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Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes

This study investigates the clinical relevance and therapeutic implications of the OCT identification of intracoronary superficial calcified plates (SCPs) in acute coronary syndromes (ACSs). In 70 consecutive ACS patients (pts), we studied the three main underlying ACS mechanisms: plaque erosion (PE...

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Autores principales: Onea, Horea-Laurentiu, Spinu, Mihail, Homorodean, Calin, Ober, Mihai Claudiu, Olinic, Maria, Lazar, Florin-Leontin, Achim, Alexandru, Tataru, Dan Alexandru, Olinic, Dan Mircea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455434/
https://www.ncbi.nlm.nih.gov/pubmed/37629589
http://dx.doi.org/10.3390/life13081732
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author Onea, Horea-Laurentiu
Spinu, Mihail
Homorodean, Calin
Ober, Mihai Claudiu
Olinic, Maria
Lazar, Florin-Leontin
Achim, Alexandru
Tataru, Dan Alexandru
Olinic, Dan Mircea
author_facet Onea, Horea-Laurentiu
Spinu, Mihail
Homorodean, Calin
Ober, Mihai Claudiu
Olinic, Maria
Lazar, Florin-Leontin
Achim, Alexandru
Tataru, Dan Alexandru
Olinic, Dan Mircea
author_sort Onea, Horea-Laurentiu
collection PubMed
description This study investigates the clinical relevance and therapeutic implications of the OCT identification of intracoronary superficial calcified plates (SCPs) in acute coronary syndromes (ACSs). In 70 consecutive ACS patients (pts), we studied the three main underlying ACS mechanisms: plaque erosion (PE), plaque rupture and eruptive calcified nodule (CN). The PE lesions, occurring on an intact fibrous cap overlying a heterogeneous substrate, were identified in 12/70 pts (17.1%). PE on superficial calcified plates (PE-SCP) represented 58.3% of the PE lesions (7/12 pts) and had a 10% overall incidence in the culprit lesions (7/70 pts). PE-SCP lesions occurred mostly on the left anterior descending artery, correlated with white thrombi (85.7%) and had a proximal intraplaque site (71.4%). PE-SCP lesions were treated conservatively, as nonsignificant lesions, in 4/7 pts. Our study emphasizes that the coronary calcium-related ACS risk is not only associated with the spotty calcifications or CN but also with the PE-SCP lesions.
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spelling pubmed-104554342023-08-26 Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes Onea, Horea-Laurentiu Spinu, Mihail Homorodean, Calin Ober, Mihai Claudiu Olinic, Maria Lazar, Florin-Leontin Achim, Alexandru Tataru, Dan Alexandru Olinic, Dan Mircea Life (Basel) Article This study investigates the clinical relevance and therapeutic implications of the OCT identification of intracoronary superficial calcified plates (SCPs) in acute coronary syndromes (ACSs). In 70 consecutive ACS patients (pts), we studied the three main underlying ACS mechanisms: plaque erosion (PE), plaque rupture and eruptive calcified nodule (CN). The PE lesions, occurring on an intact fibrous cap overlying a heterogeneous substrate, were identified in 12/70 pts (17.1%). PE on superficial calcified plates (PE-SCP) represented 58.3% of the PE lesions (7/12 pts) and had a 10% overall incidence in the culprit lesions (7/70 pts). PE-SCP lesions occurred mostly on the left anterior descending artery, correlated with white thrombi (85.7%) and had a proximal intraplaque site (71.4%). PE-SCP lesions were treated conservatively, as nonsignificant lesions, in 4/7 pts. Our study emphasizes that the coronary calcium-related ACS risk is not only associated with the spotty calcifications or CN but also with the PE-SCP lesions. MDPI 2023-08-11 /pmc/articles/PMC10455434/ /pubmed/37629589 http://dx.doi.org/10.3390/life13081732 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Onea, Horea-Laurentiu
Spinu, Mihail
Homorodean, Calin
Ober, Mihai Claudiu
Olinic, Maria
Lazar, Florin-Leontin
Achim, Alexandru
Tataru, Dan Alexandru
Olinic, Dan Mircea
Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes
title Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes
title_full Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes
title_fullStr Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes
title_full_unstemmed Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes
title_short Superficial Calcified Plates Associated to Plaque Erosions in Acute Coronary Syndromes
title_sort superficial calcified plates associated to plaque erosions in acute coronary syndromes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455434/
https://www.ncbi.nlm.nih.gov/pubmed/37629589
http://dx.doi.org/10.3390/life13081732
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