PSMA Targeted Molecular Imaging and Radioligand Therapy for Prostate Cancer: Optimal Patient and Treatment Issues

Theranostics (therapy + diagnosis) targeting prostate-specific membrane antigen (PSMA) is an emerging therapeutic modality that could alter treatment strategies for prostate cancer. Although PSMA-targeted radioligand therapy (PSMA-RLT) has a highly therapeutic effect on PSMA-positive tumor tissue, t...

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Autores principales: Hoshi, Seiji, Yaginuma, Kei, Meguro, Satoru, Onagi, Akifumi, Matsuoka, Kanako, Hata, Junya, Sato, Yuichi, Akaihata, Hidenori, Kataoka, Masao, Ogawa, Soichiro, Uemura, Motohide, Kojima, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453875/
https://www.ncbi.nlm.nih.gov/pubmed/37623010
http://dx.doi.org/10.3390/curroncol30080529
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author Hoshi, Seiji
Yaginuma, Kei
Meguro, Satoru
Onagi, Akifumi
Matsuoka, Kanako
Hata, Junya
Sato, Yuichi
Akaihata, Hidenori
Kataoka, Masao
Ogawa, Soichiro
Uemura, Motohide
Kojima, Yoshiyuki
author_facet Hoshi, Seiji
Yaginuma, Kei
Meguro, Satoru
Onagi, Akifumi
Matsuoka, Kanako
Hata, Junya
Sato, Yuichi
Akaihata, Hidenori
Kataoka, Masao
Ogawa, Soichiro
Uemura, Motohide
Kojima, Yoshiyuki
author_sort Hoshi, Seiji
collection PubMed
description Theranostics (therapy + diagnosis) targeting prostate-specific membrane antigen (PSMA) is an emerging therapeutic modality that could alter treatment strategies for prostate cancer. Although PSMA-targeted radioligand therapy (PSMA-RLT) has a highly therapeutic effect on PSMA-positive tumor tissue, the efficacy of PSMA-RLT depends on PSMA expression. Moreover, predictors of treatment response other than PSMA expression are under investigation. Therefore, the optimal patient population for PSMA-RLT remains unclear. This review provides an overview of the current status of theranostics for prostate cancer, focusing on PSMA ligands. In addition, we summarize various findings regarding the efficacy and problems of PSMA-RLT and discuss the optimal patient for PSMA-RLT.
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spelling pubmed-104538752023-08-26 PSMA Targeted Molecular Imaging and Radioligand Therapy for Prostate Cancer: Optimal Patient and Treatment Issues Hoshi, Seiji Yaginuma, Kei Meguro, Satoru Onagi, Akifumi Matsuoka, Kanako Hata, Junya Sato, Yuichi Akaihata, Hidenori Kataoka, Masao Ogawa, Soichiro Uemura, Motohide Kojima, Yoshiyuki Curr Oncol Review Theranostics (therapy + diagnosis) targeting prostate-specific membrane antigen (PSMA) is an emerging therapeutic modality that could alter treatment strategies for prostate cancer. Although PSMA-targeted radioligand therapy (PSMA-RLT) has a highly therapeutic effect on PSMA-positive tumor tissue, the efficacy of PSMA-RLT depends on PSMA expression. Moreover, predictors of treatment response other than PSMA expression are under investigation. Therefore, the optimal patient population for PSMA-RLT remains unclear. This review provides an overview of the current status of theranostics for prostate cancer, focusing on PSMA ligands. In addition, we summarize various findings regarding the efficacy and problems of PSMA-RLT and discuss the optimal patient for PSMA-RLT. MDPI 2023-08-01 /pmc/articles/PMC10453875/ /pubmed/37623010 http://dx.doi.org/10.3390/curroncol30080529 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hoshi, Seiji
Yaginuma, Kei
Meguro, Satoru
Onagi, Akifumi
Matsuoka, Kanako
Hata, Junya
Sato, Yuichi
Akaihata, Hidenori
Kataoka, Masao
Ogawa, Soichiro
Uemura, Motohide
Kojima, Yoshiyuki
PSMA Targeted Molecular Imaging and Radioligand Therapy for Prostate Cancer: Optimal Patient and Treatment Issues
title PSMA Targeted Molecular Imaging and Radioligand Therapy for Prostate Cancer: Optimal Patient and Treatment Issues
title_full PSMA Targeted Molecular Imaging and Radioligand Therapy for Prostate Cancer: Optimal Patient and Treatment Issues
title_fullStr PSMA Targeted Molecular Imaging and Radioligand Therapy for Prostate Cancer: Optimal Patient and Treatment Issues
title_full_unstemmed PSMA Targeted Molecular Imaging and Radioligand Therapy for Prostate Cancer: Optimal Patient and Treatment Issues
title_short PSMA Targeted Molecular Imaging and Radioligand Therapy for Prostate Cancer: Optimal Patient and Treatment Issues
title_sort psma targeted molecular imaging and radioligand therapy for prostate cancer: optimal patient and treatment issues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453875/
https://www.ncbi.nlm.nih.gov/pubmed/37623010
http://dx.doi.org/10.3390/curroncol30080529
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