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Red Cell Distribution Width as a Prognostic Indicator in Acute Medical Admissions

The red cell distribution width (RDW) is the coefficient of variation of the mean corpuscular volume (MCV). We sought to evaluate RDW as a predictor of outcomes following acute medical admission. We studied 10 years of acute medical admissions (2002–2011) with subsequent follow-up to 2021. RDW was c...

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Autores principales: Conway, Richard, Byrne, Declan, O’Riordan, Deirdre, Silke, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455471/
https://www.ncbi.nlm.nih.gov/pubmed/37629466
http://dx.doi.org/10.3390/jcm12165424
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author Conway, Richard
Byrne, Declan
O’Riordan, Deirdre
Silke, Bernard
author_facet Conway, Richard
Byrne, Declan
O’Riordan, Deirdre
Silke, Bernard
author_sort Conway, Richard
collection PubMed
description The red cell distribution width (RDW) is the coefficient of variation of the mean corpuscular volume (MCV). We sought to evaluate RDW as a predictor of outcomes following acute medical admission. We studied 10 years of acute medical admissions (2002–2011) with subsequent follow-up to 2021. RDW was converted to a categorical variable, Q1 < 12.9 fl, Q2–Q4 ≥ 12.9 and <15.7 fL and Q5 ≥ 15.7 fL. The predictive value of RDW for 30-day in-hospital and long-term mortality was evaluated with logistic and Cox regression modelling. Adjusted odds ratios (aORs) were calculated and loss of life years estimated. There were 62,184 admissions in 35,140 patients. The 30-day in-hospital mortality (n = 3646) occurred in 5.9% of admissions. An additional 15,086 (42.9%) deaths occurred by December 2021. Admission RDW independently predicted 30-day in-hospital mortality aOR 1.93 (95%CI 1.79, 2.07). Admission RDW independently predicted long-term mortality aOR 1.04 (95%CI 1.02, 1.05). Median survival post-admission was 189 months. For those with admission RDW in Q5, observed survival half-life was 133 months—this represents a shortfall of 5.7 life years (33.9%). In conclusion, admission RDW independently predicts 30-day in-hospital and long-term mortality.
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spelling pubmed-104554712023-08-26 Red Cell Distribution Width as a Prognostic Indicator in Acute Medical Admissions Conway, Richard Byrne, Declan O’Riordan, Deirdre Silke, Bernard J Clin Med Article The red cell distribution width (RDW) is the coefficient of variation of the mean corpuscular volume (MCV). We sought to evaluate RDW as a predictor of outcomes following acute medical admission. We studied 10 years of acute medical admissions (2002–2011) with subsequent follow-up to 2021. RDW was converted to a categorical variable, Q1 < 12.9 fl, Q2–Q4 ≥ 12.9 and <15.7 fL and Q5 ≥ 15.7 fL. The predictive value of RDW for 30-day in-hospital and long-term mortality was evaluated with logistic and Cox regression modelling. Adjusted odds ratios (aORs) were calculated and loss of life years estimated. There were 62,184 admissions in 35,140 patients. The 30-day in-hospital mortality (n = 3646) occurred in 5.9% of admissions. An additional 15,086 (42.9%) deaths occurred by December 2021. Admission RDW independently predicted 30-day in-hospital mortality aOR 1.93 (95%CI 1.79, 2.07). Admission RDW independently predicted long-term mortality aOR 1.04 (95%CI 1.02, 1.05). Median survival post-admission was 189 months. For those with admission RDW in Q5, observed survival half-life was 133 months—this represents a shortfall of 5.7 life years (33.9%). In conclusion, admission RDW independently predicts 30-day in-hospital and long-term mortality. MDPI 2023-08-21 /pmc/articles/PMC10455471/ /pubmed/37629466 http://dx.doi.org/10.3390/jcm12165424 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Conway, Richard
Byrne, Declan
O’Riordan, Deirdre
Silke, Bernard
Red Cell Distribution Width as a Prognostic Indicator in Acute Medical Admissions
title Red Cell Distribution Width as a Prognostic Indicator in Acute Medical Admissions
title_full Red Cell Distribution Width as a Prognostic Indicator in Acute Medical Admissions
title_fullStr Red Cell Distribution Width as a Prognostic Indicator in Acute Medical Admissions
title_full_unstemmed Red Cell Distribution Width as a Prognostic Indicator in Acute Medical Admissions
title_short Red Cell Distribution Width as a Prognostic Indicator in Acute Medical Admissions
title_sort red cell distribution width as a prognostic indicator in acute medical admissions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455471/
https://www.ncbi.nlm.nih.gov/pubmed/37629466
http://dx.doi.org/10.3390/jcm12165424
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