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Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis
Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years. With the continuous reporting of in-depth research on the pathological mechanisms of sepsis, various compounds have been developed to prevent and treat sepsis. Natural small-molecul...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454676/ https://www.ncbi.nlm.nih.gov/pubmed/37628912 http://dx.doi.org/10.3390/ijms241612732 |
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author | Su, Jingqian Zhou, Fen Wu, Shun Tong, Zhiyong |
author_facet | Su, Jingqian Zhou, Fen Wu, Shun Tong, Zhiyong |
author_sort | Su, Jingqian |
collection | PubMed |
description | Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years. With the continuous reporting of in-depth research on the pathological mechanisms of sepsis, various compounds have been developed to prevent and treat sepsis. Natural small-molecule compounds play vital roles in the prevention and treatment of sepsis; for example, compounds such as resveratrol, emodin, salidroside, ginsenoside, and others can modulate signaling through the NF-κB, STAT3, STAT1, PI3K, and other pathways to relieve the inflammatory response, immunosuppression, and organ failure caused by sepsis. Here, we discuss the functions and mechanisms of natural small-molecule compounds in preventing and treating sepsis. This review will lay the theoretical foundation for discovering new natural small-molecule compounds that can potentially prevent and treat sepsis. |
format | Online Article Text |
id | pubmed-10454676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104546762023-08-26 Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis Su, Jingqian Zhou, Fen Wu, Shun Tong, Zhiyong Int J Mol Sci Review Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years. With the continuous reporting of in-depth research on the pathological mechanisms of sepsis, various compounds have been developed to prevent and treat sepsis. Natural small-molecule compounds play vital roles in the prevention and treatment of sepsis; for example, compounds such as resveratrol, emodin, salidroside, ginsenoside, and others can modulate signaling through the NF-κB, STAT3, STAT1, PI3K, and other pathways to relieve the inflammatory response, immunosuppression, and organ failure caused by sepsis. Here, we discuss the functions and mechanisms of natural small-molecule compounds in preventing and treating sepsis. This review will lay the theoretical foundation for discovering new natural small-molecule compounds that can potentially prevent and treat sepsis. MDPI 2023-08-12 /pmc/articles/PMC10454676/ /pubmed/37628912 http://dx.doi.org/10.3390/ijms241612732 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Su, Jingqian Zhou, Fen Wu, Shun Tong, Zhiyong Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis |
title | Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis |
title_full | Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis |
title_fullStr | Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis |
title_full_unstemmed | Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis |
title_short | Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis |
title_sort | research progress on natural small-molecule compounds for the prevention and treatment of sepsis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454676/ https://www.ncbi.nlm.nih.gov/pubmed/37628912 http://dx.doi.org/10.3390/ijms241612732 |
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