids—a novel experimental and precision medicine approach |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453737/ https://www.ncbi.nlm.nih.gov/pubmed/37626876 http://dx.doi.org/10.3390/cells12162067 |
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