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The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases
The course of COVID-19 is highly dependent on the associated cardiometabolic comorbidities of the patient, which worsen the prognosis of coronavirus infection, mainly due to systemic inflammation, endothelium dysfunction, and thrombosis. A search on the recent medical literature was performed in fiv...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454092/ https://www.ncbi.nlm.nih.gov/pubmed/37628963 http://dx.doi.org/10.3390/ijms241612782 |
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author | Szilveszter, Mónika Pál, Sándor Simon-Szabó, Zsuzsánna Akácsos-Szász, Orsolya-Zsuzsa Moldován, Mihály Réger, Barbara Dénes, Lóránd Faust, Zsuzsanna Tilinca, Mariana Cornelia Nemes-Nagy, Enikő |
author_facet | Szilveszter, Mónika Pál, Sándor Simon-Szabó, Zsuzsánna Akácsos-Szász, Orsolya-Zsuzsa Moldován, Mihály Réger, Barbara Dénes, Lóránd Faust, Zsuzsanna Tilinca, Mariana Cornelia Nemes-Nagy, Enikő |
author_sort | Szilveszter, Mónika |
collection | PubMed |
description | The course of COVID-19 is highly dependent on the associated cardiometabolic comorbidities of the patient, which worsen the prognosis of coronavirus infection, mainly due to systemic inflammation, endothelium dysfunction, and thrombosis. A search on the recent medical literature was performed in five languages, using the PubMed, Embase, Cochrane, and Google Scholar databases, for the review of data regarding the management of patients with a high risk for severe COVID-19, focusing on the associated coagulopathy. Special features of COVID-19 management are presented, based on the underlying conditions (obesity, diabetes mellitus, and cardiovascular diseases), emphasizing the necessity of a modern, holistic approach to thromboembolic states. The latest findings regarding the most efficient therapeutic approaches are included in the article, offering guidance for medical professionals in severe, complicated cases of SARS-CoV-2 infection. We can conclude that severe COVID-19 is closely related to vascular inflammation and intense cytokine release leading to hemostasis disorders. Overweight, hyperglycemia, cardiovascular diseases, and old age are important risk factors for severe outcomes of coronavirus infection, involving a hypercoagulable state. Early diagnosis and proper therapy in complicated SARS-CoV-2-infected cases could reduce mortality and the need for intensive care during hospitalization in patients with cardiometabolic comorbidities. |
format | Online Article Text |
id | pubmed-10454092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104540922023-08-26 The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases Szilveszter, Mónika Pál, Sándor Simon-Szabó, Zsuzsánna Akácsos-Szász, Orsolya-Zsuzsa Moldován, Mihály Réger, Barbara Dénes, Lóránd Faust, Zsuzsanna Tilinca, Mariana Cornelia Nemes-Nagy, Enikő Int J Mol Sci Review The course of COVID-19 is highly dependent on the associated cardiometabolic comorbidities of the patient, which worsen the prognosis of coronavirus infection, mainly due to systemic inflammation, endothelium dysfunction, and thrombosis. A search on the recent medical literature was performed in five languages, using the PubMed, Embase, Cochrane, and Google Scholar databases, for the review of data regarding the management of patients with a high risk for severe COVID-19, focusing on the associated coagulopathy. Special features of COVID-19 management are presented, based on the underlying conditions (obesity, diabetes mellitus, and cardiovascular diseases), emphasizing the necessity of a modern, holistic approach to thromboembolic states. The latest findings regarding the most efficient therapeutic approaches are included in the article, offering guidance for medical professionals in severe, complicated cases of SARS-CoV-2 infection. We can conclude that severe COVID-19 is closely related to vascular inflammation and intense cytokine release leading to hemostasis disorders. Overweight, hyperglycemia, cardiovascular diseases, and old age are important risk factors for severe outcomes of coronavirus infection, involving a hypercoagulable state. Early diagnosis and proper therapy in complicated SARS-CoV-2-infected cases could reduce mortality and the need for intensive care during hospitalization in patients with cardiometabolic comorbidities. MDPI 2023-08-14 /pmc/articles/PMC10454092/ /pubmed/37628963 http://dx.doi.org/10.3390/ijms241612782 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Szilveszter, Mónika Pál, Sándor Simon-Szabó, Zsuzsánna Akácsos-Szász, Orsolya-Zsuzsa Moldován, Mihály Réger, Barbara Dénes, Lóránd Faust, Zsuzsanna Tilinca, Mariana Cornelia Nemes-Nagy, Enikő The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases |
title | The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases |
title_full | The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases |
title_fullStr | The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases |
title_full_unstemmed | The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases |
title_short | The Management of COVID-19-Related Coagulopathy: A Focus on the Challenges of Metabolic and Vascular Diseases |
title_sort | management of covid-19-related coagulopathy: a focus on the challenges of metabolic and vascular diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454092/ https://www.ncbi.nlm.nih.gov/pubmed/37628963 http://dx.doi.org/10.3390/ijms241612782 |
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