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Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization
Ascorbic acid (AA) has many health benefits, including immune and cardiovascular deficiency protection, prenatal problems, and skin diseases. Unfortunately, AA is easily oxidized and has limited bioavailability. Thus, the development of formulations that stabilize and enhance the efficacy of AA is a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453865/ https://www.ncbi.nlm.nih.gov/pubmed/37623104 http://dx.doi.org/10.3390/gels9080649 |
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author | Loza-Rodríguez, Noèlia Millán-Sánchez, Aina López, Olga |
author_facet | Loza-Rodríguez, Noèlia Millán-Sánchez, Aina López, Olga |
author_sort | Loza-Rodríguez, Noèlia |
collection | PubMed |
description | Ascorbic acid (AA) has many health benefits, including immune and cardiovascular deficiency protection, prenatal problems, and skin diseases. Unfortunately, AA is easily oxidized and has limited bioavailability. Thus, the development of formulations that stabilize and enhance the efficacy of AA is a challenge. In this study, 4% AA was encapsulated in two recently developed gels, a hydrogel and a bigel. The hydrogel was formed exclusively with lipids and water, and the bigel was a combination of the hydrogel with an oleogel formed with olive oil and beeswax. The effect of AA in gel microstructures was determined using X-ray scattering, rheology, and texture analysis. Additionally, the capacity of these materials to protect AA from degradation upon temperature and sunlight was studied. Results showed that the incorporation of AA into both materials did not affect their microstructure. Moreover, hydrogel-protected AA showed only 2% degradation after three months at 8 °C, while in aqueous solution, it degraded by 12%. Regarding sunlight, bigel showed a good shielding effect, exhibiting only 2% AA degradation after 22 h of exposure, whereas in aqueous solution, AA degraded by 10%. These results suggest that both proposed gels could be used in biomedical applications and the field of food. |
format | Online Article Text |
id | pubmed-10453865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104538652023-08-26 Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization Loza-Rodríguez, Noèlia Millán-Sánchez, Aina López, Olga Gels Article Ascorbic acid (AA) has many health benefits, including immune and cardiovascular deficiency protection, prenatal problems, and skin diseases. Unfortunately, AA is easily oxidized and has limited bioavailability. Thus, the development of formulations that stabilize and enhance the efficacy of AA is a challenge. In this study, 4% AA was encapsulated in two recently developed gels, a hydrogel and a bigel. The hydrogel was formed exclusively with lipids and water, and the bigel was a combination of the hydrogel with an oleogel formed with olive oil and beeswax. The effect of AA in gel microstructures was determined using X-ray scattering, rheology, and texture analysis. Additionally, the capacity of these materials to protect AA from degradation upon temperature and sunlight was studied. Results showed that the incorporation of AA into both materials did not affect their microstructure. Moreover, hydrogel-protected AA showed only 2% degradation after three months at 8 °C, while in aqueous solution, it degraded by 12%. Regarding sunlight, bigel showed a good shielding effect, exhibiting only 2% AA degradation after 22 h of exposure, whereas in aqueous solution, AA degraded by 10%. These results suggest that both proposed gels could be used in biomedical applications and the field of food. MDPI 2023-08-11 /pmc/articles/PMC10453865/ /pubmed/37623104 http://dx.doi.org/10.3390/gels9080649 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Loza-Rodríguez, Noèlia Millán-Sánchez, Aina López, Olga Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization |
title | Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization |
title_full | Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization |
title_fullStr | Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization |
title_full_unstemmed | Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization |
title_short | Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization |
title_sort | characteristics of a lipid hydrogel and bigel as matrices for ascorbic acid stabilization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453865/ https://www.ncbi.nlm.nih.gov/pubmed/37623104 http://dx.doi.org/10.3390/gels9080649 |
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