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Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate

The accumulation of metabolic wastes in cell cultures can diminish product quality, reduce productivity, and trigger apoptosis. The limitation or removal of unintended waste products from Chinese hamster ovary (CHO) cell cultures has been attempted through multiple process and genetic engineering av...

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Detalles Bibliográficos
Autores principales:	Chitwood, Dylan G., Uy, Lisa, Fu, Wanfang, Klaubert, Stephanie R., Harcum, Sarah W., Saski, Christopher A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454118/ https://www.ncbi.nlm.nih.gov/pubmed/37628627 http://dx.doi.org/10.3390/genes14081576

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