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Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis

Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years. With the continuous reporting of in-depth research on the pathological mechanisms of sepsis, various compounds have been developed to prevent and treat sepsis. Natural small-molecul...

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Detalles Bibliográficos
Autores principales: Su, Jingqian, Zhou, Fen, Wu, Shun, Tong, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454676/
https://www.ncbi.nlm.nih.gov/pubmed/37628912
http://dx.doi.org/10.3390/ijms241612732
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author Su, Jingqian
Zhou, Fen
Wu, Shun
Tong, Zhiyong
author_facet Su, Jingqian
Zhou, Fen
Wu, Shun
Tong, Zhiyong
author_sort Su, Jingqian
collection PubMed
description Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years. With the continuous reporting of in-depth research on the pathological mechanisms of sepsis, various compounds have been developed to prevent and treat sepsis. Natural small-molecule compounds play vital roles in the prevention and treatment of sepsis; for example, compounds such as resveratrol, emodin, salidroside, ginsenoside, and others can modulate signaling through the NF-κB, STAT3, STAT1, PI3K, and other pathways to relieve the inflammatory response, immunosuppression, and organ failure caused by sepsis. Here, we discuss the functions and mechanisms of natural small-molecule compounds in preventing and treating sepsis. This review will lay the theoretical foundation for discovering new natural small-molecule compounds that can potentially prevent and treat sepsis.
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spelling pubmed-104546762023-08-26 Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis Su, Jingqian Zhou, Fen Wu, Shun Tong, Zhiyong Int J Mol Sci Review Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years. With the continuous reporting of in-depth research on the pathological mechanisms of sepsis, various compounds have been developed to prevent and treat sepsis. Natural small-molecule compounds play vital roles in the prevention and treatment of sepsis; for example, compounds such as resveratrol, emodin, salidroside, ginsenoside, and others can modulate signaling through the NF-κB, STAT3, STAT1, PI3K, and other pathways to relieve the inflammatory response, immunosuppression, and organ failure caused by sepsis. Here, we discuss the functions and mechanisms of natural small-molecule compounds in preventing and treating sepsis. This review will lay the theoretical foundation for discovering new natural small-molecule compounds that can potentially prevent and treat sepsis. MDPI 2023-08-12 /pmc/articles/PMC10454676/ /pubmed/37628912 http://dx.doi.org/10.3390/ijms241612732 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Su, Jingqian
Zhou, Fen
Wu, Shun
Tong, Zhiyong
Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis
title Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis
title_full Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis
title_fullStr Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis
title_full_unstemmed Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis
title_short Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis
title_sort research progress on natural small-molecule compounds for the prevention and treatment of sepsis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454676/
https://www.ncbi.nlm.nih.gov/pubmed/37628912
http://dx.doi.org/10.3390/ijms241612732
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