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Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients

Despite the success of current therapy concepts, patients with advanced non-small-cell lung cancer (NSCLC) still have a very poor prognosis. Therefore, biological markers are urgently needed, which allow the assessment of prognosis, or prediction of the success of therapy or resistance in this disea...

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Autores principales: Bache, Matthias, Kadler, Frauke, Struck, Olivia, Medenwald, Daniel, Ostheimer, Christian, Güttler, Antje, Keßler, Jacqueline, Kappler, Matthias, Riemann, Anne, Thews, Oliver, Seliger, Barbara, Vordermark, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454434/
https://www.ncbi.nlm.nih.gov/pubmed/37629015
http://dx.doi.org/10.3390/ijms241612835
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author Bache, Matthias
Kadler, Frauke
Struck, Olivia
Medenwald, Daniel
Ostheimer, Christian
Güttler, Antje
Keßler, Jacqueline
Kappler, Matthias
Riemann, Anne
Thews, Oliver
Seliger, Barbara
Vordermark, Dirk
author_facet Bache, Matthias
Kadler, Frauke
Struck, Olivia
Medenwald, Daniel
Ostheimer, Christian
Güttler, Antje
Keßler, Jacqueline
Kappler, Matthias
Riemann, Anne
Thews, Oliver
Seliger, Barbara
Vordermark, Dirk
author_sort Bache, Matthias
collection PubMed
description Despite the success of current therapy concepts, patients with advanced non-small-cell lung cancer (NSCLC) still have a very poor prognosis. Therefore, biological markers are urgently needed, which allow the assessment of prognosis, or prediction of the success of therapy or resistance in this disease. Circulating microRNAs (miRs) have potential as biomarkers for the prognosis and prediction of response to therapy in cancer patients. Based on recent evidence that circulating miR-16, miR-29a, miR-144 and miR-150 can be regulated by ionizing radiation, the concentration of these four miRs was assessed in the plasma of NSCLC patients at different time points of radiotherapy by digital droplet PCR (ddPCR). Furthermore, their impact on patients’ prognosis was evaluated. The mean plasma levels of miR-16, miR-29a, miR-144 and miR-150 significantly differed intra- and inter-individually, and during therapy in NSCLC patients, but showed a strong positive correlation. The individual plasma levels of miR-16, miR-29a and miR-144 had prognostic value in NSCLC patients during or at the end of radiotherapy in Cox’s regression models. NSCLC patients with low levels of these three miRs at the end of radiotherapy had the worst prognosis. However, miR-150 plasma levels and treatment-dependent changes were not predictive. In conclusion, circulating miR-16, miR-29a and miR-144, but not miR-150, have a prognostic value in NSCLC patients undergoing radiotherapy.
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spelling pubmed-104544342023-08-26 Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients Bache, Matthias Kadler, Frauke Struck, Olivia Medenwald, Daniel Ostheimer, Christian Güttler, Antje Keßler, Jacqueline Kappler, Matthias Riemann, Anne Thews, Oliver Seliger, Barbara Vordermark, Dirk Int J Mol Sci Article Despite the success of current therapy concepts, patients with advanced non-small-cell lung cancer (NSCLC) still have a very poor prognosis. Therefore, biological markers are urgently needed, which allow the assessment of prognosis, or prediction of the success of therapy or resistance in this disease. Circulating microRNAs (miRs) have potential as biomarkers for the prognosis and prediction of response to therapy in cancer patients. Based on recent evidence that circulating miR-16, miR-29a, miR-144 and miR-150 can be regulated by ionizing radiation, the concentration of these four miRs was assessed in the plasma of NSCLC patients at different time points of radiotherapy by digital droplet PCR (ddPCR). Furthermore, their impact on patients’ prognosis was evaluated. The mean plasma levels of miR-16, miR-29a, miR-144 and miR-150 significantly differed intra- and inter-individually, and during therapy in NSCLC patients, but showed a strong positive correlation. The individual plasma levels of miR-16, miR-29a and miR-144 had prognostic value in NSCLC patients during or at the end of radiotherapy in Cox’s regression models. NSCLC patients with low levels of these three miRs at the end of radiotherapy had the worst prognosis. However, miR-150 plasma levels and treatment-dependent changes were not predictive. In conclusion, circulating miR-16, miR-29a and miR-144, but not miR-150, have a prognostic value in NSCLC patients undergoing radiotherapy. MDPI 2023-08-16 /pmc/articles/PMC10454434/ /pubmed/37629015 http://dx.doi.org/10.3390/ijms241612835 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bache, Matthias
Kadler, Frauke
Struck, Olivia
Medenwald, Daniel
Ostheimer, Christian
Güttler, Antje
Keßler, Jacqueline
Kappler, Matthias
Riemann, Anne
Thews, Oliver
Seliger, Barbara
Vordermark, Dirk
Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients
title Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients
title_full Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients
title_fullStr Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients
title_full_unstemmed Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients
title_short Correlation between Circulating miR-16, miR-29a, miR-144 and miR-150, and the Radiotherapy Response and Survival of Non-Small-Cell Lung Cancer Patients
title_sort correlation between circulating mir-16, mir-29a, mir-144 and mir-150, and the radiotherapy response and survival of non-small-cell lung cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454434/
https://www.ncbi.nlm.nih.gov/pubmed/37629015
http://dx.doi.org/10.3390/ijms241612835
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