Hybrids of Sterically Hindered Phenols and Diaryl Ureas: Synthesis, Switch from Antioxidant Activity to ROS Generation and Induction of Apoptosis

The utility of sterically hindered phenols (SHPs) in drug design is based on their chameleonic ability to switch from an antioxidant that can protect healthy tissues to highly cytotoxic species that can target tumor cells. This work explores the biological activity of a family of 45 new hybrid molec...

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Detalles Bibliográficos
Autores principales: Gibadullina, Elmira, Neganova, Margarita, Aleksandrova, Yulia, Nguyen, Hoang Bao Tran, Voloshina, Alexandra, Khrizanforov, Mikhail, Nguyen, Thi Thu, Vinyukova, Ekaterina, Volcho, Konstantin, Tsypyshev, Dmitry, Lyubina, Anna, Amerhanova, Syumbelya, Strelnik, Anna, Voronina, Julia, Islamov, Daut, Zhapparbergenov, Rakhmetulla, Appazov, Nurbol, Chabuka, Beauty, Christopher, Kimberley, Burilov, Alexander, Salakhutdinov, Nariman, Sinyashin, Oleg, Alabugin, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454409/
https://www.ncbi.nlm.nih.gov/pubmed/37628818
http://dx.doi.org/10.3390/ijms241612637

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