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Analysis of Predicted Amino Acid Sequences of Diatom Microtubule Center Components
Diatoms synthesize species-specific exoskeletons inside cells under the control of the cytoskeleton and microtubule center. Previous studies have been conducted with the visualization of the microtubule center; however, its composition has not been studied and reliably established. In the present st...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454807/ https://www.ncbi.nlm.nih.gov/pubmed/37628962 http://dx.doi.org/10.3390/ijms241612781 |
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author | Petrova, Darya P. Morozov, Alexey A. Potapova, Nadezhda A. Bedoshvili, Yekaterina D. |
author_facet | Petrova, Darya P. Morozov, Alexey A. Potapova, Nadezhda A. Bedoshvili, Yekaterina D. |
author_sort | Petrova, Darya P. |
collection | PubMed |
description | Diatoms synthesize species-specific exoskeletons inside cells under the control of the cytoskeleton and microtubule center. Previous studies have been conducted with the visualization of the microtubule center; however, its composition has not been studied and reliably established. In the present study, several components of MTOC in diatoms, GCP (gamma complex proteins), Aurora A, and centrins have been identified. Analysis of the predicted amino acid sequences of these proteins revealed structural features typical for diatoms. We analyzed the conserved amino acids and the motives necessary for the functioning of proteins. Phylogenetic analysis of GCP showed that all major groups of diatoms are distributed over phylogenetic trees according to their systematic position. This work is a theoretical study; however, it allows drawing some conclusions about the functioning of the studied components and possible ways to regulate them. |
format | Online Article Text |
id | pubmed-10454807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104548072023-08-26 Analysis of Predicted Amino Acid Sequences of Diatom Microtubule Center Components Petrova, Darya P. Morozov, Alexey A. Potapova, Nadezhda A. Bedoshvili, Yekaterina D. Int J Mol Sci Article Diatoms synthesize species-specific exoskeletons inside cells under the control of the cytoskeleton and microtubule center. Previous studies have been conducted with the visualization of the microtubule center; however, its composition has not been studied and reliably established. In the present study, several components of MTOC in diatoms, GCP (gamma complex proteins), Aurora A, and centrins have been identified. Analysis of the predicted amino acid sequences of these proteins revealed structural features typical for diatoms. We analyzed the conserved amino acids and the motives necessary for the functioning of proteins. Phylogenetic analysis of GCP showed that all major groups of diatoms are distributed over phylogenetic trees according to their systematic position. This work is a theoretical study; however, it allows drawing some conclusions about the functioning of the studied components and possible ways to regulate them. MDPI 2023-08-14 /pmc/articles/PMC10454807/ /pubmed/37628962 http://dx.doi.org/10.3390/ijms241612781 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Petrova, Darya P. Morozov, Alexey A. Potapova, Nadezhda A. Bedoshvili, Yekaterina D. Analysis of Predicted Amino Acid Sequences of Diatom Microtubule Center Components |
title | Analysis of Predicted Amino Acid Sequences of Diatom Microtubule Center Components |
title_full | Analysis of Predicted Amino Acid Sequences of Diatom Microtubule Center Components |
title_fullStr | Analysis of Predicted Amino Acid Sequences of Diatom Microtubule Center Components |
title_full_unstemmed | Analysis of Predicted Amino Acid Sequences of Diatom Microtubule Center Components |
title_short | Analysis of Predicted Amino Acid Sequences of Diatom Microtubule Center Components |
title_sort | analysis of predicted amino acid sequences of diatom microtubule center components |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454807/ https://www.ncbi.nlm.nih.gov/pubmed/37628962 http://dx.doi.org/10.3390/ijms241612781 |
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