The 3′ Non-Coding Sequence Negatively Regulates PD-L1 Expression, and Its Regulators Are Systematically Identified in Pan-Cancer

The 3′-untranslated region (3′-UTR) of PD-L1 is significantly longer than the coding sequences (CDSs). However, its role and regulators have been little studied. We deleted whole 3′-UTR region by CRISPR-Cas9. Prognostic analysis was performed using online tools. Immune infiltration analysis was perf...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Zike, Pi, Hui, Zheng, Wen, Guo, Xiaohong, Shi, Conglin, Wang, Zhiyang, Zhang, Jie, Qu, Xuanhao, Liu, Lehan, Shen, Haoliang, Lu, Yang, Chen, Miaomiao, Zhang, Weibing, Sun, Rong, Fan, Yihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454350/
https://www.ncbi.nlm.nih.gov/pubmed/37628671
http://dx.doi.org/10.3390/genes14081620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454350/
https://www.ncbi.nlm.nih.gov/pubmed/37628671
http://dx.doi.org/10.3390/genes14081620

Ejemplares similares