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Plasma Lipids Profile in the Prediction of Non-Alcoholic Steatohepatitis in Adults: A Case-Control Study

Patients with non-alcoholic steatohepatitis (NASH) show significantly faster progress in the stages of fibrosis compared to those with non-alcoholic fatty liver (NAFL) disease. The non-invasive diagnosis of NASH remains an unmet clinical need. Preliminary data have shown that sphingolipids, especial...

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Autores principales: Kalopitas, Georgios, Mouskeftara, Thomai, Liapikos, Theodoros, Arvanitakis, Konstantinos, Ioannidis, Aristeidis, Malandris, Konstantinos, Theocharidou, Eleni, Chourdakis, Michail, Sinakos, Emmanouil, Gika, Helen, Germanidis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454013/
https://www.ncbi.nlm.nih.gov/pubmed/37628898
http://dx.doi.org/10.3390/ijms241612717
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author Kalopitas, Georgios
Mouskeftara, Thomai
Liapikos, Theodoros
Arvanitakis, Konstantinos
Ioannidis, Aristeidis
Malandris, Konstantinos
Theocharidou, Eleni
Chourdakis, Michail
Sinakos, Emmanouil
Gika, Helen
Germanidis, Georgios
author_facet Kalopitas, Georgios
Mouskeftara, Thomai
Liapikos, Theodoros
Arvanitakis, Konstantinos
Ioannidis, Aristeidis
Malandris, Konstantinos
Theocharidou, Eleni
Chourdakis, Michail
Sinakos, Emmanouil
Gika, Helen
Germanidis, Georgios
author_sort Kalopitas, Georgios
collection PubMed
description Patients with non-alcoholic steatohepatitis (NASH) show significantly faster progress in the stages of fibrosis compared to those with non-alcoholic fatty liver (NAFL) disease. The non-invasive diagnosis of NASH remains an unmet clinical need. Preliminary data have shown that sphingolipids, especially ceramides, fatty acids, and other lipid classes may be related to the presence of NASH and the histological activity of the disease. The aim of our study was to assess the association of certain plasma lipid classes, such as fatty acids, acylcarnitines, and ceramides, with the histopathological findings in patients with NASH. The study included three groups: patients with NASH (N = 12), NAFL (N = 10), and healthy [non non-alcoholic fatty liver disease (NAFLD)] controls (N = 15). Plasma samples were collected after 12 h of fasting, and targeted analyses for fatty acids, acylcarnitines, and ceramides were performed. Baseline clinical and demographic characteristics were collected. There was no significant difference in baseline characteristics across the three groups or between NAFL and NASH patients. Patients with NASH had increased levels of several fatty acids, including, among others, fatty acid (FA) 14:0, FA 15:0, FA 18:0, FA 18:3n3, as well as Cer(d18:1/16:0), compared to NAFL patients and healthy controls. No significant difference was found between NAFL patients and healthy controls. In conclusion, patients with NASH exhibited a distinctive plasma lipid profile that can differentiate them from NAFL patients and non-NAFLD populations. More data from larger cohorts are needed to validate these findings and examine possible implications for diagnostic and management strategies of the disease.
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spelling pubmed-104540132023-08-26 Plasma Lipids Profile in the Prediction of Non-Alcoholic Steatohepatitis in Adults: A Case-Control Study Kalopitas, Georgios Mouskeftara, Thomai Liapikos, Theodoros Arvanitakis, Konstantinos Ioannidis, Aristeidis Malandris, Konstantinos Theocharidou, Eleni Chourdakis, Michail Sinakos, Emmanouil Gika, Helen Germanidis, Georgios Int J Mol Sci Article Patients with non-alcoholic steatohepatitis (NASH) show significantly faster progress in the stages of fibrosis compared to those with non-alcoholic fatty liver (NAFL) disease. The non-invasive diagnosis of NASH remains an unmet clinical need. Preliminary data have shown that sphingolipids, especially ceramides, fatty acids, and other lipid classes may be related to the presence of NASH and the histological activity of the disease. The aim of our study was to assess the association of certain plasma lipid classes, such as fatty acids, acylcarnitines, and ceramides, with the histopathological findings in patients with NASH. The study included three groups: patients with NASH (N = 12), NAFL (N = 10), and healthy [non non-alcoholic fatty liver disease (NAFLD)] controls (N = 15). Plasma samples were collected after 12 h of fasting, and targeted analyses for fatty acids, acylcarnitines, and ceramides were performed. Baseline clinical and demographic characteristics were collected. There was no significant difference in baseline characteristics across the three groups or between NAFL and NASH patients. Patients with NASH had increased levels of several fatty acids, including, among others, fatty acid (FA) 14:0, FA 15:0, FA 18:0, FA 18:3n3, as well as Cer(d18:1/16:0), compared to NAFL patients and healthy controls. No significant difference was found between NAFL patients and healthy controls. In conclusion, patients with NASH exhibited a distinctive plasma lipid profile that can differentiate them from NAFL patients and non-NAFLD populations. More data from larger cohorts are needed to validate these findings and examine possible implications for diagnostic and management strategies of the disease. MDPI 2023-08-12 /pmc/articles/PMC10454013/ /pubmed/37628898 http://dx.doi.org/10.3390/ijms241612717 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalopitas, Georgios
Mouskeftara, Thomai
Liapikos, Theodoros
Arvanitakis, Konstantinos
Ioannidis, Aristeidis
Malandris, Konstantinos
Theocharidou, Eleni
Chourdakis, Michail
Sinakos, Emmanouil
Gika, Helen
Germanidis, Georgios
Plasma Lipids Profile in the Prediction of Non-Alcoholic Steatohepatitis in Adults: A Case-Control Study
title Plasma Lipids Profile in the Prediction of Non-Alcoholic Steatohepatitis in Adults: A Case-Control Study
title_full Plasma Lipids Profile in the Prediction of Non-Alcoholic Steatohepatitis in Adults: A Case-Control Study
title_fullStr Plasma Lipids Profile in the Prediction of Non-Alcoholic Steatohepatitis in Adults: A Case-Control Study
title_full_unstemmed Plasma Lipids Profile in the Prediction of Non-Alcoholic Steatohepatitis in Adults: A Case-Control Study
title_short Plasma Lipids Profile in the Prediction of Non-Alcoholic Steatohepatitis in Adults: A Case-Control Study
title_sort plasma lipids profile in the prediction of non-alcoholic steatohepatitis in adults: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454013/
https://www.ncbi.nlm.nih.gov/pubmed/37628898
http://dx.doi.org/10.3390/ijms241612717
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