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Neurovascular coupling in severe aortic valve stenosis
OBJECTIVES: Aortic stenosis (AS) is characterized by obstruction of blood outflow from the left ventricle, which can impair target organ perfusion such as the brain. We hypothesized that hemodynamic changes in AS may lead to dysfunction of cerebral blood flow regulatory mechanisms. The aim of our st...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454277/ https://www.ncbi.nlm.nih.gov/pubmed/37475651 http://dx.doi.org/10.1002/brb3.3155 |
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author | Ovsenik, Ana Podbregar, Matej Lakič, Nikola Brešar, Martin Boškoski, Pavle Verdenik, Ivan Fabjan, Andrej |
author_facet | Ovsenik, Ana Podbregar, Matej Lakič, Nikola Brešar, Martin Boškoski, Pavle Verdenik, Ivan Fabjan, Andrej |
author_sort | Ovsenik, Ana |
collection | PubMed |
description | OBJECTIVES: Aortic stenosis (AS) is characterized by obstruction of blood outflow from the left ventricle, which can impair target organ perfusion such as the brain. We hypothesized that hemodynamic changes in AS may lead to dysfunction of cerebral blood flow regulatory mechanisms. The aim of our study was to evaluate neurovascular coupling in patients with AS by Transcranial Doppler ultrasonography. METHODS: Neurovascular coupling was assessed using visually evoked cerebral blood flow velocity responses (VEFR) calculated as relative blood flow velocity changes in the posterior cerebral artery upon visual stimulation. We analyzed peak systolic, mean and end diastolic VEFR in 54 patients with severe AS and 43 controls in 10 consecutive cycles of visual stimulation. Repeated‐measures ANOVA test was used to compare cerebral hemodynamic data by group. RESULTS: Patients with AS had significantly higher peak systolic (12.9% ± 5.6% and 10.5% ± 4.5%; p = .009) and mean VEFR (14.4% ± 5.8% and 12.2% ± 4.9%; p = .021) compared to controls, whereas only a tendency for higher end diastolic VEFR was observed (16.7% ± 6.9% and 14.4% ± 6.2%; p = .061). CONCLUSION: We have shown for the first time that patients with severe AS exhibit higher VEFR than controls indicating dysregulation of neurovascular coupling, which can be one of the factors contributing to development of cognitive decline. |
format | Online Article Text |
id | pubmed-10454277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104542772023-08-26 Neurovascular coupling in severe aortic valve stenosis Ovsenik, Ana Podbregar, Matej Lakič, Nikola Brešar, Martin Boškoski, Pavle Verdenik, Ivan Fabjan, Andrej Brain Behav Original Articles OBJECTIVES: Aortic stenosis (AS) is characterized by obstruction of blood outflow from the left ventricle, which can impair target organ perfusion such as the brain. We hypothesized that hemodynamic changes in AS may lead to dysfunction of cerebral blood flow regulatory mechanisms. The aim of our study was to evaluate neurovascular coupling in patients with AS by Transcranial Doppler ultrasonography. METHODS: Neurovascular coupling was assessed using visually evoked cerebral blood flow velocity responses (VEFR) calculated as relative blood flow velocity changes in the posterior cerebral artery upon visual stimulation. We analyzed peak systolic, mean and end diastolic VEFR in 54 patients with severe AS and 43 controls in 10 consecutive cycles of visual stimulation. Repeated‐measures ANOVA test was used to compare cerebral hemodynamic data by group. RESULTS: Patients with AS had significantly higher peak systolic (12.9% ± 5.6% and 10.5% ± 4.5%; p = .009) and mean VEFR (14.4% ± 5.8% and 12.2% ± 4.9%; p = .021) compared to controls, whereas only a tendency for higher end diastolic VEFR was observed (16.7% ± 6.9% and 14.4% ± 6.2%; p = .061). CONCLUSION: We have shown for the first time that patients with severe AS exhibit higher VEFR than controls indicating dysregulation of neurovascular coupling, which can be one of the factors contributing to development of cognitive decline. John Wiley and Sons Inc. 2023-07-21 /pmc/articles/PMC10454277/ /pubmed/37475651 http://dx.doi.org/10.1002/brb3.3155 Text en © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Ovsenik, Ana Podbregar, Matej Lakič, Nikola Brešar, Martin Boškoski, Pavle Verdenik, Ivan Fabjan, Andrej Neurovascular coupling in severe aortic valve stenosis |
title | Neurovascular coupling in severe aortic valve stenosis |
title_full | Neurovascular coupling in severe aortic valve stenosis |
title_fullStr | Neurovascular coupling in severe aortic valve stenosis |
title_full_unstemmed | Neurovascular coupling in severe aortic valve stenosis |
title_short | Neurovascular coupling in severe aortic valve stenosis |
title_sort | neurovascular coupling in severe aortic valve stenosis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454277/ https://www.ncbi.nlm.nih.gov/pubmed/37475651 http://dx.doi.org/10.1002/brb3.3155 |
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