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MiRNA-146a—A Key Player in Immunity and Diseases

miRNA-146a, a single-stranded, non-coding RNA molecule, has emerged as a valuable diagnostic and prognostic biomarker for numerous pathological conditions. Its primary function lies in regulating inflammatory processes, haemopoiesis, allergic responses, and other key aspects of the innate immune sys...

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Autores principales: Gilyazova, Irina, Asadullina, Dilara, Kagirova, Evelina, Sikka, Ruhi, Mustafin, Artur, Ivanova, Elizaveta, Bakhtiyarova, Ksenia, Gilyazova, Gulshat, Gupta, Saurabh, Khusnutdinova, Elza, Gupta, Himanshu, Pavlov, Valentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454149/
https://www.ncbi.nlm.nih.gov/pubmed/37628949
http://dx.doi.org/10.3390/ijms241612767
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author Gilyazova, Irina
Asadullina, Dilara
Kagirova, Evelina
Sikka, Ruhi
Mustafin, Artur
Ivanova, Elizaveta
Bakhtiyarova, Ksenia
Gilyazova, Gulshat
Gupta, Saurabh
Khusnutdinova, Elza
Gupta, Himanshu
Pavlov, Valentin
author_facet Gilyazova, Irina
Asadullina, Dilara
Kagirova, Evelina
Sikka, Ruhi
Mustafin, Artur
Ivanova, Elizaveta
Bakhtiyarova, Ksenia
Gilyazova, Gulshat
Gupta, Saurabh
Khusnutdinova, Elza
Gupta, Himanshu
Pavlov, Valentin
author_sort Gilyazova, Irina
collection PubMed
description miRNA-146a, a single-stranded, non-coding RNA molecule, has emerged as a valuable diagnostic and prognostic biomarker for numerous pathological conditions. Its primary function lies in regulating inflammatory processes, haemopoiesis, allergic responses, and other key aspects of the innate immune system. Several studies have indicated that polymorphisms in miRNA-146a can influence the pathogenesis of various human diseases, including autoimmune disorders and cancer. One of the key mechanisms by which miRNA-146a exerts its effects is by controlling the expression of certain proteins involved in critical pathways. It can modulate the activity of interleukin-1 receptor-associated kinase, IRAK1, IRAK2 adaptor proteins, and tumour necrosis factor (TNF) targeting protein receptor 6, which is a regulator of the TNF signalling pathway. In addition, miRNA-146a affects gene expression through multiple signalling pathways, such as TNF, NF-κB and MEK-1/2, and JNK-1/2. Studies have been carried out to determine the effect of miRNA-146a on cancer pathogenesis, revealing its involvement in the synthesis of stem cells, which contributes to tumourigenesis. In this review, we focus on recent discoveries that highlight the significant role played by miRNA-146a in regulating various defence mechanisms and oncogenesis. The aim of this review article is to systematically examine miRNA-146a’s impact on the control of signalling pathways involved in oncopathology, immune system development, and the corresponding response to therapy.
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spelling pubmed-104541492023-08-26 MiRNA-146a—A Key Player in Immunity and Diseases Gilyazova, Irina Asadullina, Dilara Kagirova, Evelina Sikka, Ruhi Mustafin, Artur Ivanova, Elizaveta Bakhtiyarova, Ksenia Gilyazova, Gulshat Gupta, Saurabh Khusnutdinova, Elza Gupta, Himanshu Pavlov, Valentin Int J Mol Sci Review miRNA-146a, a single-stranded, non-coding RNA molecule, has emerged as a valuable diagnostic and prognostic biomarker for numerous pathological conditions. Its primary function lies in regulating inflammatory processes, haemopoiesis, allergic responses, and other key aspects of the innate immune system. Several studies have indicated that polymorphisms in miRNA-146a can influence the pathogenesis of various human diseases, including autoimmune disorders and cancer. One of the key mechanisms by which miRNA-146a exerts its effects is by controlling the expression of certain proteins involved in critical pathways. It can modulate the activity of interleukin-1 receptor-associated kinase, IRAK1, IRAK2 adaptor proteins, and tumour necrosis factor (TNF) targeting protein receptor 6, which is a regulator of the TNF signalling pathway. In addition, miRNA-146a affects gene expression through multiple signalling pathways, such as TNF, NF-κB and MEK-1/2, and JNK-1/2. Studies have been carried out to determine the effect of miRNA-146a on cancer pathogenesis, revealing its involvement in the synthesis of stem cells, which contributes to tumourigenesis. In this review, we focus on recent discoveries that highlight the significant role played by miRNA-146a in regulating various defence mechanisms and oncogenesis. The aim of this review article is to systematically examine miRNA-146a’s impact on the control of signalling pathways involved in oncopathology, immune system development, and the corresponding response to therapy. MDPI 2023-08-14 /pmc/articles/PMC10454149/ /pubmed/37628949 http://dx.doi.org/10.3390/ijms241612767 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gilyazova, Irina
Asadullina, Dilara
Kagirova, Evelina
Sikka, Ruhi
Mustafin, Artur
Ivanova, Elizaveta
Bakhtiyarova, Ksenia
Gilyazova, Gulshat
Gupta, Saurabh
Khusnutdinova, Elza
Gupta, Himanshu
Pavlov, Valentin
MiRNA-146a—A Key Player in Immunity and Diseases
title MiRNA-146a—A Key Player in Immunity and Diseases
title_full MiRNA-146a—A Key Player in Immunity and Diseases
title_fullStr MiRNA-146a—A Key Player in Immunity and Diseases
title_full_unstemmed MiRNA-146a—A Key Player in Immunity and Diseases
title_short MiRNA-146a—A Key Player in Immunity and Diseases
title_sort mirna-146a—a key player in immunity and diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454149/
https://www.ncbi.nlm.nih.gov/pubmed/37628949
http://dx.doi.org/10.3390/ijms241612767
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