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Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications

Partial reversible inhibition of enzymes, also called hyperbolic inhibition, is an uncommon mechanism of reversible inhibition, resulting from a productive enzyme–inhibitor complex. This type of inhibition can involve competitive, mixed, non-competitive and uncompetitive inhibitors. While full rever...

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Detalles Bibliográficos
Autores principales: Masson, Patrick, Mukhametgalieva, Aliya R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454656/
https://www.ncbi.nlm.nih.gov/pubmed/37629158
http://dx.doi.org/10.3390/ijms241612973
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author Masson, Patrick
Mukhametgalieva, Aliya R.
author_facet Masson, Patrick
Mukhametgalieva, Aliya R.
author_sort Masson, Patrick
collection PubMed
description Partial reversible inhibition of enzymes, also called hyperbolic inhibition, is an uncommon mechanism of reversible inhibition, resulting from a productive enzyme–inhibitor complex. This type of inhibition can involve competitive, mixed, non-competitive and uncompetitive inhibitors. While full reversible inhibitors show linear plots for reciprocal enzyme initial velocity versus inhibitor concentration, partial inhibitors produce hyperbolic plots. Similarly, dose–response curves show residual fractional activity of enzymes at high doses. This article reviews the theory and methods of analysis and discusses the significance of this type of reversible enzyme inhibition in metabolic processes, and its implications in pharmacology and toxicology.
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spelling pubmed-104546562023-08-26 Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications Masson, Patrick Mukhametgalieva, Aliya R. Int J Mol Sci Review Partial reversible inhibition of enzymes, also called hyperbolic inhibition, is an uncommon mechanism of reversible inhibition, resulting from a productive enzyme–inhibitor complex. This type of inhibition can involve competitive, mixed, non-competitive and uncompetitive inhibitors. While full reversible inhibitors show linear plots for reciprocal enzyme initial velocity versus inhibitor concentration, partial inhibitors produce hyperbolic plots. Similarly, dose–response curves show residual fractional activity of enzymes at high doses. This article reviews the theory and methods of analysis and discusses the significance of this type of reversible enzyme inhibition in metabolic processes, and its implications in pharmacology and toxicology. MDPI 2023-08-19 /pmc/articles/PMC10454656/ /pubmed/37629158 http://dx.doi.org/10.3390/ijms241612973 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Masson, Patrick
Mukhametgalieva, Aliya R.
Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications
title Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications
title_full Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications
title_fullStr Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications
title_full_unstemmed Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications
title_short Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications
title_sort partial reversible inhibition of enzymes and its metabolic and pharmaco-toxicological implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454656/
https://www.ncbi.nlm.nih.gov/pubmed/37629158
http://dx.doi.org/10.3390/ijms241612973
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