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Genetics of Functional Seizures; A Scoping Systematic Review

Background: Evidence on the genetics of functional seizures is scarce, and the purpose of the current scoping systematic review is to examine the existing evidence and propose how to advance the field. Methods: Web of science and MEDLINE were searched, from their initiation until May 2023. The follo...

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Autores principales: Asadi-Pooya, Ali A., Hallett, Mark, Mirzaei Damabi, Nafiseh, Fazelian Dehkordi, Khatereh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454456/
https://www.ncbi.nlm.nih.gov/pubmed/37628589
http://dx.doi.org/10.3390/genes14081537
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author Asadi-Pooya, Ali A.
Hallett, Mark
Mirzaei Damabi, Nafiseh
Fazelian Dehkordi, Khatereh
author_facet Asadi-Pooya, Ali A.
Hallett, Mark
Mirzaei Damabi, Nafiseh
Fazelian Dehkordi, Khatereh
author_sort Asadi-Pooya, Ali A.
collection PubMed
description Background: Evidence on the genetics of functional seizures is scarce, and the purpose of the current scoping systematic review is to examine the existing evidence and propose how to advance the field. Methods: Web of science and MEDLINE were searched, from their initiation until May 2023. The following key words were used: functional neurological disorder(s), psychogenic neurological disorder(s), functional movement disorder(s), psychogenic movement disorder(s), functional seizures(s), psychogenic seizure(s), nonepileptic seizure(s), dissociative seizure(s), or psychogenic nonepileptic seizure(s), AND, gene, genetic(s), polymorphism, genome, epigenetics, copy number variant, copy number variation(s), whole exome sequencing, or next-generation sequencing. Results: We identified three original studies. In one study, the authors observed that six (5.9%) patients with functional seizures carried pathogenic/likely pathogenic variants. In another study, the authors observed that, in functional seizures, there was a significant correlation with genes that are over-represented in adrenergic, serotonergic, oxytocin, opioid, and GABA receptor signaling pathways. In the third study, the authors observed that patients with functional seizures, as well as patients with depression, had significantly different genotypes in FKBP5 single nucleotide polymorphisms compared with controls. Conclusion: Future genetic investigations of patients with functional seizures would increase our understanding of the pathophysiological and neurobiological problems underlying this common neuropsychological stress-associated condition.
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spelling pubmed-104544562023-08-26 Genetics of Functional Seizures; A Scoping Systematic Review Asadi-Pooya, Ali A. Hallett, Mark Mirzaei Damabi, Nafiseh Fazelian Dehkordi, Khatereh Genes (Basel) Review Background: Evidence on the genetics of functional seizures is scarce, and the purpose of the current scoping systematic review is to examine the existing evidence and propose how to advance the field. Methods: Web of science and MEDLINE were searched, from their initiation until May 2023. The following key words were used: functional neurological disorder(s), psychogenic neurological disorder(s), functional movement disorder(s), psychogenic movement disorder(s), functional seizures(s), psychogenic seizure(s), nonepileptic seizure(s), dissociative seizure(s), or psychogenic nonepileptic seizure(s), AND, gene, genetic(s), polymorphism, genome, epigenetics, copy number variant, copy number variation(s), whole exome sequencing, or next-generation sequencing. Results: We identified three original studies. In one study, the authors observed that six (5.9%) patients with functional seizures carried pathogenic/likely pathogenic variants. In another study, the authors observed that, in functional seizures, there was a significant correlation with genes that are over-represented in adrenergic, serotonergic, oxytocin, opioid, and GABA receptor signaling pathways. In the third study, the authors observed that patients with functional seizures, as well as patients with depression, had significantly different genotypes in FKBP5 single nucleotide polymorphisms compared with controls. Conclusion: Future genetic investigations of patients with functional seizures would increase our understanding of the pathophysiological and neurobiological problems underlying this common neuropsychological stress-associated condition. MDPI 2023-07-27 /pmc/articles/PMC10454456/ /pubmed/37628589 http://dx.doi.org/10.3390/genes14081537 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Asadi-Pooya, Ali A.
Hallett, Mark
Mirzaei Damabi, Nafiseh
Fazelian Dehkordi, Khatereh
Genetics of Functional Seizures; A Scoping Systematic Review
title Genetics of Functional Seizures; A Scoping Systematic Review
title_full Genetics of Functional Seizures; A Scoping Systematic Review
title_fullStr Genetics of Functional Seizures; A Scoping Systematic Review
title_full_unstemmed Genetics of Functional Seizures; A Scoping Systematic Review
title_short Genetics of Functional Seizures; A Scoping Systematic Review
title_sort genetics of functional seizures; a scoping systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454456/
https://www.ncbi.nlm.nih.gov/pubmed/37628589
http://dx.doi.org/10.3390/genes14081537
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