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Is it enough for COVID-19 screening test? Limitation of swab test and general characteristics of mild symptom patients

The most common method for SARS-CoV-2 testing is throat or nasal swabbing by real-time reverse transcription polymerase chain reaction (RT-PCR) assay. In South Korea, drive-through swab test is used for screening system and community treatment centers (CTCs), which admit and treat confirmed COVID-19...

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Autores principales: Choi, Sungwoo, Choi, Hyo Jeong, Kim, Ho Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454889/
https://www.ncbi.nlm.nih.gov/pubmed/34143699
http://dx.doi.org/10.1177/00368504211026152
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author Choi, Sungwoo
Choi, Hyo Jeong
Kim, Ho Jung
author_facet Choi, Sungwoo
Choi, Hyo Jeong
Kim, Ho Jung
author_sort Choi, Sungwoo
collection PubMed
description The most common method for SARS-CoV-2 testing is throat or nasal swabbing by real-time reverse transcription polymerase chain reaction (RT-PCR) assay. In South Korea, drive-through swab test is used for screening system and community treatment centers (CTCs), which admit and treat confirmed COVID-19 patients with mild symptoms, are being used. This retrospective study was conducted on patients admitted to a CTC on March 6, 2020. A total of 313 patients were admitted. The nasal and throat swabs were collected from the upper respiratory tract, and a sputum test was performed to obtain lower respiratory samples. The positive rate of the first set of test, sputum test was higher than that of the swab test (p = 0.011). In the second set of test, 1 week after the first ones, the rate of positive swab tests was relatively high (p = 0.026). In the first set of test, 66 of 152 (43.4%) patients showed 24-h consecutive negative swab test results, when the sputum test results were considered together, that number fell to 29 patients (19.1%) (p < 0.001). Also, in the second set of test, 63 of 164 (38.4%) patients met the discharge criteria only when the swab test was considered; that number fell to 30 (18.3%) when the sputum test results were also considered (p < 0.001). Using the swab test alone is insufficient for screening test and discharge decision. Patients who may have positive result in the sputum test can be missed.
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spelling pubmed-104548892023-08-26 Is it enough for COVID-19 screening test? Limitation of swab test and general characteristics of mild symptom patients Choi, Sungwoo Choi, Hyo Jeong Kim, Ho Jung Sci Prog Article The most common method for SARS-CoV-2 testing is throat or nasal swabbing by real-time reverse transcription polymerase chain reaction (RT-PCR) assay. In South Korea, drive-through swab test is used for screening system and community treatment centers (CTCs), which admit and treat confirmed COVID-19 patients with mild symptoms, are being used. This retrospective study was conducted on patients admitted to a CTC on March 6, 2020. A total of 313 patients were admitted. The nasal and throat swabs were collected from the upper respiratory tract, and a sputum test was performed to obtain lower respiratory samples. The positive rate of the first set of test, sputum test was higher than that of the swab test (p = 0.011). In the second set of test, 1 week after the first ones, the rate of positive swab tests was relatively high (p = 0.026). In the first set of test, 66 of 152 (43.4%) patients showed 24-h consecutive negative swab test results, when the sputum test results were considered together, that number fell to 29 patients (19.1%) (p < 0.001). Also, in the second set of test, 63 of 164 (38.4%) patients met the discharge criteria only when the swab test was considered; that number fell to 30 (18.3%) when the sputum test results were also considered (p < 0.001). Using the swab test alone is insufficient for screening test and discharge decision. Patients who may have positive result in the sputum test can be missed. SAGE Publications 2021-06-18 /pmc/articles/PMC10454889/ /pubmed/34143699 http://dx.doi.org/10.1177/00368504211026152 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Article
Choi, Sungwoo
Choi, Hyo Jeong
Kim, Ho Jung
Is it enough for COVID-19 screening test? Limitation of swab test and general characteristics of mild symptom patients
title Is it enough for COVID-19 screening test? Limitation of swab test and general characteristics of mild symptom patients
title_full Is it enough for COVID-19 screening test? Limitation of swab test and general characteristics of mild symptom patients
title_fullStr Is it enough for COVID-19 screening test? Limitation of swab test and general characteristics of mild symptom patients
title_full_unstemmed Is it enough for COVID-19 screening test? Limitation of swab test and general characteristics of mild symptom patients
title_short Is it enough for COVID-19 screening test? Limitation of swab test and general characteristics of mild symptom patients
title_sort is it enough for covid-19 screening test? limitation of swab test and general characteristics of mild symptom patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454889/
https://www.ncbi.nlm.nih.gov/pubmed/34143699
http://dx.doi.org/10.1177/00368504211026152
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