The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma

Pancreatic cancer (PC) is the seventh leading cause of cancer-related death. PC incidence has continued to increase by about 1% each year in both men and women. Although the 5-year relative survival rate of PC has increased from 3% to 12%, it is still the lowest among cancers. Hence, novel therapeut...

Descripción completa

Detalles Bibliográficos
Autores principales: Giansante, Valentina, Stati, Gianmarco, Sancilio, Silvia, Guerra, Emanuela, Alberti, Saverio, Di Pietro, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454309/
https://www.ncbi.nlm.nih.gov/pubmed/37628814
http://dx.doi.org/10.3390/ijms241612633
_version_ 1785096161070153728
author Giansante, Valentina
Stati, Gianmarco
Sancilio, Silvia
Guerra, Emanuela
Alberti, Saverio
Di Pietro, Roberta
author_facet Giansante, Valentina
Stati, Gianmarco
Sancilio, Silvia
Guerra, Emanuela
Alberti, Saverio
Di Pietro, Roberta
author_sort Giansante, Valentina
collection PubMed
description Pancreatic cancer (PC) is the seventh leading cause of cancer-related death. PC incidence has continued to increase by about 1% each year in both men and women. Although the 5-year relative survival rate of PC has increased from 3% to 12%, it is still the lowest among cancers. Hence, novel therapeutic strategies are urgently needed. Challenges in PC-targeted therapeutic strategies stem from the high PC heterogeneity and from the poorly understood interplay between cancer cells and the surrounding microenvironment. Signaling pathways that drive PC cell growth have been the subject of intense scrutiny and interest has been attracted by necroptosis, a distinct type of programmed cell death. In this review, we provide a historical background on necroptosis and a detailed analysis of the ongoing debate on the role of necroptosis in PC malignant progression.
format Online
Article
Text
id pubmed-10454309
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104543092023-08-26 The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma Giansante, Valentina Stati, Gianmarco Sancilio, Silvia Guerra, Emanuela Alberti, Saverio Di Pietro, Roberta Int J Mol Sci Review Pancreatic cancer (PC) is the seventh leading cause of cancer-related death. PC incidence has continued to increase by about 1% each year in both men and women. Although the 5-year relative survival rate of PC has increased from 3% to 12%, it is still the lowest among cancers. Hence, novel therapeutic strategies are urgently needed. Challenges in PC-targeted therapeutic strategies stem from the high PC heterogeneity and from the poorly understood interplay between cancer cells and the surrounding microenvironment. Signaling pathways that drive PC cell growth have been the subject of intense scrutiny and interest has been attracted by necroptosis, a distinct type of programmed cell death. In this review, we provide a historical background on necroptosis and a detailed analysis of the ongoing debate on the role of necroptosis in PC malignant progression. MDPI 2023-08-10 /pmc/articles/PMC10454309/ /pubmed/37628814 http://dx.doi.org/10.3390/ijms241612633 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giansante, Valentina
Stati, Gianmarco
Sancilio, Silvia
Guerra, Emanuela
Alberti, Saverio
Di Pietro, Roberta
The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma
title The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma
title_full The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma
title_fullStr The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma
title_full_unstemmed The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma
title_short The Dual Role of Necroptosis in Pancreatic Ductal Adenocarcinoma
title_sort dual role of necroptosis in pancreatic ductal adenocarcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454309/
https://www.ncbi.nlm.nih.gov/pubmed/37628814
http://dx.doi.org/10.3390/ijms241612633
work_keys_str_mv AT giansantevalentina thedualroleofnecroptosisinpancreaticductaladenocarcinoma
AT statigianmarco thedualroleofnecroptosisinpancreaticductaladenocarcinoma
AT sanciliosilvia thedualroleofnecroptosisinpancreaticductaladenocarcinoma
AT guerraemanuela thedualroleofnecroptosisinpancreaticductaladenocarcinoma
AT albertisaverio thedualroleofnecroptosisinpancreaticductaladenocarcinoma
AT dipietroroberta thedualroleofnecroptosisinpancreaticductaladenocarcinoma
AT giansantevalentina dualroleofnecroptosisinpancreaticductaladenocarcinoma
AT statigianmarco dualroleofnecroptosisinpancreaticductaladenocarcinoma
AT sanciliosilvia dualroleofnecroptosisinpancreaticductaladenocarcinoma
AT guerraemanuela dualroleofnecroptosisinpancreaticductaladenocarcinoma
AT albertisaverio dualroleofnecroptosisinpancreaticductaladenocarcinoma
AT dipietroroberta dualroleofnecroptosisinpancreaticductaladenocarcinoma

Ejemplares similares