The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

In recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the p...

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Autores principales: Tregub, Pavel P., Ibrahimli, Irada, Averchuk, Anton S., Salmina, Alla B., Litvitskiy, Peter F., Manasova, Zaripat Sh., Popova, Inga A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454825/
https://www.ncbi.nlm.nih.gov/pubmed/37629078
http://dx.doi.org/10.3390/ijms241612899
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author Tregub, Pavel P.
Ibrahimli, Irada
Averchuk, Anton S.
Salmina, Alla B.
Litvitskiy, Peter F.
Manasova, Zaripat Sh.
Popova, Inga A.
author_facet Tregub, Pavel P.
Ibrahimli, Irada
Averchuk, Anton S.
Salmina, Alla B.
Litvitskiy, Peter F.
Manasova, Zaripat Sh.
Popova, Inga A.
author_sort Tregub, Pavel P.
collection PubMed
description In recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer’s disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood–brain barrier.
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spelling pubmed-104548252023-08-26 The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies Tregub, Pavel P. Ibrahimli, Irada Averchuk, Anton S. Salmina, Alla B. Litvitskiy, Peter F. Manasova, Zaripat Sh. Popova, Inga A. Int J Mol Sci Review In recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer’s disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood–brain barrier. MDPI 2023-08-17 /pmc/articles/PMC10454825/ /pubmed/37629078 http://dx.doi.org/10.3390/ijms241612899 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tregub, Pavel P.
Ibrahimli, Irada
Averchuk, Anton S.
Salmina, Alla B.
Litvitskiy, Peter F.
Manasova, Zaripat Sh.
Popova, Inga A.
The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies
title The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies
title_full The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies
title_fullStr The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies
title_full_unstemmed The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies
title_short The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies
title_sort role of micrornas in epigenetic regulation of signaling pathways in neurological pathologies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454825/
https://www.ncbi.nlm.nih.gov/pubmed/37629078
http://dx.doi.org/10.3390/ijms241612899
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