Finding an Appropriate Mouse Model to Study the Impact of a Treatment for Friedreich Ataxia on the Behavioral Phenotype

Friedreich ataxia (FRDA) is a progressive neurodegenerative disease caused by a GAA repeat in the intron 1 of the frataxin gene (FXN) leading to a lower expression of the frataxin protein. The YG8sR mice are Knock-Out (KO) for their murine frataxin gene but contain a human frataxin transgene derived...

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Detalles Bibliográficos
Autores principales: Bouchard, Camille, Gérard, Catherine, Yanyabé, Solange Gni-fiene, Majeau, Nathalie, Aloui, Malek, Buisson, Gabrielle, Yameogo, Pouiré, Couture, Vanessa, Tremblay, Jacques P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454134/
https://www.ncbi.nlm.nih.gov/pubmed/37628705
http://dx.doi.org/10.3390/genes14081654

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