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Lung Transplantation Outcomes in Recipients Aged 70 Years or Older and the Impact of Center Volume

Objective: To evaluate trends and outcomes of lung transplants (LTx) in recipients ≥ 70 years. Methods: We performed a retrospective analysis of the UNOS database identifying all patients undergoing LTx (May 2005–December 2022). Baseline characteristics and postoperative outcomes were compared by ag...

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Autores principales: Iyanna, Nidhi, Chan, Ernest G., Ryan, John P., Furukawa, Masashi, Coster, Jenalee N., Hage, Chadi A., Sanchez, Pablo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455483/
https://www.ncbi.nlm.nih.gov/pubmed/37629414
http://dx.doi.org/10.3390/jcm12165372
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author Iyanna, Nidhi
Chan, Ernest G.
Ryan, John P.
Furukawa, Masashi
Coster, Jenalee N.
Hage, Chadi A.
Sanchez, Pablo G.
author_facet Iyanna, Nidhi
Chan, Ernest G.
Ryan, John P.
Furukawa, Masashi
Coster, Jenalee N.
Hage, Chadi A.
Sanchez, Pablo G.
author_sort Iyanna, Nidhi
collection PubMed
description Objective: To evaluate trends and outcomes of lung transplants (LTx) in recipients ≥ 70 years. Methods: We performed a retrospective analysis of the UNOS database identifying all patients undergoing LTx (May 2005–December 2022). Baseline characteristics and postoperative outcomes were compared by age (<70 years, ≥70 years) and center volume. Kaplan–Meier analyses were performed with pairwise comparisons between subgroups. Results: 34,957 patients underwent LTx, of which 3236 (9.3%) were ≥70 years. The rate of LTx in recipients ≥ 70 has increased over time, particularly in low-volume centers (LVCs); consequently, high-volume centers (HVCs) and LVCs perform similar rates of LTx for recipients ≥ 70. Recipients ≥ 70 had higher rates of receiving from donor after circulatory death lungs and of extended donor criteria. Recipients ≥ 70 were more likely to die of cardiovascular diseases or malignancy, while recipients < 70 of chronic primary graft failure. Survival time was shorter for recipients ≥ 70 compared to recipients < 70 old (hazard ratio (HR): 1.36, 95% confidence interval (CI): 1.28–1.44, p < 0.001). HVCs were associated with a survival advantage in recipients < 70 (HR: 0.91, 95% CI: 0.88–0.94, p < 0.001); however, in recipients ≥ 70, survival was similar between HVCs and LVCs (HR: 1.11, 95% CI: 0.99–1.25, p < 0.08). HVCs were more likely to perform a bilateral LTx (BLT) for obstructive lung diseases compared to LVCs, but there was no difference in BLT and single LTx likelihood for restrictive lung diseases. Conclusions: Careful consideration is needed for recipient ≥ 70 selection, donor assessment, and post-transplant care to improve outcomes. Further research should explore strategies that advance perioperative care in centers with low long-term survival for recipients ≥ 70.
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spelling pubmed-104554832023-08-26 Lung Transplantation Outcomes in Recipients Aged 70 Years or Older and the Impact of Center Volume Iyanna, Nidhi Chan, Ernest G. Ryan, John P. Furukawa, Masashi Coster, Jenalee N. Hage, Chadi A. Sanchez, Pablo G. J Clin Med Article Objective: To evaluate trends and outcomes of lung transplants (LTx) in recipients ≥ 70 years. Methods: We performed a retrospective analysis of the UNOS database identifying all patients undergoing LTx (May 2005–December 2022). Baseline characteristics and postoperative outcomes were compared by age (<70 years, ≥70 years) and center volume. Kaplan–Meier analyses were performed with pairwise comparisons between subgroups. Results: 34,957 patients underwent LTx, of which 3236 (9.3%) were ≥70 years. The rate of LTx in recipients ≥ 70 has increased over time, particularly in low-volume centers (LVCs); consequently, high-volume centers (HVCs) and LVCs perform similar rates of LTx for recipients ≥ 70. Recipients ≥ 70 had higher rates of receiving from donor after circulatory death lungs and of extended donor criteria. Recipients ≥ 70 were more likely to die of cardiovascular diseases or malignancy, while recipients < 70 of chronic primary graft failure. Survival time was shorter for recipients ≥ 70 compared to recipients < 70 old (hazard ratio (HR): 1.36, 95% confidence interval (CI): 1.28–1.44, p < 0.001). HVCs were associated with a survival advantage in recipients < 70 (HR: 0.91, 95% CI: 0.88–0.94, p < 0.001); however, in recipients ≥ 70, survival was similar between HVCs and LVCs (HR: 1.11, 95% CI: 0.99–1.25, p < 0.08). HVCs were more likely to perform a bilateral LTx (BLT) for obstructive lung diseases compared to LVCs, but there was no difference in BLT and single LTx likelihood for restrictive lung diseases. Conclusions: Careful consideration is needed for recipient ≥ 70 selection, donor assessment, and post-transplant care to improve outcomes. Further research should explore strategies that advance perioperative care in centers with low long-term survival for recipients ≥ 70. MDPI 2023-08-18 /pmc/articles/PMC10455483/ /pubmed/37629414 http://dx.doi.org/10.3390/jcm12165372 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iyanna, Nidhi
Chan, Ernest G.
Ryan, John P.
Furukawa, Masashi
Coster, Jenalee N.
Hage, Chadi A.
Sanchez, Pablo G.
Lung Transplantation Outcomes in Recipients Aged 70 Years or Older and the Impact of Center Volume
title Lung Transplantation Outcomes in Recipients Aged 70 Years or Older and the Impact of Center Volume
title_full Lung Transplantation Outcomes in Recipients Aged 70 Years or Older and the Impact of Center Volume
title_fullStr Lung Transplantation Outcomes in Recipients Aged 70 Years or Older and the Impact of Center Volume
title_full_unstemmed Lung Transplantation Outcomes in Recipients Aged 70 Years or Older and the Impact of Center Volume
title_short Lung Transplantation Outcomes in Recipients Aged 70 Years or Older and the Impact of Center Volume
title_sort lung transplantation outcomes in recipients aged 70 years or older and the impact of center volume
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455483/
https://www.ncbi.nlm.nih.gov/pubmed/37629414
http://dx.doi.org/10.3390/jcm12165372
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