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Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization

Ascorbic acid (AA) has many health benefits, including immune and cardiovascular deficiency protection, prenatal problems, and skin diseases. Unfortunately, AA is easily oxidized and has limited bioavailability. Thus, the development of formulations that stabilize and enhance the efficacy of AA is a...

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Autores principales: Loza-Rodríguez, Noèlia, Millán-Sánchez, Aina, López, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453865/
https://www.ncbi.nlm.nih.gov/pubmed/37623104
http://dx.doi.org/10.3390/gels9080649
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author Loza-Rodríguez, Noèlia
Millán-Sánchez, Aina
López, Olga
author_facet Loza-Rodríguez, Noèlia
Millán-Sánchez, Aina
López, Olga
author_sort Loza-Rodríguez, Noèlia
collection PubMed
description Ascorbic acid (AA) has many health benefits, including immune and cardiovascular deficiency protection, prenatal problems, and skin diseases. Unfortunately, AA is easily oxidized and has limited bioavailability. Thus, the development of formulations that stabilize and enhance the efficacy of AA is a challenge. In this study, 4% AA was encapsulated in two recently developed gels, a hydrogel and a bigel. The hydrogel was formed exclusively with lipids and water, and the bigel was a combination of the hydrogel with an oleogel formed with olive oil and beeswax. The effect of AA in gel microstructures was determined using X-ray scattering, rheology, and texture analysis. Additionally, the capacity of these materials to protect AA from degradation upon temperature and sunlight was studied. Results showed that the incorporation of AA into both materials did not affect their microstructure. Moreover, hydrogel-protected AA showed only 2% degradation after three months at 8 °C, while in aqueous solution, it degraded by 12%. Regarding sunlight, bigel showed a good shielding effect, exhibiting only 2% AA degradation after 22 h of exposure, whereas in aqueous solution, AA degraded by 10%. These results suggest that both proposed gels could be used in biomedical applications and the field of food.
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spelling pubmed-104538652023-08-26 Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization Loza-Rodríguez, Noèlia Millán-Sánchez, Aina López, Olga Gels Article Ascorbic acid (AA) has many health benefits, including immune and cardiovascular deficiency protection, prenatal problems, and skin diseases. Unfortunately, AA is easily oxidized and has limited bioavailability. Thus, the development of formulations that stabilize and enhance the efficacy of AA is a challenge. In this study, 4% AA was encapsulated in two recently developed gels, a hydrogel and a bigel. The hydrogel was formed exclusively with lipids and water, and the bigel was a combination of the hydrogel with an oleogel formed with olive oil and beeswax. The effect of AA in gel microstructures was determined using X-ray scattering, rheology, and texture analysis. Additionally, the capacity of these materials to protect AA from degradation upon temperature and sunlight was studied. Results showed that the incorporation of AA into both materials did not affect their microstructure. Moreover, hydrogel-protected AA showed only 2% degradation after three months at 8 °C, while in aqueous solution, it degraded by 12%. Regarding sunlight, bigel showed a good shielding effect, exhibiting only 2% AA degradation after 22 h of exposure, whereas in aqueous solution, AA degraded by 10%. These results suggest that both proposed gels could be used in biomedical applications and the field of food. MDPI 2023-08-11 /pmc/articles/PMC10453865/ /pubmed/37623104 http://dx.doi.org/10.3390/gels9080649 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Loza-Rodríguez, Noèlia
Millán-Sánchez, Aina
López, Olga
Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization
title Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization
title_full Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization
title_fullStr Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization
title_full_unstemmed Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization
title_short Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization
title_sort characteristics of a lipid hydrogel and bigel as matrices for ascorbic acid stabilization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453865/
https://www.ncbi.nlm.nih.gov/pubmed/37623104
http://dx.doi.org/10.3390/gels9080649
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