Cargando…

The 3′ Non-Coding Sequence Negatively Regulates PD-L1 Expression, and Its Regulators Are Systematically Identified in Pan-Cancer

The 3′-untranslated region (3′-UTR) of PD-L1 is significantly longer than the coding sequences (CDSs). However, its role and regulators have been little studied. We deleted whole 3′-UTR region by CRISPR-Cas9. Prognostic analysis was performed using online tools. Immune infiltration analysis was perf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zike, Pi, Hui, Zheng, Wen, Guo, Xiaohong, Shi, Conglin, Wang, Zhiyang, Zhang, Jie, Qu, Xuanhao, Liu, Lehan, Shen, Haoliang, Lu, Yang, Chen, Miaomiao, Zhang, Weibing, Sun, Rong, Fan, Yihui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454350/ https://www.ncbi.nlm.nih.gov/pubmed/37628671 http://dx.doi.org/10.3390/genes14081620

Ejemplares similares

Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
por: Shi, Conglin, et al.
Publicado: (2023)

Hyperprogressive Disease Caused by PD-1 Inhibitors for the Treatment of Pan-Cancer
por: Chen, Shiyun, et al.
Publicado: (2021)

Knockdown of long non-coding RNA Taurine Up-Regulated 1 inhibited doxorubicin resistance of bladder urothelial carcinoma via Wnt/β-catenin pathway
por: Xie, Dalong, et al.
Publicado: (2017)

BATF Potentially Mediates Negative Regulation of PD-1/PD-Ls Pathway on T Cell Functions in Mycobacterium tuberculosis Infection
por: Liu, Qianqian, et al.
Publicado: (2019)

EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma
por: Xiao, Gang, et al.
Publicado: (2019)

The Structure of the PanD/PanZ Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A
por: Monteiro, Diana C.F., et al.
Publicado: (2015)

The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation
por: Fan, Zhiwei, et al.
Publicado: (2022)

Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma
por: He, Gaixia, et al.
Publicado: (2015)

PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow
por: Yu, Yao, et al.
Publicado: (2022)

PD-1/PD-L1 regulates Treg differentiation in pregnancy-induced hypertension
por: Jiang, Lai, et al.
Publicado: (2018)

PD-1 Alleviates Cisplatin-Induced Muscle Atrophy by Regulating Inflammation and Oxidative Stress
por: Liu, Xiaoguang, et al.
Publicado: (2022)

Long non-coding RNAs as pan-cancer master gene regulators of associated protein-coding genes: a systems biology approach
por: Saleembhasha, Asanigari, et al.
Publicado: (2019)

Global research trends on anti-PD-1/anti-PD-L1 immunotherapy for triple-negative breast cancer: A scientometric analysis
por: Wu, Jinyao, et al.
Publicado: (2023)

PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling
por: Gao, Hongmin, et al.
Publicado: (2019)

Regulation, genomics, and clinical characteristics of cuproptosis regulators in pan-cancer
por: Zhou, Cankun, et al.
Publicado: (2022)

Mechanism and Function of Circular RNA in Regulating Solid Tumor Radiosensitivity
por: Huang, Junchao, et al.
Publicado: (2022)

Pan-cancer analysis of long non-coding RNA NEAT1 in various cancers
por: Li, Shufen, et al.
Publicado: (2017)

Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators
por: Le Mercier, Isabelle, et al.
Publicado: (2015)

Enhancing the activity of Pd ensembles on graphene by manipulating coordination environment
por: Huang, Dahong, et al.
Publicado: (2023)

BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti‐PD‐1/PD‐L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity
por: Cai, Zhiyong, et al.
Publicado: (2023)

DNMT1 is a negative regulator of osteogenesis
por: Tao, Chen, et al.
Publicado: (2022)

Role of regulation of PD-1 and PD-L1 expression in sepsis
por: Zhang, Teng, et al.
Publicado: (2023)

Pan‐tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation
por: Li, Yisheng, et al.
Publicado: (2020)

Negative regulation of the interferon response by an interferon-induced long non-coding RNA
por: Kambara, Hiroto, et al.
Publicado: (2014)

Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression
por: Li, Jing, et al.
Publicado: (2015)

A pan-cancer study of PD-1 and CTLA-4 as therapeutic targets
por: Cai, Zongqiang, et al.
Publicado: (2021)

PD-L1: expression regulation
por: Zhou, Yu-Jie, et al.
Publicado: (2023)

4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis
por: Zhang, Peng, et al.
Publicado: (2022)

Blocking the PD-1/PD-L1 axis in dendritic cell-stimulated Cytokine-Induced Killer Cells with pembrolizumab enhances their therapeutic effects against hepatocellular carcinoma
por: Zhang, Wan, et al.
Publicado: (2019)

Tight junctions and their regulation by non-coding RNAs
por: Zhao, Xiaojiao, et al.
Publicado: (2021)

PD-L1 mediates triple-negative breast cancer evolution via the regulation of TAM/M2 polarization
por: Meng, Ziqi, et al.
Publicado: (2022)

Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators
por: Zhang, Jian, et al.
Publicado: (2021)

Regulator of cullins-1 (ROC1) negatively regulates the Gli2 regulator SUFU to activate the hedgehog pathway in bladder cancer
por: Wang, W., et al.
Publicado: (2021)

Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion
por: Liu, Kai, et al.
Publicado: (2016)

The long non-coding RNA LNC_000397 negatively regulates PRRSV replication through induction of interferon-stimulated genes
por: Zhang, Jing, et al.
Publicado: (2022)

The interaction between the soluble programmed death ligand-1 (sPD-L1) and PD-1(+) regulator B cells mediates immunosuppression in triple-negative breast cancer
por: Li, Xuejiao, et al.
Publicado: (2022)

Pd-doped HKUST-1 MOFs for enhanced hydrogen storage: effect of hydrogen spillover
por: Hu, Xiaoyu, et al.
Publicado: (2023)

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase
por: Fan, Yihui, et al.
Publicado: (2014)

PAN-cODE: COVID-19 forecasting using conditional latent ODEs
por: Shi, Ruian, et al.
Publicado: (2022)

Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the prognosis of cancer: a meta-analysis
por: Li, Yong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3r5dbq57mogteu8s0kggn41omv