Cargando…

WSB1 Involvement in Prostate Cancer Progression

Prostate cancer (PC) is polygenic disease involving many genes, and more importantly a host of gene–gene interactions, including transcriptional factors. The WSB1 gene is a transcriptional target of numerous oncoproteins, and its dysregulation can contribute to tumor progression by abnormal activati...

Descripción completa

Detalles Bibliográficos
Autores principales: Boldrini, Laura, Bardi, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454498/
https://www.ncbi.nlm.nih.gov/pubmed/37628609
http://dx.doi.org/10.3390/genes14081558
_version_ 1785096208384000000
author Boldrini, Laura
Bardi, Massimo
author_facet Boldrini, Laura
Bardi, Massimo
author_sort Boldrini, Laura
collection PubMed
description Prostate cancer (PC) is polygenic disease involving many genes, and more importantly a host of gene–gene interactions, including transcriptional factors. The WSB1 gene is a transcriptional target of numerous oncoproteins, and its dysregulation can contribute to tumor progression by abnormal activation of targeted oncogenes. Using data from the Cancer Genome Atlas, we tested the possible involvement of WSB1 in PC progression. A multi-dimensional scaling (MDS) model was applied to clarify the association of WSB1 expression with other key genes, such as c-myc, ERG, Enhancer of Zeste 1 and 2 (EHZ1 and EZH2), WNT10a, and WNT 10b. An increased WSB1 expression was associated with higher PC grades and with a worse prognosis. It was also positively related to EZH1, EZH2, WNT10a, and WNT10b. Moreover, MDS showed the central role of WSB1 in influencing the other target genes by its central location on the map. Our study is the first to show a link between WSB1 expression and other genes involved in PC progression, suggesting a novel role for WSB1 in PC progression. This network between WSB1 and EZH2 through WNT/β-catenin may have an important role in PC progression, as suggested by the association between high WSB1 expression and unfavorable prognosis in our analysis.
format Online
Article
Text
id pubmed-10454498
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104544982023-08-26 WSB1 Involvement in Prostate Cancer Progression Boldrini, Laura Bardi, Massimo Genes (Basel) Article Prostate cancer (PC) is polygenic disease involving many genes, and more importantly a host of gene–gene interactions, including transcriptional factors. The WSB1 gene is a transcriptional target of numerous oncoproteins, and its dysregulation can contribute to tumor progression by abnormal activation of targeted oncogenes. Using data from the Cancer Genome Atlas, we tested the possible involvement of WSB1 in PC progression. A multi-dimensional scaling (MDS) model was applied to clarify the association of WSB1 expression with other key genes, such as c-myc, ERG, Enhancer of Zeste 1 and 2 (EHZ1 and EZH2), WNT10a, and WNT 10b. An increased WSB1 expression was associated with higher PC grades and with a worse prognosis. It was also positively related to EZH1, EZH2, WNT10a, and WNT10b. Moreover, MDS showed the central role of WSB1 in influencing the other target genes by its central location on the map. Our study is the first to show a link between WSB1 expression and other genes involved in PC progression, suggesting a novel role for WSB1 in PC progression. This network between WSB1 and EZH2 through WNT/β-catenin may have an important role in PC progression, as suggested by the association between high WSB1 expression and unfavorable prognosis in our analysis. MDPI 2023-07-29 /pmc/articles/PMC10454498/ /pubmed/37628609 http://dx.doi.org/10.3390/genes14081558 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boldrini, Laura
Bardi, Massimo
WSB1 Involvement in Prostate Cancer Progression
title WSB1 Involvement in Prostate Cancer Progression
title_full WSB1 Involvement in Prostate Cancer Progression
title_fullStr WSB1 Involvement in Prostate Cancer Progression
title_full_unstemmed WSB1 Involvement in Prostate Cancer Progression
title_short WSB1 Involvement in Prostate Cancer Progression
title_sort wsb1 involvement in prostate cancer progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454498/
https://www.ncbi.nlm.nih.gov/pubmed/37628609
http://dx.doi.org/10.3390/genes14081558
work_keys_str_mv AT boldrinilaura wsb1involvementinprostatecancerprogression
AT bardimassimo wsb1involvementinprostatecancerprogression