A Novel Aniline Derivative from Peganum harmala L. Promoted Apoptosis via Activating PI3K/AKT/mTOR-Mediated Autophagy in Non-Small Cell Lung Cancer Cells

Non-small cell lung cancer (NSCLC) is a common clinical malignant tumor with limited therapeutic drugs. Leading by cytotoxicity against NSCLC cell lines (A549 and PC9), bioactivity-guided isolation of components from Peganum harmala seeds led to the isolation of pegaharoline A (PA). PA was elucidate...

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Detalles Bibliográficos
Autores principales: Wu, Zhongnan, Li, Wen, Tang, Qing, Huang, Laiqiang, Zhan, Zhaochun, Li, Yaolan, Wang, Guocai, Dai, Xiaoyong, Zhang, Yubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454575/
https://www.ncbi.nlm.nih.gov/pubmed/37628807
http://dx.doi.org/10.3390/ijms241612626

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