A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development

The lysosomal cation channel TMEM175 is a Parkinson’s disease-related protein and a promising drug target. Unlike whole-cell automated patch-clamp (APC), lysosomal patch-clamp (LPC) facilitates physiological conditions, but is not yet suitable for high-throughput screening (HTS) applications. Here,...

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Detalles Bibliográficos
Autores principales: Bazzone, Andre, Barthmes, Maria, George, Cecilia, Brinkwirth, Nina, Zerlotti, Rocco, Prinz, Valentin, Cole, Kim, Friis, Søren, Dickson, Alexander, Rice, Simon, Lim, Jongwon, Fern Toh, May, Mohammadi, Milad, Pau, Davide, Stone, David J., Renger, John J., Fertig, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454728/
https://www.ncbi.nlm.nih.gov/pubmed/37628970
http://dx.doi.org/10.3390/ijms241612788

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