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Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine
Systemic sclerosis, also known as scleroderma or SSc, is a condition characterized by significant heterogeneity in clinical presentation, disease progression, and response to treatment. Consequently, the design of clinical trials to successfully identify effective therapeutic interventions poses a m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454358/ https://www.ncbi.nlm.nih.gov/pubmed/37628728 http://dx.doi.org/10.3390/ijms241612548 |
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author | Benfaremo, Devis Agarbati, Silvia Mozzicafreddo, Matteo Paolini, Chiara Svegliati, Silvia Moroncini, Gianluca |
author_facet | Benfaremo, Devis Agarbati, Silvia Mozzicafreddo, Matteo Paolini, Chiara Svegliati, Silvia Moroncini, Gianluca |
author_sort | Benfaremo, Devis |
collection | PubMed |
description | Systemic sclerosis, also known as scleroderma or SSc, is a condition characterized by significant heterogeneity in clinical presentation, disease progression, and response to treatment. Consequently, the design of clinical trials to successfully identify effective therapeutic interventions poses a major challenge. Recent advancements in skin molecular profiling technologies and stratification techniques have enabled the identification of patient subgroups that may be relevant for personalized treatment approaches. This narrative review aims at providing an overview of the current status of skin gene expression analysis using computational biology approaches and highlights the benefits of stratifying patients upon their skin gene signatures. Such stratification has the potential to lead toward a precision medicine approach in the management of SSc. |
format | Online Article Text |
id | pubmed-10454358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104543582023-08-26 Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine Benfaremo, Devis Agarbati, Silvia Mozzicafreddo, Matteo Paolini, Chiara Svegliati, Silvia Moroncini, Gianluca Int J Mol Sci Review Systemic sclerosis, also known as scleroderma or SSc, is a condition characterized by significant heterogeneity in clinical presentation, disease progression, and response to treatment. Consequently, the design of clinical trials to successfully identify effective therapeutic interventions poses a major challenge. Recent advancements in skin molecular profiling technologies and stratification techniques have enabled the identification of patient subgroups that may be relevant for personalized treatment approaches. This narrative review aims at providing an overview of the current status of skin gene expression analysis using computational biology approaches and highlights the benefits of stratifying patients upon their skin gene signatures. Such stratification has the potential to lead toward a precision medicine approach in the management of SSc. MDPI 2023-08-08 /pmc/articles/PMC10454358/ /pubmed/37628728 http://dx.doi.org/10.3390/ijms241612548 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Benfaremo, Devis Agarbati, Silvia Mozzicafreddo, Matteo Paolini, Chiara Svegliati, Silvia Moroncini, Gianluca Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine |
title | Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine |
title_full | Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine |
title_fullStr | Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine |
title_full_unstemmed | Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine |
title_short | Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine |
title_sort | skin gene expression profiles in systemic sclerosis: from clinical stratification to precision medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454358/ https://www.ncbi.nlm.nih.gov/pubmed/37628728 http://dx.doi.org/10.3390/ijms241612548 |
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