Piezo1 in Digestive System Function and Dysfunction

Piezo1, a non-selective cation channel directly activated by mechanical forces, is widely expressed in the digestive system and participates in biological functions physiologically and pathologically. In this review, we summarized the latest insights on Piezo1’s cellular effect across the entire dig...

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Autores principales: He, Jing, Xie, Xiaotian, Xiao, Zhuanglong, Qian, Wei, Zhang, Lei, Hou, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454946/
https://www.ncbi.nlm.nih.gov/pubmed/37629134
http://dx.doi.org/10.3390/ijms241612953
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author He, Jing
Xie, Xiaotian
Xiao, Zhuanglong
Qian, Wei
Zhang, Lei
Hou, Xiaohua
author_facet He, Jing
Xie, Xiaotian
Xiao, Zhuanglong
Qian, Wei
Zhang, Lei
Hou, Xiaohua
author_sort He, Jing
collection PubMed
description Piezo1, a non-selective cation channel directly activated by mechanical forces, is widely expressed in the digestive system and participates in biological functions physiologically and pathologically. In this review, we summarized the latest insights on Piezo1’s cellular effect across the entire digestive system, and discussed the role of Piezo1 in various aspects including ingestion and digestion, material metabolism, enteric nervous system, intestinal barrier, and inflammatory response within digestive system. The goal of this comprehensive review is to provide a solid foundation for future research about Piezo1 in digestive system physiologically and pathologically.
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spelling pubmed-104549462023-08-26 Piezo1 in Digestive System Function and Dysfunction He, Jing Xie, Xiaotian Xiao, Zhuanglong Qian, Wei Zhang, Lei Hou, Xiaohua Int J Mol Sci Review Piezo1, a non-selective cation channel directly activated by mechanical forces, is widely expressed in the digestive system and participates in biological functions physiologically and pathologically. In this review, we summarized the latest insights on Piezo1’s cellular effect across the entire digestive system, and discussed the role of Piezo1 in various aspects including ingestion and digestion, material metabolism, enteric nervous system, intestinal barrier, and inflammatory response within digestive system. The goal of this comprehensive review is to provide a solid foundation for future research about Piezo1 in digestive system physiologically and pathologically. MDPI 2023-08-19 /pmc/articles/PMC10454946/ /pubmed/37629134 http://dx.doi.org/10.3390/ijms241612953 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
He, Jing
Xie, Xiaotian
Xiao, Zhuanglong
Qian, Wei
Zhang, Lei
Hou, Xiaohua
Piezo1 in Digestive System Function and Dysfunction
title Piezo1 in Digestive System Function and Dysfunction
title_full Piezo1 in Digestive System Function and Dysfunction
title_fullStr Piezo1 in Digestive System Function and Dysfunction
title_full_unstemmed Piezo1 in Digestive System Function and Dysfunction
title_short Piezo1 in Digestive System Function and Dysfunction
title_sort piezo1 in digestive system function and dysfunction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10454946/
https://www.ncbi.nlm.nih.gov/pubmed/37629134
http://dx.doi.org/10.3390/ijms241612953
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AT xiexiaotian piezo1indigestivesystemfunctionanddysfunction
AT xiaozhuanglong piezo1indigestivesystemfunctionanddysfunction
AT qianwei piezo1indigestivesystemfunctionanddysfunction
AT zhanglei piezo1indigestivesystemfunctionanddysfunction
AT houxiaohua piezo1indigestivesystemfunctionanddysfunction

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