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WSB1 Involvement in Prostate Cancer Progression
Prostate cancer (PC) is polygenic disease involving many genes, and more importantly a host of gene–gene interactions, including transcriptional factors. The WSB1 gene is a transcriptional target of numerous oncoproteins, and its dysregulation can contribute to tumor progression by abnormal activati...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454498/ https://www.ncbi.nlm.nih.gov/pubmed/37628609 http://dx.doi.org/10.3390/genes14081558 |
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author | Boldrini, Laura Bardi, Massimo |
author_facet | Boldrini, Laura Bardi, Massimo |
author_sort | Boldrini, Laura |
collection | PubMed |
description | Prostate cancer (PC) is polygenic disease involving many genes, and more importantly a host of gene–gene interactions, including transcriptional factors. The WSB1 gene is a transcriptional target of numerous oncoproteins, and its dysregulation can contribute to tumor progression by abnormal activation of targeted oncogenes. Using data from the Cancer Genome Atlas, we tested the possible involvement of WSB1 in PC progression. A multi-dimensional scaling (MDS) model was applied to clarify the association of WSB1 expression with other key genes, such as c-myc, ERG, Enhancer of Zeste 1 and 2 (EHZ1 and EZH2), WNT10a, and WNT 10b. An increased WSB1 expression was associated with higher PC grades and with a worse prognosis. It was also positively related to EZH1, EZH2, WNT10a, and WNT10b. Moreover, MDS showed the central role of WSB1 in influencing the other target genes by its central location on the map. Our study is the first to show a link between WSB1 expression and other genes involved in PC progression, suggesting a novel role for WSB1 in PC progression. This network between WSB1 and EZH2 through WNT/β-catenin may have an important role in PC progression, as suggested by the association between high WSB1 expression and unfavorable prognosis in our analysis. |
format | Online Article Text |
id | pubmed-10454498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104544982023-08-26 WSB1 Involvement in Prostate Cancer Progression Boldrini, Laura Bardi, Massimo Genes (Basel) Article Prostate cancer (PC) is polygenic disease involving many genes, and more importantly a host of gene–gene interactions, including transcriptional factors. The WSB1 gene is a transcriptional target of numerous oncoproteins, and its dysregulation can contribute to tumor progression by abnormal activation of targeted oncogenes. Using data from the Cancer Genome Atlas, we tested the possible involvement of WSB1 in PC progression. A multi-dimensional scaling (MDS) model was applied to clarify the association of WSB1 expression with other key genes, such as c-myc, ERG, Enhancer of Zeste 1 and 2 (EHZ1 and EZH2), WNT10a, and WNT 10b. An increased WSB1 expression was associated with higher PC grades and with a worse prognosis. It was also positively related to EZH1, EZH2, WNT10a, and WNT10b. Moreover, MDS showed the central role of WSB1 in influencing the other target genes by its central location on the map. Our study is the first to show a link between WSB1 expression and other genes involved in PC progression, suggesting a novel role for WSB1 in PC progression. This network between WSB1 and EZH2 through WNT/β-catenin may have an important role in PC progression, as suggested by the association between high WSB1 expression and unfavorable prognosis in our analysis. MDPI 2023-07-29 /pmc/articles/PMC10454498/ /pubmed/37628609 http://dx.doi.org/10.3390/genes14081558 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Boldrini, Laura Bardi, Massimo WSB1 Involvement in Prostate Cancer Progression |
title | WSB1 Involvement in Prostate Cancer Progression |
title_full | WSB1 Involvement in Prostate Cancer Progression |
title_fullStr | WSB1 Involvement in Prostate Cancer Progression |
title_full_unstemmed | WSB1 Involvement in Prostate Cancer Progression |
title_short | WSB1 Involvement in Prostate Cancer Progression |
title_sort | wsb1 involvement in prostate cancer progression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454498/ https://www.ncbi.nlm.nih.gov/pubmed/37628609 http://dx.doi.org/10.3390/genes14081558 |
work_keys_str_mv | AT boldrinilaura wsb1involvementinprostatecancerprogression AT bardimassimo wsb1involvementinprostatecancerprogression |