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The Roles of Periodontal Bacteria in Atherosclerosis
Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susce...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454115/ https://www.ncbi.nlm.nih.gov/pubmed/37629042 http://dx.doi.org/10.3390/ijms241612861 |
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author | Huang, Xiaofei Xie, Mengru Lu, Xiaofeng Mei, Feng Song, Wencheng Liu, Yang Chen, Lili |
author_facet | Huang, Xiaofei Xie, Mengru Lu, Xiaofeng Mei, Feng Song, Wencheng Liu, Yang Chen, Lili |
author_sort | Huang, Xiaofei |
collection | PubMed |
description | Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susceptibility to AS and CVD. This review concisely outlines several prevalent periodontal pathogens identified within atherosclerotic plaques, including Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum. We review the existing epidemiological evidence elucidating the association between these pathogens and AS-related diseases, and the diverse mechanisms for which these pathogens may engage in AS, such as endothelial barrier disruption, immune system activation, facilitation of monocyte adhesion and aggregation, and promotion of foam cell formation, all of which contribute to the progression and destabilization of atherosclerotic plaques. Notably, the intricate interplay among bacteria underscores the complex impact of periodontitis on AS. In conclusion, advancing our understanding of the relationship between periodontal pathogens and AS will undoubtedly offer invaluable insights and potential therapeutic avenues for the prevention and management of AS. |
format | Online Article Text |
id | pubmed-10454115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104541152023-08-26 The Roles of Periodontal Bacteria in Atherosclerosis Huang, Xiaofei Xie, Mengru Lu, Xiaofeng Mei, Feng Song, Wencheng Liu, Yang Chen, Lili Int J Mol Sci Review Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susceptibility to AS and CVD. This review concisely outlines several prevalent periodontal pathogens identified within atherosclerotic plaques, including Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum. We review the existing epidemiological evidence elucidating the association between these pathogens and AS-related diseases, and the diverse mechanisms for which these pathogens may engage in AS, such as endothelial barrier disruption, immune system activation, facilitation of monocyte adhesion and aggregation, and promotion of foam cell formation, all of which contribute to the progression and destabilization of atherosclerotic plaques. Notably, the intricate interplay among bacteria underscores the complex impact of periodontitis on AS. In conclusion, advancing our understanding of the relationship between periodontal pathogens and AS will undoubtedly offer invaluable insights and potential therapeutic avenues for the prevention and management of AS. MDPI 2023-08-16 /pmc/articles/PMC10454115/ /pubmed/37629042 http://dx.doi.org/10.3390/ijms241612861 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Huang, Xiaofei Xie, Mengru Lu, Xiaofeng Mei, Feng Song, Wencheng Liu, Yang Chen, Lili The Roles of Periodontal Bacteria in Atherosclerosis |
title | The Roles of Periodontal Bacteria in Atherosclerosis |
title_full | The Roles of Periodontal Bacteria in Atherosclerosis |
title_fullStr | The Roles of Periodontal Bacteria in Atherosclerosis |
title_full_unstemmed | The Roles of Periodontal Bacteria in Atherosclerosis |
title_short | The Roles of Periodontal Bacteria in Atherosclerosis |
title_sort | roles of periodontal bacteria in atherosclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454115/ https://www.ncbi.nlm.nih.gov/pubmed/37629042 http://dx.doi.org/10.3390/ijms241612861 |
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