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Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study

Background: Delirium is highly prevalent among elderly hospitalized patients in various healthcare settings. This study aimed to assess the impact of delirium on short- and long-term health outcomes. Methods: A prospective cohort included medically ill patients (≥65 years) admitted to a tertiary hea...

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Autores principales: Al Huraizi, Aisha Ramadhan, Al-Maqbali, Juhaina Salim, Al Farsi, Rajaa Saleh, Al Zeedy, Khalfan, Al-Saadi, Taif, Al-Hamadani, Noof, Al Alawi, Abdullah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455146/
https://www.ncbi.nlm.nih.gov/pubmed/37629388
http://dx.doi.org/10.3390/jcm12165346
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author Al Huraizi, Aisha Ramadhan
Al-Maqbali, Juhaina Salim
Al Farsi, Rajaa Saleh
Al Zeedy, Khalfan
Al-Saadi, Taif
Al-Hamadani, Noof
Al Alawi, Abdullah M.
author_facet Al Huraizi, Aisha Ramadhan
Al-Maqbali, Juhaina Salim
Al Farsi, Rajaa Saleh
Al Zeedy, Khalfan
Al-Saadi, Taif
Al-Hamadani, Noof
Al Alawi, Abdullah M.
author_sort Al Huraizi, Aisha Ramadhan
collection PubMed
description Background: Delirium is highly prevalent among elderly hospitalized patients in various healthcare settings. This study aimed to assess the impact of delirium on short- and long-term health outcomes. Methods: A prospective cohort included medically ill patients (≥65 years) admitted to a tertiary healthcare facility. Delirium was screened using the 3-Minute Diagnostic confusion assessment method (3D-CAM). Results: During hospitalization, 53.8% (n = 153/284) had delirium. Patients with delirium had a longer length of hospital stay (LOS) (7 vs. 5 days; p < 0.01) compared to patients without delirium. Delirium caused a higher frequency of high-dependency unit (HDU) or intensive care unit (ICU) admission (p < 0.01) and an increased incidence of hospital-acquired complications, including infections (p = 0.03), pressure injuries (p = 0.01), and upper gastrointestinal bleeding (p < 0.01). Inpatient all-cause mortality was higher in patients with delirium than those without delirium (16.3% vs. 1.5%; p < 0.01). Patients with delirium had higher rates of 90-day all-cause mortality (25.4% vs. 8.4%; p < 0.01) and 1-year all-cause mortality (35.9% vs. 16%; p < 0.01) compared to patients without delirium. Patients with delirium exhibited shorter survival periods at 90 days and 1 year compared to patients without delirium with a hazard ratio (HR) = 3.41, 95% CI: 1.75–6.66, p < 0.01 and HR = 2.64, 95% CI: 1.59–4.37, p < 0.01, respectively. Conclusions: Delirium is associated with serious short-term and long-term clinical consequences. Early recognition, prevention, and targeted interventions addressing reversible risk factors are crucial. Further research is warranted to explore effective strategies for delirium management in general medical wards.
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spelling pubmed-104551462023-08-26 Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study Al Huraizi, Aisha Ramadhan Al-Maqbali, Juhaina Salim Al Farsi, Rajaa Saleh Al Zeedy, Khalfan Al-Saadi, Taif Al-Hamadani, Noof Al Alawi, Abdullah M. J Clin Med Article Background: Delirium is highly prevalent among elderly hospitalized patients in various healthcare settings. This study aimed to assess the impact of delirium on short- and long-term health outcomes. Methods: A prospective cohort included medically ill patients (≥65 years) admitted to a tertiary healthcare facility. Delirium was screened using the 3-Minute Diagnostic confusion assessment method (3D-CAM). Results: During hospitalization, 53.8% (n = 153/284) had delirium. Patients with delirium had a longer length of hospital stay (LOS) (7 vs. 5 days; p < 0.01) compared to patients without delirium. Delirium caused a higher frequency of high-dependency unit (HDU) or intensive care unit (ICU) admission (p < 0.01) and an increased incidence of hospital-acquired complications, including infections (p = 0.03), pressure injuries (p = 0.01), and upper gastrointestinal bleeding (p < 0.01). Inpatient all-cause mortality was higher in patients with delirium than those without delirium (16.3% vs. 1.5%; p < 0.01). Patients with delirium had higher rates of 90-day all-cause mortality (25.4% vs. 8.4%; p < 0.01) and 1-year all-cause mortality (35.9% vs. 16%; p < 0.01) compared to patients without delirium. Patients with delirium exhibited shorter survival periods at 90 days and 1 year compared to patients without delirium with a hazard ratio (HR) = 3.41, 95% CI: 1.75–6.66, p < 0.01 and HR = 2.64, 95% CI: 1.59–4.37, p < 0.01, respectively. Conclusions: Delirium is associated with serious short-term and long-term clinical consequences. Early recognition, prevention, and targeted interventions addressing reversible risk factors are crucial. Further research is warranted to explore effective strategies for delirium management in general medical wards. MDPI 2023-08-17 /pmc/articles/PMC10455146/ /pubmed/37629388 http://dx.doi.org/10.3390/jcm12165346 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al Huraizi, Aisha Ramadhan
Al-Maqbali, Juhaina Salim
Al Farsi, Rajaa Saleh
Al Zeedy, Khalfan
Al-Saadi, Taif
Al-Hamadani, Noof
Al Alawi, Abdullah M.
Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study
title Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study
title_full Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study
title_fullStr Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study
title_full_unstemmed Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study
title_short Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study
title_sort delirium and its association with short- and long-term health outcomes in medically admitted patients: a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455146/
https://www.ncbi.nlm.nih.gov/pubmed/37629388
http://dx.doi.org/10.3390/jcm12165346
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