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Purine Nucleotide Alterations in Tumoral Cell Lines Maintained with Physiological Levels of Folic Acid

Most cancer cells have an increased synthesis of purine nucleotides to fulfil their enhanced division rate. The de novo synthesis of purines requires folic acid in the form of N(10)-formyltetrahydrofolate (10-formyl-THF). However, regular cell culture media contain very high, non-physiological conce...

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Detalles Bibliográficos
Autores principales:	Cano-Estrada, Claudia, de Benito-Gómez, Lidia, Escudero-Ferruz, Paula, Ontiveros, Neus, Iglesias-Serret, Daniel, López, José M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454412/ https://www.ncbi.nlm.nih.gov/pubmed/37628755 http://dx.doi.org/10.3390/ijms241612573

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