Cargando…

Examination of Factors Affecting Site-Directed RNA Editing by the MS2-ADAR1 Deaminase System

Adenosine deaminases acting on RNA (ADARs) have double-stranded RNA binding domains and a deaminase domain (DD). We used the MS2 system and specific guide RNAs to direct ADAR1-DD to target adenosines in the mRNA encoding-enhanced green fluorescence protein. Using this system in transfected HEK-293 c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Azad, Md Thoufic Anam, Qulsum, Umme, Tsukahara, Toshifumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454654/ https://www.ncbi.nlm.nih.gov/pubmed/37628635 http://dx.doi.org/10.3390/genes14081584

Ejemplares similares

Development of a Single Construct System for Site-Directed RNA Editing Using MS2-ADAR
por: Tohama, Tetsuto, et al.
Publicado: (2020)

Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes
por: Keegan, Liam P, et al.
Publicado: (2004)

Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2
por: Phelps, Kelly J., et al.
Publicado: (2015)

Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma
por: Tomaselli, Sara, et al.
Publicado: (2015)

Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity
por: Katrekar, Dhruva, et al.
Publicado: (2022)

C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code
por: Bhakta, Sonali, et al.
Publicado: (2022)

Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection
por: Doria, Margherita, et al.
Publicado: (2009)

Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans
por: Schneider, Marius F., et al.
Publicado: (2014)

Predicting sites of ADAR editing in double-stranded RNA
por: Eggington, Julie M., et al.
Publicado: (2011)

RNA editing of BFP, a point mutant of GFP, using artificial APOBEC1 deaminase to restore the genetic code
por: Bhakta, Sonali, et al.
Publicado: (2020)

A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma
por: Chan, Tim Hon Man, et al.
Publicado: (2014)

Applying Human ADAR1p110 and ADAR1p150 for Site-Directed RNA Editing—G/C Substitution Stabilizes GuideRNAs against Editing
por: Heep, Madeleine, et al.
Publicado: (2017)

The ADAR Family in Amphioxus: RNA Editing and Conserved Orthologous Site Predictions
por: Zawisza-Álvarez, Michał, et al.
Publicado: (2020)

Promoting RNA editing by ADAR attraction
por: Danan-Gotthold, Miri, et al.
Publicado: (2017)

ADAR RNA editing below the backbone
por: Keegan, Liam, et al.
Publicado: (2017)

Cleavage of dsRNAs hyper-edited by ADARs occurs at preferred editing sites
por: Scadden, A. D. J., et al.
Publicado: (2005)

RNA editing by the host ADAR system affects the molecular evolution of the Zika virus
por: Piontkivska, Helen, et al.
Publicado: (2017)

Adenosine Deaminase Acting on RNA (ADAR) Enzymes: A Journey from Weird to Wondrous
por: Keegan, Liam P., et al.
Publicado: (2023)

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses
por: Tang, Qiannan, et al.
Publicado: (2021)

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms
por: Kleinova, Renata, et al.
Publicado: (2023)

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
por: Gannon, Hugh S., et al.
Publicado: (2018)

The origin of the ADAR gene family and animal RNA editing
por: Grice, Laura F, et al.
Publicado: (2015)

RNA Editing, ADAR1, and the Innate Immune Response
por: Wang, Qingde, et al.
Publicado: (2017)

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
por: Walkley, Carl R., et al.
Publicado: (2017)

ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site
por: Doherty, Erin E, et al.
Publicado: (2022)

A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing
por: Costa Cruz, Pedro Henrique, et al.
Publicado: (2020)

Lessons from discovery of true ADAR RNA editing sites in a human cell line
por: Wang, Fang, et al.
Publicado: (2023)

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
por: Keegan, Liam P., et al.
Publicado: (2011)

ADAR1 Editing and its Role in Cancer
por: Xu, Li-Di, et al.
Publicado: (2018)

ADAR Editing in Viruses: An Evolutionary Force to Reckon with
por: Piontkivska, Helen, et al.
Publicado: (2021)

Modulation of ADAR1 editing activity by Z-RNA in vitro
por: Koeris, Michael, et al.
Publicado: (2005)

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression
por: Wang, Isabel X., et al.
Publicado: (2013)

Complex regulation of ADAR-mediated RNA-editing across tissues
por: Huntley, Melanie A., et al.
Publicado: (2016)

Novel Engineered Programmable Systems for ADAR-Mediated RNA Editing
por: Aquino-Jarquin, Guillermo
Publicado: (2020)

ADAR1-Mediated RNA Editing and Its Role in Cancer
por: Liu, Jizhe, et al.
Publicado: (2022)

RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing
por: Xing, Yanfang, et al.
Publicado: (2023)

Editing independent effects of ADARs on the miRNA/siRNA pathways
por: Heale, Bret S E, et al.
Publicado: (2009)

Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
por: Gannon, Hugh S., et al.
Publicado: (2022)

Adenosine Deaminase Acting on RNA-1 (ADAR1) Inhibits HIV-1 Replication in Human Alveolar Macrophages
por: Weiden, Michael D., et al.
Publicado: (2014)

SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates
por: Shanmugam, Raghuvaran, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6tan4jk4t15167katoa3a1ijbs