Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and Degeneration

HK2 and PKM2 are two main regulators of aerobic glycolysis. Photoreceptors (PRs) use aerobic glycolysis to produce the biomass necessary for the daily renewal of their outer segments. Previous work has shown that HK2 and PKM2 are important for the normal function and long-term survival of PRs but ar...

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Detalles Bibliográficos
Autores principales: Weh, Eric, Goswami, Moloy, Chaudhury, Sraboni, Fernando, Roshini, Miller, Nick, Hager, Heather, Sheskey, Sarah, Sharma, Vikram, Wubben, Thomas J., Besirli, Cagri G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453858/
https://www.ncbi.nlm.nih.gov/pubmed/37626853
http://dx.doi.org/10.3390/cells12162043

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