Cargando…

In Silico Analysis, Anticonvulsant Activity, and Toxicity Evaluation of Schisandrin B in Zebrafish Larvae and Mice

The aim of this study is to evaluate the anticonvulsant potential of schisandrin B, a main ingredient of Schisandra chinensis extracts. Schisandrin B showed anticonvulsant activity in the zebrafish larva pentylenetetrazole acute seizure assay but did not alter seizure thresholds in the intravenous p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nieoczym, Dorota, Banono, Nancy Saana, Stępnik, Katarzyna, Kaczor, Agnieszka A., Szybkowski, Przemysław, Esguerra, Camila Vicencio, Kukula-Koch, Wirginia, Gawel, Kinga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455331/ https://www.ncbi.nlm.nih.gov/pubmed/37629132 http://dx.doi.org/10.3390/ijms241612949

Ejemplares similares

6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish
por: Gawel, Kinga, et al.
Publicado: (2021)

The Influence of Palmatine Isolated from Berberis sibirica Radix on Pentylenetetrazole-Induced Seizures in Zebrafish
por: Gawel, Kinga, et al.
Publicado: (2020)

Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours?
por: Banono, Nancy Saana, et al.
Publicado: (2020)

Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests
por: Nieoczym, Dorota, et al.
Publicado: (2019)

Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties—a review
por: Knap, Bartosz, et al.
Publicado: (2023)

Neuroprotective Properties of Oleanolic Acid—Computational-Driven Molecular Research Combined with In Vitro and In Vivo Experiments
por: Stępnik, Katarzyna, et al.
Publicado: (2023)

In Silico Studies on Triterpenoid Saponins Permeation through the Blood–Brain Barrier Combined with Postmortem Research on the Brain Tissues of Mice Affected by Astragaloside IV Administration
por: Stępnik, Katarzyna, et al.
Publicado: (2020)

Significance of Astragaloside IV from the Roots of Astragalus mongholicus as an Acetylcholinesterase Inhibitor—From the Computational and Biomimetic Analyses to the In Vitro and In Vivo Studies of Safety
por: Stępnik, Katarzyna, et al.
Publicado: (2023)

Molecular and Pharmacokinetic Aspects of the Acetylcholinesterase-Inhibitory Potential of the Oleanane-Type Triterpenes and Their Glycosides
por: Stępnik, Katarzyna, et al.
Publicado: (2023)

Assessment of the Anticonvulsant Potency of Ursolic Acid in Seizure Threshold Tests in Mice
por: Nieoczym, Dorota, et al.
Publicado: (2018)

The Evaluation of Pro-Cognitive and Antiamnestic Properties of Berberine and Magnoflorine Isolated from Barberry Species by Centrifugal Partition Chromatography (CPC), in Relation to QSAR Modelling
por: Kukula-Koch, Wirginia, et al.
Publicado: (2017)

Achillea Species as Sources of Active Phytochemicals for Dermatological and Cosmetic Applications
por: Strzępek-Gomółka, Marcelina, et al.
Publicado: (2021)

Isoquinoline Alkaloids from Coptis chinensis Franch: Focus on Coptisine as a Potential Therapeutic Candidate against Gastric Cancer Cells
por: Nakonieczna, Sylwia, et al.
Publicado: (2022)

Therapeutic Potential of 1,8-Dihydroanthraquinone Derivatives for Breast Cancer
por: Okon, Estera, et al.
Publicado: (2023)

Influence of sildenafil on the anticonvulsant action of selected antiepileptic drugs against pentylenetetrazole-induced clonic seizures in mice
por: Nieoczym, Dorota, et al.
Publicado: (2012)

The Elevation of LC-ESI-Q-TOF-MS Response in the Analysis of Isoquinoline Alkaloids from Some Papaveraceae and Berberidaceae Representatives
por: Kukula-Koch, Wirginia
Publicado: (2017)

Evaluation of 14 Organic Solvents and Carriers for Screening Applications in Zebrafish Embryos and Larvae
por: Maes, Jan, et al.
Publicado: (2012)

