Cargando…

Regenerating Myofibers after an Acute Muscle Injury: What Do We Really Know about Them?

Injury to skeletal muscle through trauma, physical activity, or disease initiates a process called muscle regeneration. When injured myofibers undergo necrosis, muscle regeneration gives rise to myofibers that have myonuclei in a central position, which contrasts the normal, peripheral position of m...

Descripción completa

Detalles Bibliográficos
Autores principales: Pizza, Francis X., Buckley, Kole H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454182/
https://www.ncbi.nlm.nih.gov/pubmed/37628725
http://dx.doi.org/10.3390/ijms241612545
_version_ 1785096126526914560
author Pizza, Francis X.
Buckley, Kole H.
author_facet Pizza, Francis X.
Buckley, Kole H.
author_sort Pizza, Francis X.
collection PubMed
description Injury to skeletal muscle through trauma, physical activity, or disease initiates a process called muscle regeneration. When injured myofibers undergo necrosis, muscle regeneration gives rise to myofibers that have myonuclei in a central position, which contrasts the normal, peripheral position of myonuclei. Myofibers with central myonuclei are called regenerating myofibers and are the hallmark feature of muscle regeneration. An important and underappreciated aspect of muscle regeneration is the maturation of regenerating myofibers into a normal sized myofiber with peripheral myonuclei. Strikingly, very little is known about processes that govern regenerating myofiber maturation after muscle injury. As knowledge of myofiber formation and maturation during embryonic, fetal, and postnatal development has served as a foundation for understanding muscle regeneration, this narrative review discusses similarities and differences in myofiber maturation during muscle development and regeneration. Specifically, we compare and contrast myonuclear positioning, myonuclear accretion, myofiber hypertrophy, and myofiber morphology during muscle development and regeneration. We also discuss regenerating myofibers in the context of different types of myofiber necrosis (complete and segmental) after muscle trauma and injurious contractions. The overall goal of the review is to provide a framework for identifying cellular and molecular processes of myofiber maturation that are unique to muscle regeneration.
format Online
Article
Text
id pubmed-10454182
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104541822023-08-26 Regenerating Myofibers after an Acute Muscle Injury: What Do We Really Know about Them? Pizza, Francis X. Buckley, Kole H. Int J Mol Sci Review Injury to skeletal muscle through trauma, physical activity, or disease initiates a process called muscle regeneration. When injured myofibers undergo necrosis, muscle regeneration gives rise to myofibers that have myonuclei in a central position, which contrasts the normal, peripheral position of myonuclei. Myofibers with central myonuclei are called regenerating myofibers and are the hallmark feature of muscle regeneration. An important and underappreciated aspect of muscle regeneration is the maturation of regenerating myofibers into a normal sized myofiber with peripheral myonuclei. Strikingly, very little is known about processes that govern regenerating myofiber maturation after muscle injury. As knowledge of myofiber formation and maturation during embryonic, fetal, and postnatal development has served as a foundation for understanding muscle regeneration, this narrative review discusses similarities and differences in myofiber maturation during muscle development and regeneration. Specifically, we compare and contrast myonuclear positioning, myonuclear accretion, myofiber hypertrophy, and myofiber morphology during muscle development and regeneration. We also discuss regenerating myofibers in the context of different types of myofiber necrosis (complete and segmental) after muscle trauma and injurious contractions. The overall goal of the review is to provide a framework for identifying cellular and molecular processes of myofiber maturation that are unique to muscle regeneration. MDPI 2023-08-08 /pmc/articles/PMC10454182/ /pubmed/37628725 http://dx.doi.org/10.3390/ijms241612545 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pizza, Francis X.
Buckley, Kole H.
Regenerating Myofibers after an Acute Muscle Injury: What Do We Really Know about Them?
title Regenerating Myofibers after an Acute Muscle Injury: What Do We Really Know about Them?
title_full Regenerating Myofibers after an Acute Muscle Injury: What Do We Really Know about Them?
title_fullStr Regenerating Myofibers after an Acute Muscle Injury: What Do We Really Know about Them?
title_full_unstemmed Regenerating Myofibers after an Acute Muscle Injury: What Do We Really Know about Them?
title_short Regenerating Myofibers after an Acute Muscle Injury: What Do We Really Know about Them?
title_sort regenerating myofibers after an acute muscle injury: what do we really know about them?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454182/
https://www.ncbi.nlm.nih.gov/pubmed/37628725
http://dx.doi.org/10.3390/ijms241612545
work_keys_str_mv AT pizzafrancisx regeneratingmyofibersafteranacutemuscleinjurywhatdowereallyknowaboutthem
AT buckleykoleh regeneratingmyofibersafteranacutemuscleinjurywhatdowereallyknowaboutthem