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The 3′ Non-Coding Sequence Negatively Regulates PD-L1 Expression, and Its Regulators Are Systematically Identified in Pan-Cancer
The 3′-untranslated region (3′-UTR) of PD-L1 is significantly longer than the coding sequences (CDSs). However, its role and regulators have been little studied. We deleted whole 3′-UTR region by CRISPR-Cas9. Prognostic analysis was performed using online tools. Immune infiltration analysis was perf...
Autores principales: | Chen, Zike, Pi, Hui, Zheng, Wen, Guo, Xiaohong, Shi, Conglin, Wang, Zhiyang, Zhang, Jie, Qu, Xuanhao, Liu, Lehan, Shen, Haoliang, Lu, Yang, Chen, Miaomiao, Zhang, Weibing, Sun, Rong, Fan, Yihui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454350/ https://www.ncbi.nlm.nih.gov/pubmed/37628671 http://dx.doi.org/10.3390/genes14081620 |
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