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Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes
This study investigates the clinical relevance and therapeutic implications of the OCT identification of intracoronary superficial calcified plates (SCPs) in acute coronary syndromes (ACSs). In 70 consecutive ACS patients (pts), we studied the three main underlying ACS mechanisms: plaque erosion (PE...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455434/ https://www.ncbi.nlm.nih.gov/pubmed/37629589 http://dx.doi.org/10.3390/life13081732 |
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author | Onea, Horea-Laurentiu Spinu, Mihail Homorodean, Calin Ober, Mihai Claudiu Olinic, Maria Lazar, Florin-Leontin Achim, Alexandru Tataru, Dan Alexandru Olinic, Dan Mircea |
author_facet | Onea, Horea-Laurentiu Spinu, Mihail Homorodean, Calin Ober, Mihai Claudiu Olinic, Maria Lazar, Florin-Leontin Achim, Alexandru Tataru, Dan Alexandru Olinic, Dan Mircea |
author_sort | Onea, Horea-Laurentiu |
collection | PubMed |
description | This study investigates the clinical relevance and therapeutic implications of the OCT identification of intracoronary superficial calcified plates (SCPs) in acute coronary syndromes (ACSs). In 70 consecutive ACS patients (pts), we studied the three main underlying ACS mechanisms: plaque erosion (PE), plaque rupture and eruptive calcified nodule (CN). The PE lesions, occurring on an intact fibrous cap overlying a heterogeneous substrate, were identified in 12/70 pts (17.1%). PE on superficial calcified plates (PE-SCP) represented 58.3% of the PE lesions (7/12 pts) and had a 10% overall incidence in the culprit lesions (7/70 pts). PE-SCP lesions occurred mostly on the left anterior descending artery, correlated with white thrombi (85.7%) and had a proximal intraplaque site (71.4%). PE-SCP lesions were treated conservatively, as nonsignificant lesions, in 4/7 pts. Our study emphasizes that the coronary calcium-related ACS risk is not only associated with the spotty calcifications or CN but also with the PE-SCP lesions. |
format | Online Article Text |
id | pubmed-10455434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104554342023-08-26 Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes Onea, Horea-Laurentiu Spinu, Mihail Homorodean, Calin Ober, Mihai Claudiu Olinic, Maria Lazar, Florin-Leontin Achim, Alexandru Tataru, Dan Alexandru Olinic, Dan Mircea Life (Basel) Article This study investigates the clinical relevance and therapeutic implications of the OCT identification of intracoronary superficial calcified plates (SCPs) in acute coronary syndromes (ACSs). In 70 consecutive ACS patients (pts), we studied the three main underlying ACS mechanisms: plaque erosion (PE), plaque rupture and eruptive calcified nodule (CN). The PE lesions, occurring on an intact fibrous cap overlying a heterogeneous substrate, were identified in 12/70 pts (17.1%). PE on superficial calcified plates (PE-SCP) represented 58.3% of the PE lesions (7/12 pts) and had a 10% overall incidence in the culprit lesions (7/70 pts). PE-SCP lesions occurred mostly on the left anterior descending artery, correlated with white thrombi (85.7%) and had a proximal intraplaque site (71.4%). PE-SCP lesions were treated conservatively, as nonsignificant lesions, in 4/7 pts. Our study emphasizes that the coronary calcium-related ACS risk is not only associated with the spotty calcifications or CN but also with the PE-SCP lesions. MDPI 2023-08-11 /pmc/articles/PMC10455434/ /pubmed/37629589 http://dx.doi.org/10.3390/life13081732 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Onea, Horea-Laurentiu Spinu, Mihail Homorodean, Calin Ober, Mihai Claudiu Olinic, Maria Lazar, Florin-Leontin Achim, Alexandru Tataru, Dan Alexandru Olinic, Dan Mircea Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes |
title | Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes |
title_full | Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes |
title_fullStr | Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes |
title_full_unstemmed | Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes |
title_short | Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes |
title_sort | superficial calcified plates associated to plaque erosions in acute coronary syndromes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455434/ https://www.ncbi.nlm.nih.gov/pubmed/37629589 http://dx.doi.org/10.3390/life13081732 |
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