Cargando…

Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility

Spermatogenesis is a very complex process with an intricate transcriptional regulation. The transition from the diploid to the haploid state requires the involvement of specialized genes in meiosis, among other specific functions for the formation of the spermatozoon. The transcription factor cAMP-r...

Descripción completa

Detalles Bibliográficos
Autores principales: Sánchez-Jasso, Diego Eduardo, López-Guzmán, Sergio Federico, Bermúdez-Cruz, Rosa Maria, Oviedo, Norma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454534/
https://www.ncbi.nlm.nih.gov/pubmed/37628737
http://dx.doi.org/10.3390/ijms241612558
_version_ 1785096216173871104
author Sánchez-Jasso, Diego Eduardo
López-Guzmán, Sergio Federico
Bermúdez-Cruz, Rosa Maria
Oviedo, Norma
author_facet Sánchez-Jasso, Diego Eduardo
López-Guzmán, Sergio Federico
Bermúdez-Cruz, Rosa Maria
Oviedo, Norma
author_sort Sánchez-Jasso, Diego Eduardo
collection PubMed
description Spermatogenesis is a very complex process with an intricate transcriptional regulation. The transition from the diploid to the haploid state requires the involvement of specialized genes in meiosis, among other specific functions for the formation of the spermatozoon. The transcription factor cAMP-response element modulator (CREM) is a key modulator that triggers the differentiation of the germ cell into the spermatozoon through the modification of gene expression. CREM has multiple repressor and activator isoforms whose expression is tissue-cell-type specific and tightly regulated by various factors at the transcriptional, post-transcriptional and post-translational level. The activator isoform CREMτ controls the expression of several relevant genes in post-meiotic stages of spermatogenesis. In addition, exposure to xenobiotics negatively affects CREMτ expression, which is linked to male infertility. On the other hand, antioxidants could have a positive effect on CREMτ expression and improve sperm parameters in idiopathically infertile men. Therefore, CREM expression could be used as a biomarker to detect and even counteract male infertility. This review examines the importance of CREM as a transcription factor for sperm production and its relevance in male fertility, infertility and the response to environmental xenobiotics that may affect CREMτ expression and the downstream regulation that alters male fertility. Also, some health disorders in which CREM expression is altered are discussed.
format Online
Article
Text
id pubmed-10454534
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104545342023-08-26 Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility Sánchez-Jasso, Diego Eduardo López-Guzmán, Sergio Federico Bermúdez-Cruz, Rosa Maria Oviedo, Norma Int J Mol Sci Review Spermatogenesis is a very complex process with an intricate transcriptional regulation. The transition from the diploid to the haploid state requires the involvement of specialized genes in meiosis, among other specific functions for the formation of the spermatozoon. The transcription factor cAMP-response element modulator (CREM) is a key modulator that triggers the differentiation of the germ cell into the spermatozoon through the modification of gene expression. CREM has multiple repressor and activator isoforms whose expression is tissue-cell-type specific and tightly regulated by various factors at the transcriptional, post-transcriptional and post-translational level. The activator isoform CREMτ controls the expression of several relevant genes in post-meiotic stages of spermatogenesis. In addition, exposure to xenobiotics negatively affects CREMτ expression, which is linked to male infertility. On the other hand, antioxidants could have a positive effect on CREMτ expression and improve sperm parameters in idiopathically infertile men. Therefore, CREM expression could be used as a biomarker to detect and even counteract male infertility. This review examines the importance of CREM as a transcription factor for sperm production and its relevance in male fertility, infertility and the response to environmental xenobiotics that may affect CREMτ expression and the downstream regulation that alters male fertility. Also, some health disorders in which CREM expression is altered are discussed. MDPI 2023-08-08 /pmc/articles/PMC10454534/ /pubmed/37628737 http://dx.doi.org/10.3390/ijms241612558 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sánchez-Jasso, Diego Eduardo
López-Guzmán, Sergio Federico
Bermúdez-Cruz, Rosa Maria
Oviedo, Norma
Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility
title Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility
title_full Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility
title_fullStr Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility
title_full_unstemmed Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility
title_short Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility
title_sort novel aspects of camp-response element modulator (crem) role in spermatogenesis and male fertility
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454534/
https://www.ncbi.nlm.nih.gov/pubmed/37628737
http://dx.doi.org/10.3390/ijms241612558
work_keys_str_mv AT sanchezjassodiegoeduardo novelaspectsofcampresponseelementmodulatorcremroleinspermatogenesisandmalefertility
AT lopezguzmansergiofederico novelaspectsofcampresponseelementmodulatorcremroleinspermatogenesisandmalefertility
AT bermudezcruzrosamaria novelaspectsofcampresponseelementmodulatorcremroleinspermatogenesisandmalefertility
AT oviedonorma novelaspectsofcampresponseelementmodulatorcremroleinspermatogenesisandmalefertility