Cargando…

Aberrant HPO Axis Alterations and Autoimmune Abnormalities in PCOS Patients with DOR: A Retrospective Analysis

Background: There is a group of polycystic ovary syndrome (PCOS) patients in clinic who have diminished ovarian reserve (DOR) in combination. This study was designed to evaluate the differences in glucolipid metabolism, hypothalamic–pituitary–ovarian (HPO) axis-related parameters, and autoimmune ant...

Descripción completa

Detalles Bibliográficos
Autores principales: Geng, Xueying, He, Zhihong, Bao, Zhouzhou, Di, Wen, Gu, Zhuowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455465/
https://www.ncbi.nlm.nih.gov/pubmed/37629254
http://dx.doi.org/10.3390/jcm12165212
_version_ 1785096457734324224
author Geng, Xueying
He, Zhihong
Bao, Zhouzhou
Di, Wen
Gu, Zhuowei
author_facet Geng, Xueying
He, Zhihong
Bao, Zhouzhou
Di, Wen
Gu, Zhuowei
author_sort Geng, Xueying
collection PubMed
description Background: There is a group of polycystic ovary syndrome (PCOS) patients in clinic who have diminished ovarian reserve (DOR) in combination. This study was designed to evaluate the differences in glucolipid metabolism, hypothalamic–pituitary–ovarian (HPO) axis-related parameters, and autoimmune antibodies in PCOS patients with and without DOR. Methods: A total of 2307 PCOS patients, including 1757 patients with PCOS alone and 550 patients who have both PCOS and DOR, were enrolled in this retrospective study. Parameters of glucolipid metabolism, HPO axis-related parameters, and autoimmune antibodies were measured and analyzed. Results: The prevalence of DOR among all patients with PCOS was 23.84%. Many HPO axis-related parameters, such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and prolactin (PRL) were significantly different in PCOS with DOR compared with PCOS without DOR. The FSH levels were positively correlated with LH, testosterone (T), and androstenedione (AD) levels, but had no association with glucolipid metabolism after adjusting for body mass index (BMI). Moreover, anti-ovarian antibody (AOAb) and anti-21-OH antibody (21-OHAb) levels were significantly elevated in PCOS patients with DOR. Conclusions: PCOS patients with DOR showed more chaotic HPO axis hormone levels and elevated autoimmune antibodies, suggesting that autoimmune factors may be the cause of DOR in women with PCOS.
format Online
Article
Text
id pubmed-10455465
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104554652023-08-26 Aberrant HPO Axis Alterations and Autoimmune Abnormalities in PCOS Patients with DOR: A Retrospective Analysis Geng, Xueying He, Zhihong Bao, Zhouzhou Di, Wen Gu, Zhuowei J Clin Med Article Background: There is a group of polycystic ovary syndrome (PCOS) patients in clinic who have diminished ovarian reserve (DOR) in combination. This study was designed to evaluate the differences in glucolipid metabolism, hypothalamic–pituitary–ovarian (HPO) axis-related parameters, and autoimmune antibodies in PCOS patients with and without DOR. Methods: A total of 2307 PCOS patients, including 1757 patients with PCOS alone and 550 patients who have both PCOS and DOR, were enrolled in this retrospective study. Parameters of glucolipid metabolism, HPO axis-related parameters, and autoimmune antibodies were measured and analyzed. Results: The prevalence of DOR among all patients with PCOS was 23.84%. Many HPO axis-related parameters, such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and prolactin (PRL) were significantly different in PCOS with DOR compared with PCOS without DOR. The FSH levels were positively correlated with LH, testosterone (T), and androstenedione (AD) levels, but had no association with glucolipid metabolism after adjusting for body mass index (BMI). Moreover, anti-ovarian antibody (AOAb) and anti-21-OH antibody (21-OHAb) levels were significantly elevated in PCOS patients with DOR. Conclusions: PCOS patients with DOR showed more chaotic HPO axis hormone levels and elevated autoimmune antibodies, suggesting that autoimmune factors may be the cause of DOR in women with PCOS. MDPI 2023-08-10 /pmc/articles/PMC10455465/ /pubmed/37629254 http://dx.doi.org/10.3390/jcm12165212 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Geng, Xueying
He, Zhihong
Bao, Zhouzhou
Di, Wen
Gu, Zhuowei
Aberrant HPO Axis Alterations and Autoimmune Abnormalities in PCOS Patients with DOR: A Retrospective Analysis
title Aberrant HPO Axis Alterations and Autoimmune Abnormalities in PCOS Patients with DOR: A Retrospective Analysis
title_full Aberrant HPO Axis Alterations and Autoimmune Abnormalities in PCOS Patients with DOR: A Retrospective Analysis
title_fullStr Aberrant HPO Axis Alterations and Autoimmune Abnormalities in PCOS Patients with DOR: A Retrospective Analysis
title_full_unstemmed Aberrant HPO Axis Alterations and Autoimmune Abnormalities in PCOS Patients with DOR: A Retrospective Analysis
title_short Aberrant HPO Axis Alterations and Autoimmune Abnormalities in PCOS Patients with DOR: A Retrospective Analysis
title_sort aberrant hpo axis alterations and autoimmune abnormalities in pcos patients with dor: a retrospective analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455465/
https://www.ncbi.nlm.nih.gov/pubmed/37629254
http://dx.doi.org/10.3390/jcm12165212
work_keys_str_mv AT gengxueying aberranthpoaxisalterationsandautoimmuneabnormalitiesinpcospatientswithdoraretrospectiveanalysis
AT hezhihong aberranthpoaxisalterationsandautoimmuneabnormalitiesinpcospatientswithdoraretrospectiveanalysis
AT baozhouzhou aberranthpoaxisalterationsandautoimmuneabnormalitiesinpcospatientswithdoraretrospectiveanalysis
AT diwen aberranthpoaxisalterationsandautoimmuneabnormalitiesinpcospatientswithdoraretrospectiveanalysis
AT guzhuowei aberranthpoaxisalterationsandautoimmuneabnormalitiesinpcospatientswithdoraretrospectiveanalysis