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Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications
Partial reversible inhibition of enzymes, also called hyperbolic inhibition, is an uncommon mechanism of reversible inhibition, resulting from a productive enzyme–inhibitor complex. This type of inhibition can involve competitive, mixed, non-competitive and uncompetitive inhibitors. While full rever...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454656/ https://www.ncbi.nlm.nih.gov/pubmed/37629158 http://dx.doi.org/10.3390/ijms241612973 |
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author | Masson, Patrick Mukhametgalieva, Aliya R. |
author_facet | Masson, Patrick Mukhametgalieva, Aliya R. |
author_sort | Masson, Patrick |
collection | PubMed |
description | Partial reversible inhibition of enzymes, also called hyperbolic inhibition, is an uncommon mechanism of reversible inhibition, resulting from a productive enzyme–inhibitor complex. This type of inhibition can involve competitive, mixed, non-competitive and uncompetitive inhibitors. While full reversible inhibitors show linear plots for reciprocal enzyme initial velocity versus inhibitor concentration, partial inhibitors produce hyperbolic plots. Similarly, dose–response curves show residual fractional activity of enzymes at high doses. This article reviews the theory and methods of analysis and discusses the significance of this type of reversible enzyme inhibition in metabolic processes, and its implications in pharmacology and toxicology. |
format | Online Article Text |
id | pubmed-10454656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104546562023-08-26 Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications Masson, Patrick Mukhametgalieva, Aliya R. Int J Mol Sci Review Partial reversible inhibition of enzymes, also called hyperbolic inhibition, is an uncommon mechanism of reversible inhibition, resulting from a productive enzyme–inhibitor complex. This type of inhibition can involve competitive, mixed, non-competitive and uncompetitive inhibitors. While full reversible inhibitors show linear plots for reciprocal enzyme initial velocity versus inhibitor concentration, partial inhibitors produce hyperbolic plots. Similarly, dose–response curves show residual fractional activity of enzymes at high doses. This article reviews the theory and methods of analysis and discusses the significance of this type of reversible enzyme inhibition in metabolic processes, and its implications in pharmacology and toxicology. MDPI 2023-08-19 /pmc/articles/PMC10454656/ /pubmed/37629158 http://dx.doi.org/10.3390/ijms241612973 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Masson, Patrick Mukhametgalieva, Aliya R. Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications |
title | Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications |
title_full | Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications |
title_fullStr | Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications |
title_full_unstemmed | Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications |
title_short | Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications |
title_sort | partial reversible inhibition of enzymes and its metabolic and pharmaco-toxicological implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454656/ https://www.ncbi.nlm.nih.gov/pubmed/37629158 http://dx.doi.org/10.3390/ijms241612973 |
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