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Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis

Aging can change the ability to respond to various stimuli and physical conditions. A decreased immune response is a form of deterioration of function in older people, who then become more vulnerable when exposed to pathogens. Periodontitis is an inflammatory disease of the periodontal tissues that...

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Autores principales: Sumbayak, Ines Augustina, Masulili, Sri Lelyati C., Tadjoedin, Fatimah Maria, Sulijaya, Benso, Mutiara, Arrum, Khoirowati, Diana, Soeroso, Yuniarti, Bachtiar, Boy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454687/
https://www.ncbi.nlm.nih.gov/pubmed/37623272
http://dx.doi.org/10.3390/geriatrics8040079
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author Sumbayak, Ines Augustina
Masulili, Sri Lelyati C.
Tadjoedin, Fatimah Maria
Sulijaya, Benso
Mutiara, Arrum
Khoirowati, Diana
Soeroso, Yuniarti
Bachtiar, Boy M.
author_facet Sumbayak, Ines Augustina
Masulili, Sri Lelyati C.
Tadjoedin, Fatimah Maria
Sulijaya, Benso
Mutiara, Arrum
Khoirowati, Diana
Soeroso, Yuniarti
Bachtiar, Boy M.
author_sort Sumbayak, Ines Augustina
collection PubMed
description Aging can change the ability to respond to various stimuli and physical conditions. A decreased immune response is a form of deterioration of function in older people, who then become more vulnerable when exposed to pathogens. Periodontitis is an inflammatory disease of the periodontal tissues that often occurs in older people. This study aimed to clinically analyze the periodontal status and cytokine levels of IL-1β, TNF-α, and IL-10 in older people and adults with periodontitis. This clinical study examined 20 persons in a group of older people and 20 persons in a group of adults. The clinical measurements of periodontal status included the Simplified Oral Hygiene Index (OHI-S), Plaque Index (PlI), and Papilla Bleeding Index (PBI). The cytokine levels in gingival crevicular fluid (GCF) were quantified by using ELISA kits. The OHI-S, PlI, and PBI were found to be higher in the older group. The mean values of cytokines were higher in the older group than in adults, although no statistically significant differences were found. A strong correlation was found between the clinical measurements and the cytokine levels in the GCF. There was an increasing tendency of pro-inflammatory and anti-inflammatory cytokines in the older group compared to the adult group.
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spelling pubmed-104546872023-08-26 Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis Sumbayak, Ines Augustina Masulili, Sri Lelyati C. Tadjoedin, Fatimah Maria Sulijaya, Benso Mutiara, Arrum Khoirowati, Diana Soeroso, Yuniarti Bachtiar, Boy M. Geriatrics (Basel) Brief Report Aging can change the ability to respond to various stimuli and physical conditions. A decreased immune response is a form of deterioration of function in older people, who then become more vulnerable when exposed to pathogens. Periodontitis is an inflammatory disease of the periodontal tissues that often occurs in older people. This study aimed to clinically analyze the periodontal status and cytokine levels of IL-1β, TNF-α, and IL-10 in older people and adults with periodontitis. This clinical study examined 20 persons in a group of older people and 20 persons in a group of adults. The clinical measurements of periodontal status included the Simplified Oral Hygiene Index (OHI-S), Plaque Index (PlI), and Papilla Bleeding Index (PBI). The cytokine levels in gingival crevicular fluid (GCF) were quantified by using ELISA kits. The OHI-S, PlI, and PBI were found to be higher in the older group. The mean values of cytokines were higher in the older group than in adults, although no statistically significant differences were found. A strong correlation was found between the clinical measurements and the cytokine levels in the GCF. There was an increasing tendency of pro-inflammatory and anti-inflammatory cytokines in the older group compared to the adult group. MDPI 2023-08-10 /pmc/articles/PMC10454687/ /pubmed/37623272 http://dx.doi.org/10.3390/geriatrics8040079 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Sumbayak, Ines Augustina
Masulili, Sri Lelyati C.
Tadjoedin, Fatimah Maria
Sulijaya, Benso
Mutiara, Arrum
Khoirowati, Diana
Soeroso, Yuniarti
Bachtiar, Boy M.
Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis
title Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis
title_full Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis
title_fullStr Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis
title_full_unstemmed Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis
title_short Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis
title_sort changes in interleukin-1β, tumor necrosis factor-α, and interleukin-10 cytokines in older people with periodontitis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454687/
https://www.ncbi.nlm.nih.gov/pubmed/37623272
http://dx.doi.org/10.3390/geriatrics8040079
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