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Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine

Systemic sclerosis, also known as scleroderma or SSc, is a condition characterized by significant heterogeneity in clinical presentation, disease progression, and response to treatment. Consequently, the design of clinical trials to successfully identify effective therapeutic interventions poses a m...

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Autores principales: Benfaremo, Devis, Agarbati, Silvia, Mozzicafreddo, Matteo, Paolini, Chiara, Svegliati, Silvia, Moroncini, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454358/
https://www.ncbi.nlm.nih.gov/pubmed/37628728
http://dx.doi.org/10.3390/ijms241612548
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author Benfaremo, Devis
Agarbati, Silvia
Mozzicafreddo, Matteo
Paolini, Chiara
Svegliati, Silvia
Moroncini, Gianluca
author_facet Benfaremo, Devis
Agarbati, Silvia
Mozzicafreddo, Matteo
Paolini, Chiara
Svegliati, Silvia
Moroncini, Gianluca
author_sort Benfaremo, Devis
collection PubMed
description Systemic sclerosis, also known as scleroderma or SSc, is a condition characterized by significant heterogeneity in clinical presentation, disease progression, and response to treatment. Consequently, the design of clinical trials to successfully identify effective therapeutic interventions poses a major challenge. Recent advancements in skin molecular profiling technologies and stratification techniques have enabled the identification of patient subgroups that may be relevant for personalized treatment approaches. This narrative review aims at providing an overview of the current status of skin gene expression analysis using computational biology approaches and highlights the benefits of stratifying patients upon their skin gene signatures. Such stratification has the potential to lead toward a precision medicine approach in the management of SSc.
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spelling pubmed-104543582023-08-26 Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine Benfaremo, Devis Agarbati, Silvia Mozzicafreddo, Matteo Paolini, Chiara Svegliati, Silvia Moroncini, Gianluca Int J Mol Sci Review Systemic sclerosis, also known as scleroderma or SSc, is a condition characterized by significant heterogeneity in clinical presentation, disease progression, and response to treatment. Consequently, the design of clinical trials to successfully identify effective therapeutic interventions poses a major challenge. Recent advancements in skin molecular profiling technologies and stratification techniques have enabled the identification of patient subgroups that may be relevant for personalized treatment approaches. This narrative review aims at providing an overview of the current status of skin gene expression analysis using computational biology approaches and highlights the benefits of stratifying patients upon their skin gene signatures. Such stratification has the potential to lead toward a precision medicine approach in the management of SSc. MDPI 2023-08-08 /pmc/articles/PMC10454358/ /pubmed/37628728 http://dx.doi.org/10.3390/ijms241612548 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Benfaremo, Devis
Agarbati, Silvia
Mozzicafreddo, Matteo
Paolini, Chiara
Svegliati, Silvia
Moroncini, Gianluca
Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine
title Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine
title_full Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine
title_fullStr Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine
title_full_unstemmed Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine
title_short Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine
title_sort skin gene expression profiles in systemic sclerosis: from clinical stratification to precision medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454358/
https://www.ncbi.nlm.nih.gov/pubmed/37628728
http://dx.doi.org/10.3390/ijms241612548
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