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Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review

This review aimed to investigate the metabolic alterations associated with psychopharmacological treatment of neuropsychiatric disorders, which can significantly impact patients’ physical health and overall quality of life. The study utilized the PRISMA methodology and included cross-sectional, retr...

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Autores principales: Sepúlveda-Lizcano, Lizeth, Arenas-Villamizar, Vivian Vanessa, Jaimes-Duarte, Enna Beatriz, García-Pacheco, Henry, Paredes, Carlos Silva, Bermúdez, Valmore, Rivera-Porras, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453914/
https://www.ncbi.nlm.nih.gov/pubmed/37623307
http://dx.doi.org/10.3390/ejihpe13080110
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author Sepúlveda-Lizcano, Lizeth
Arenas-Villamizar, Vivian Vanessa
Jaimes-Duarte, Enna Beatriz
García-Pacheco, Henry
Paredes, Carlos Silva
Bermúdez, Valmore
Rivera-Porras, Diego
author_facet Sepúlveda-Lizcano, Lizeth
Arenas-Villamizar, Vivian Vanessa
Jaimes-Duarte, Enna Beatriz
García-Pacheco, Henry
Paredes, Carlos Silva
Bermúdez, Valmore
Rivera-Porras, Diego
author_sort Sepúlveda-Lizcano, Lizeth
collection PubMed
description This review aimed to investigate the metabolic alterations associated with psychopharmacological treatment of neuropsychiatric disorders, which can significantly impact patients’ physical health and overall quality of life. The study utilized the PRISMA methodology and included cross-sectional, retrospective studies, and randomized clinical trials from reputable databases like SCOPUS, CLARIVATE, SCIENCE DIRECT, and PUBMED. Out of the 64 selected studies, various psychotropic drug classes were analyzed, including antidepressants, anticonvulsants, and antipsychotics. Among the antidepressants, such as amitriptyline, Imipramine, and clomipramine, weight gain, constipation, and cardiovascular effects were the most commonly reported metabolic adverse effects. SSRI antidepressants like Fluoxetine, Sertraline, Citalopram, Escitalopram, and Paroxetine exhibited a high prevalence of gastrointestinal and cardiac alterations. Regarding anticonvulsants, valproic acid and Fosphenytoin were associated with adverse reactions such as weight gain and disturbances in appetite and sleep patterns. As for antipsychotics, drugs like Clozapine, Olanzapine, and Risperidone were linked to weight gain, diabetes, and deterioration of the lipid profile. The findings of this review emphasize the importance of continuous monitoring for adverse effects, particularly considering that the metabolic changes caused by psychopharmacological medications may vary depending on the age of the patients. Future research should focus on conducting field studies to further expand knowledge on the metabolic effects of other commonly prescribed psychotropic drugs. Overall, the study highlights the significance of understanding and managing metabolic alterations induced by psychopharmacological treatment to enhance patient care and well-being.
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spelling pubmed-104539142023-08-26 Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review Sepúlveda-Lizcano, Lizeth Arenas-Villamizar, Vivian Vanessa Jaimes-Duarte, Enna Beatriz García-Pacheco, Henry Paredes, Carlos Silva Bermúdez, Valmore Rivera-Porras, Diego Eur J Investig Health Psychol Educ Systematic Review This review aimed to investigate the metabolic alterations associated with psychopharmacological treatment of neuropsychiatric disorders, which can significantly impact patients’ physical health and overall quality of life. The study utilized the PRISMA methodology and included cross-sectional, retrospective studies, and randomized clinical trials from reputable databases like SCOPUS, CLARIVATE, SCIENCE DIRECT, and PUBMED. Out of the 64 selected studies, various psychotropic drug classes were analyzed, including antidepressants, anticonvulsants, and antipsychotics. Among the antidepressants, such as amitriptyline, Imipramine, and clomipramine, weight gain, constipation, and cardiovascular effects were the most commonly reported metabolic adverse effects. SSRI antidepressants like Fluoxetine, Sertraline, Citalopram, Escitalopram, and Paroxetine exhibited a high prevalence of gastrointestinal and cardiac alterations. Regarding anticonvulsants, valproic acid and Fosphenytoin were associated with adverse reactions such as weight gain and disturbances in appetite and sleep patterns. As for antipsychotics, drugs like Clozapine, Olanzapine, and Risperidone were linked to weight gain, diabetes, and deterioration of the lipid profile. The findings of this review emphasize the importance of continuous monitoring for adverse effects, particularly considering that the metabolic changes caused by psychopharmacological medications may vary depending on the age of the patients. Future research should focus on conducting field studies to further expand knowledge on the metabolic effects of other commonly prescribed psychotropic drugs. Overall, the study highlights the significance of understanding and managing metabolic alterations induced by psychopharmacological treatment to enhance patient care and well-being. MDPI 2023-08-12 /pmc/articles/PMC10453914/ /pubmed/37623307 http://dx.doi.org/10.3390/ejihpe13080110 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Sepúlveda-Lizcano, Lizeth
Arenas-Villamizar, Vivian Vanessa
Jaimes-Duarte, Enna Beatriz
García-Pacheco, Henry
Paredes, Carlos Silva
Bermúdez, Valmore
Rivera-Porras, Diego
Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review
title Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review
title_full Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review
title_fullStr Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review
title_full_unstemmed Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review
title_short Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review
title_sort metabolic adverse effects of psychotropic drug therapy: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10453914/
https://www.ncbi.nlm.nih.gov/pubmed/37623307
http://dx.doi.org/10.3390/ejihpe13080110
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