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The Roles of Periodontal Bacteria in Atherosclerosis

Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susce...

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Autores principales: Huang, Xiaofei, Xie, Mengru, Lu, Xiaofeng, Mei, Feng, Song, Wencheng, Liu, Yang, Chen, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454115/
https://www.ncbi.nlm.nih.gov/pubmed/37629042
http://dx.doi.org/10.3390/ijms241612861
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author Huang, Xiaofei
Xie, Mengru
Lu, Xiaofeng
Mei, Feng
Song, Wencheng
Liu, Yang
Chen, Lili
author_facet Huang, Xiaofei
Xie, Mengru
Lu, Xiaofeng
Mei, Feng
Song, Wencheng
Liu, Yang
Chen, Lili
author_sort Huang, Xiaofei
collection PubMed
description Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susceptibility to AS and CVD. This review concisely outlines several prevalent periodontal pathogens identified within atherosclerotic plaques, including Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum. We review the existing epidemiological evidence elucidating the association between these pathogens and AS-related diseases, and the diverse mechanisms for which these pathogens may engage in AS, such as endothelial barrier disruption, immune system activation, facilitation of monocyte adhesion and aggregation, and promotion of foam cell formation, all of which contribute to the progression and destabilization of atherosclerotic plaques. Notably, the intricate interplay among bacteria underscores the complex impact of periodontitis on AS. In conclusion, advancing our understanding of the relationship between periodontal pathogens and AS will undoubtedly offer invaluable insights and potential therapeutic avenues for the prevention and management of AS.
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spelling pubmed-104541152023-08-26 The Roles of Periodontal Bacteria in Atherosclerosis Huang, Xiaofei Xie, Mengru Lu, Xiaofeng Mei, Feng Song, Wencheng Liu, Yang Chen, Lili Int J Mol Sci Review Atherosclerosis (AS) is an inflammatory vascular disease that constitutes a major underlying cause of cardiovascular diseases (CVD) and stroke. Infection is a contributing risk factor for AS. Epidemiological evidence has implicated individuals afflicted by periodontitis displaying an increased susceptibility to AS and CVD. This review concisely outlines several prevalent periodontal pathogens identified within atherosclerotic plaques, including Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum. We review the existing epidemiological evidence elucidating the association between these pathogens and AS-related diseases, and the diverse mechanisms for which these pathogens may engage in AS, such as endothelial barrier disruption, immune system activation, facilitation of monocyte adhesion and aggregation, and promotion of foam cell formation, all of which contribute to the progression and destabilization of atherosclerotic plaques. Notably, the intricate interplay among bacteria underscores the complex impact of periodontitis on AS. In conclusion, advancing our understanding of the relationship between periodontal pathogens and AS will undoubtedly offer invaluable insights and potential therapeutic avenues for the prevention and management of AS. MDPI 2023-08-16 /pmc/articles/PMC10454115/ /pubmed/37629042 http://dx.doi.org/10.3390/ijms241612861 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huang, Xiaofei
Xie, Mengru
Lu, Xiaofeng
Mei, Feng
Song, Wencheng
Liu, Yang
Chen, Lili
The Roles of Periodontal Bacteria in Atherosclerosis
title The Roles of Periodontal Bacteria in Atherosclerosis
title_full The Roles of Periodontal Bacteria in Atherosclerosis
title_fullStr The Roles of Periodontal Bacteria in Atherosclerosis
title_full_unstemmed The Roles of Periodontal Bacteria in Atherosclerosis
title_short The Roles of Periodontal Bacteria in Atherosclerosis
title_sort roles of periodontal bacteria in atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454115/
https://www.ncbi.nlm.nih.gov/pubmed/37629042
http://dx.doi.org/10.3390/ijms241612861
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