A review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation

DDIT4 is a mitochondrial and tumor-related protein involved in anti-tumor therapy resistance, proliferation, and invasion, etc. Its expression level increases under the stress such as chemotherapy, hypoxia, and DNA damage. A number of clinical studies have confirmed that DDIT4 can change the behavio...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Fadian, Gao, Feng, Zhang, Sheng, Lv, Xiaoting, Chen, Youting, Liu, Qicai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455034/
https://www.ncbi.nlm.nih.gov/pubmed/33729069
http://dx.doi.org/10.1177/0036850421997273
_version_ 1785096352416399360
author Ding, Fadian
Gao, Feng
Zhang, Sheng
Lv, Xiaoting
Chen, Youting
Liu, Qicai
author_facet Ding, Fadian
Gao, Feng
Zhang, Sheng
Lv, Xiaoting
Chen, Youting
Liu, Qicai
author_sort Ding, Fadian
collection PubMed
description DDIT4 is a mitochondrial and tumor-related protein involved in anti-tumor therapy resistance, proliferation, and invasion, etc. Its expression level increases under the stress such as chemotherapy, hypoxia, and DNA damage. A number of clinical studies have confirmed that DDIT4 can change the behavior of tumor cells and the prognosis of patients with cancer. However, the role of DDIT4 in promoting or suppressing cancer is still inconclusive. This article summarized the four characteristics of DDIT4 including a mitochondria-related protein, interactions with various protein molecules, immune and metabolic cell related proteins and participator in the oxygen sensing pathway, which may be related to the progress of cancer.
format Online
Article
Text
id pubmed-10455034
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-104550342023-08-26 A review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation Ding, Fadian Gao, Feng Zhang, Sheng Lv, Xiaoting Chen, Youting Liu, Qicai Sci Prog Article DDIT4 is a mitochondrial and tumor-related protein involved in anti-tumor therapy resistance, proliferation, and invasion, etc. Its expression level increases under the stress such as chemotherapy, hypoxia, and DNA damage. A number of clinical studies have confirmed that DDIT4 can change the behavior of tumor cells and the prognosis of patients with cancer. However, the role of DDIT4 in promoting or suppressing cancer is still inconclusive. This article summarized the four characteristics of DDIT4 including a mitochondria-related protein, interactions with various protein molecules, immune and metabolic cell related proteins and participator in the oxygen sensing pathway, which may be related to the progress of cancer. SAGE Publications 2021-03-17 /pmc/articles/PMC10455034/ /pubmed/33729069 http://dx.doi.org/10.1177/0036850421997273 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Article
Ding, Fadian
Gao, Feng
Zhang, Sheng
Lv, Xiaoting
Chen, Youting
Liu, Qicai
A review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation
title A review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation
title_full A review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation
title_fullStr A review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation
title_full_unstemmed A review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation
title_short A review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation
title_sort review of the mechanism of ddit4 serve as a mitochondrial related protein in tumor regulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455034/
https://www.ncbi.nlm.nih.gov/pubmed/33729069
http://dx.doi.org/10.1177/0036850421997273
work_keys_str_mv AT dingfadian areviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT gaofeng areviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT zhangsheng areviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT lvxiaoting areviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT chenyouting areviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT liuqicai areviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT dingfadian reviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT gaofeng reviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT zhangsheng reviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT lvxiaoting reviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT chenyouting reviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation
AT liuqicai reviewofthemechanismofddit4serveasamitochondrialrelatedproteinintumorregulation

Ejemplares similares