Evaluation of the Anticonvulsant Effect of Brilliant Blue G, a Selective P2X7 Receptor Antagonist, in the iv PTZ-, Maximal Electroshock-, and 6 Hz-Induced Seizure Tests in Mice
por: Nieoczym, Dorota, et al.
Publicado: (2017)

Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment
por: Pieróg, Mateusz, et al.
Publicado: (2023)

Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene
por: Gawel, Kinga, et al.
Publicado: (2019)

Achillea millefolium L. and Achillea biebersteinii Afan. Hydroglycolic Extracts–Bioactive Ingredients for Cosmetic Use
por: Gaweł-Bęben, Katarzyna, et al.
Publicado: (2020)

Characterization of Cistus × incanus L. and Cistus ladanifer L. Extracts as Potential Multifunctional Antioxidant Ingredients for Skin Protecting Cosmetics
por: Gaweł-Bęben, Katarzyna, et al.
Publicado: (2020)

Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients
por: Dziedzic, Marcin, et al.
Publicado: (2017)

Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties
por: Kukula-Koch, Wirginia, et al.
Publicado: (2021)

Application of hydrostatic CCC–TLC–HPLC–ESI-TOF-MS for the bioguided fractionation of anticholinesterase alkaloids from Argemone mexicana L. roots
por: Kukula-Koch, Wirginia, et al.
Publicado: (2015)

Black Tea Samples Origin Discrimination Using Analytical Investigations of Secondary Metabolites, Antiradical Scavenging Activity and Chemometric Approach
por: Koch, Wojciech, et al.
Publicado: (2018)

Correction: Koch, W., et al. Black Tea Samples Origin Discrimination Using Analytical Investigations of Secondary Metabolites, Antiradical Scavenging Activity and Chemometric Approach. Molecules 2018, 23, 513
por: Koch, Wojciech, et al.
Publicado: (2018)

Assessment of Cucurbita spp. Peel Extracts as Potential Sources of Active Substances for Skin Care and Dermatology
por: Gaweł-Bęben, Katarzyna, et al.
Publicado: (2022)

New Phenylglycinamide Derivatives with Hybrid Structure as Candidates for New Broad-Spectrum Anticonvulsants
por: Jakubiec, Marcin, et al.
Publicado: (2022)

Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies
por: Nieoczym, Dorota, et al.
Publicado: (2021)

The Potential Anticancer Activity of Phytoconstituents against Gastric Cancer—A Review on In Vitro, In Vivo, and Clinical Studies
por: Nakonieczna, Sylwia, et al.
Publicado: (2020)

Heterogeneous Cellular Response of Primary and Metastatic Human Gastric Adenocarcinoma Cell Lines to Magnoflorine and Its Additive Interaction with Docetaxel
por: Grabarska, Aneta, et al.
Publicado: (2023)

Identification of Mushroom and Murine Tyrosinase Inhibitors from Achillea biebersteinii Afan. Extract
por: Strzępek-Gomółka, Marcelina, et al.
Publicado: (2021)

Applications of Tea (Camellia sinensis) and Its Active Constituents in Cosmetics
por: Koch, Wojciech, et al.
Publicado: (2019)

Schisandrin B for the treatment of male infertility
por: Zou, Di‐Xin, et al.
Publicado: (2021)

N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug
por: Kamiński, Krzysztof, et al.
Publicado: (2019)

TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice
por: Doboszewska, Urszula, et al.
Publicado: (2023)

Zingiber officinale Rosc. in the Treatment of Metabolic Syndrome Disorders—A Review of In Vivo Studies
por: Gumbarewicz, Ewelina, et al.
Publicado: (2022)

Unravelling Novel Phytochemicals and Anticholinesterase Activity in Irish Cladonia portentosa
por: Nagar, Shipra, et al.
Publicado: (2023)

The Role of Extracting Solvents in the Recovery of Polyphenols from Green Tea and Its Antiradical Activity Supported by Principal Component Analysis
por: Koch, Wojciech, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_empnoinc29iuqvd3kh367qsnan